scholarly journals Cullin 4A (CUL4A), a direct target of miR-9 and miR-137, promotes gastric cancer proliferation and invasion by regulating the Hippo signaling pathway

Oncotarget ◽  
2016 ◽  
Vol 7 (9) ◽  
pp. 10037-10050 ◽  
Author(s):  
Jun Deng ◽  
Wan Lei ◽  
Xiaojun Xiang ◽  
Ling Zhang ◽  
Jun Lei ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Signaling Pathway ◽  
Hippo Signaling ◽  
Cancer Proliferation ◽  
Hippo Signaling Pathway ◽  
Cullin 4A ◽  
Direct Target ◽  
Proliferation And Invasion

scholarly journals MST4 kinase suppresses gastric tumorigenesis by limiting YAP activation via a non-canonical pathway

2020 ◽  
Vol 217 (6) ◽  
Author(s):  
Liwei An ◽  
Pingping Nie ◽  
Min Chen ◽  
Yang Tang ◽  
Hui Zhang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Signaling Pathway ◽  
Poor Prognosis ◽  
Human Gastric Cancer ◽  
Hippo Signaling ◽  
Wild Type ◽  
Hippo Signaling Pathway ◽  
Phosphorylation Level ◽  
Signaling Axis ◽  
Importin Α

Hyperactivation of YAP has been commonly associated with tumorigenesis, and emerging evidence hints at multilayered Hippo-independent regulations of YAP. In this study, we identified a new MST4–YAP axis, which acts as a noncanonical Hippo signaling pathway that limits stress-induced YAP activation. MST4 kinase directly phosphorylated YAP at Thr83 to block its binding with importin α, therefore leading to YAP cytoplasmic retention and inactivation. Due to a consequential interplay between MST4-mediated YAP phospho-Thr83 signaling and the classical YAP phospho-Ser127 signaling, the phosphorylation level of YAP at Thr83 was correlated to that at Ser127. Mutation of T83E mimicking MST4-mediated alternative signaling restrained the activity of both wild-type YAP and its S127A mutant mimicking loss of classical Hippo signal. Depletion of MST4 in mice promoted gastric tumorigenesis with diminished Thr83 phosphorylation and hyperactivation of YAP. Moreover, loss of MST4–YAP signaling was associated with poor prognosis of human gastric cancer. Collectively, our study uncovered a noncanonical MST4–YAP signaling axis essential for suppressing gastric tumorigenesis.

MiR-93-5p promotes gastric cancer-cell progression via inactivation of the Hippo signaling pathway

Gene ◽  
2018 ◽  
Vol 641 ◽  
pp. 240-247 ◽  
Author(s):  
Li Li ◽  
Jianguo Zhao ◽  
Shanshan Huang ◽  
Yi Wang ◽  
Lingling Zhu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Signaling Pathway ◽  
Cancer Cell ◽  
Gastric Cancer Cell ◽  
Hippo Signaling ◽  
Hippo Signaling Pathway ◽  
Cell Progression

scholarly journals Effects of the Hippo Signaling Pathway in Human Gastric Cancer

2013 ◽  
Vol 14 (9) ◽  
pp. 5199-5205 ◽  
Author(s):  
Guang-Xi Zhou ◽  
Xiao-Yu Li ◽  
Qi Zhang ◽  
Kun Zhao ◽  
Cui-Ping Zhang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Signaling Pathway ◽  
Human Gastric Cancer ◽  
Hippo Signaling ◽  
Hippo Signaling Pathway

scholarly journals SRPX2 Promotes Cell Proliferation and Invasion in Osteosarcoma Through Regulating Hippo Signaling Pathway

2020 ◽  
Vol Volume 13 ◽  
pp. 1737-1749 ◽  
Author(s):  
Zhiqiang Wu ◽  
Chunmeng Wang ◽  
Yong Chen ◽  
Zhengwang Sun ◽  
Wangjun Yan
Keyword(s):  
Cell Proliferation ◽  
Signaling Pathway ◽  
Hippo Signaling ◽  
Hippo Signaling Pathway ◽  
Proliferation And Invasion

scholarly journals Potential Role of Hippo-Signaling Pathway in Gastric Cancer

OALib ◽  
2016 ◽  
Vol 03 (03) ◽  
pp. 1-7
Author(s):  
Noman Ali ◽  
Muhammad Asim ◽  
Raheel Asghar ◽  
Awais Amin ◽  
Muhammad Saif Ur Rahman
Keyword(s):  
Gastric Cancer ◽  
Signaling Pathway ◽  
Potential Role ◽  
Hippo Signaling ◽  
Hippo Signaling Pathway
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