scholarly journals Multipolar mitosis and aneuploidy after chrysotile treatment: a consequence of abscission failure and cytokinesis regression

Oncotarget ◽  
2016 ◽  
Vol 7 (8) ◽  
pp. 8979-8992 ◽  
Author(s):  
Beatriz Araujo Cortez ◽  
Paula Rezende Teixeira ◽  
Sambra Redick ◽  
Stephen Doxsey ◽  
Glaucia Maria Machado-Santelli
Keyword(s):  
Multipolar Mitosis

Inhibition of kinesin motor protein KIFC1 by AZ82 induces multipolar mitosis and apoptosis in prostate cancer cell

Gene ◽  
2020 ◽  
Vol 760 ◽  
pp. 144989
Author(s):  
Anzana Parvin ◽  
Shuang-Li Hao ◽  
Fu-Qing Tan ◽  
Wan-Xi Yang
Keyword(s):  
Prostate Cancer ◽  
Cancer Cell ◽  
Prostate Cancer Cell ◽  
Motor Protein ◽  
Kinesin Motor ◽  
Multipolar Mitosis

Kolavenic acid analog restores growth in HSET-overproducing fission yeast cells and multipolar mitosis in MDA-MB-231 human cells

2020 ◽  
Vol 28 (1) ◽  
pp. 115154
Author(s):  
Naoaki Kurisawa ◽  
Masashi Yukawa ◽  
Hiroyuki Koshino ◽  
Takumu Onodera ◽  
Takashi Toda ◽  
...  
Keyword(s):  
Fission Yeast ◽  
Human Cells ◽  
Yeast Cells ◽  
Multipolar Mitosis ◽  
Acid Analog

1,2:3,4-Diepoxybutane Induces Multipolar Mitosis in Cultured Human Lymphocytes

2016 ◽  
Vol 148 (2-3) ◽  
pp. 179-184 ◽  
Author(s):  
Reyna Lucía Barajas Torres ◽  
Martín Daniel Domínguez Cruz ◽  
César Borjas Gutiérrez ◽  
María de Lourdes Ramírez Dueñas ◽  
María Teresa Magaña Torres ◽  
...  
Keyword(s):  
Fanconi Anemia ◽  
Human Lymphocytes ◽  
Positive Control ◽  
Sister Chromatid Exchanges ◽  
Styrene Butadiene Rubber ◽  
Butadiene Rubber ◽  
Inherited Disease ◽  
Multipolar Mitosis ◽  
Lymphocyte Cultures ◽  
Chromosomal Breaks

1,3-Butadiene, a colorless gas regularly used in the production of plastics, thermoplastic resins, and styrene-butadiene rubber, poses an increased leukemia mortality risk to workers in this field. 1,3-Butadiene is also produced by incomplete combustion of motor fuels or by tobacco smoking. It is absorbed principally through the respiratory system and metabolized by several enzymes rendering 1,2:3,4-diepoxybutane (DEB), which has the highest genotoxic potency of all metabolites of 1,3-butadiene. DEB is considered a carcinogen mainly due to its high potential as clastogen, which induces structural chromosome aberrations such as sister chromatid exchanges, chromosomal breaks, and micronuclei. Due to its clastogenic effect, DEB is one of the most used agents for diagnostic studies of Fanconi anemia, a recessively inherited disease related to mutations affecting several genes involved in a common DNA repair pathway. When performing Fanconi anemia diagnostic tests in our laboratory, we have observed occasional multipolar mitosis (MM) in lymphocyte cultures exposed to 0.1 μg/ml of DEB and harvested in the absence of any mitotic spindle inhibitor. Although previous studies reported an aneugenic effect (i.e. it induces aneuploidy) of DEB, no mechanism was suggested to explain such observations. Therefore, the aim of this study was to investigate whether exposure to 0.1 μg/ml of DEB is significantly associated with the occurrence of MM. We blindly assessed the frequency of MM in lymphocyte cultures from 10 nonsmoking healthy individuals. Two series of 3 cultures were performed from each sample under different conditions: A, without DEB; B, with 0.1 μg/ml of DEB, and C, with 25 μM of mitomycin C as positive control. Cultures exposed to DEB showed higher frequencies of MM (23 of 2,000 cells) than did the unexposed ones (3 of 2,000 cells).

Mitotic index and multipolar mitosis in routine histologic sections as prognostic markers of pancreatic cancers: A clinicopathological study

Pancreatology ◽  
2016 ◽  
Vol 16 (1) ◽  
pp. 127-132 ◽  
Author(s):  
Yoko Matsuda ◽  
Hisashi Yoshimura ◽  
Toshiyuki Ishiwata ◽  
Hiroki Sumiyoshi ◽  
Akira Matsushita ◽  
...  
Keyword(s):  
Mitotic Index ◽  
Prognostic Markers ◽  
Multipolar Mitosis ◽  
Pancreatic Cancers ◽  
Clinicopathological Study

Chromosome segregation from cell hybrids. IV. Movement and position of segregant set chromosomes in early-phase interspecific cell hybrids

1988 ◽  
Vol 89 (1) ◽  
pp. 49-56
Author(s):  
P.A. Zelesco ◽  
J.A. Graves
Keyword(s):  
Chromosome Segregation ◽  
Early Phase ◽  
Metaphase Plate ◽  
Central Position ◽  
Chromosome Loss ◽  
Human Chromosomes ◽  
Hybrid Cells ◽  
Multipolar Mitosis ◽  
Cell Hybrids ◽  
G 11

We searched for evidence of aberrant movement or position of segregant set chromosomes in C-banded and G-11-banded early-phase hamster-mouse and hamster-human cell hybrids that had been prepared with minimal disruption. No evidence was obtained for an increased frequency of multipolar mitosis, delayed or precocious metaphase congression or anaphase segregation, or for exclusion of chromosomes from the daughter nuclei. However, in hamster-human hybrids, segregant set (human) chromosomes were observed to assume a central position within a ring of hamster chromosomes on the metaphase plate. Such non-random positioning may imply that the centromeres of segregant chromosomes make aberrant, or simply less efficient, attachments to the spindle in hybrid cells. This aberrant position may perhaps result indirectly in chromosome loss by interfering with the normal processes of replication, repair or transcription.

scholarly journals DDX3 localizes to the centrosome and prevents multipolar mitosis by epigenetically and translationally modulating p53 expression

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Wei-Ju Chen ◽  
Wei-Ting Wang ◽  
Tsung-Yuan Tsai ◽  
Hao-Kang Li ◽  
Yan-Hwa Wu Lee
Keyword(s):  
P53 Expression ◽  
Multipolar Mitosis

Euploid segregation through multipolar mitosis in mammalian cell cultures

Chromosoma ◽  
1974 ◽  
Vol 45 (2) ◽  
pp. 151-162 ◽  
Author(s):  
Marco Rizzoni ◽  
Fabrizio Palitti ◽  
Paolo Perticone
Keyword(s):  
Mammalian Cell ◽  
Cell Cultures ◽  
Multipolar Mitosis ◽  
Mammalian Cell Cultures

scholarly journals Choice between 1- and 2-furrow cytokinesis in Caenorhabditis elegans embryos with tripolar spindles

2019 ◽  
Vol 30 (16) ◽  
pp. 2065-2075 ◽  
Author(s):  
Tomo Kondo ◽  
Akatsuki Kimura
Keyword(s):  
Caenorhabditis Elegans ◽  
Cell Shape ◽  
Live Cell Imaging ◽  
Cell Imaging ◽  
Embryonic Cells ◽  
Normal Cells ◽  
Multipolar Mitosis ◽  
Multipolar Spindles ◽  
Pulling Forces ◽  
Mutant Cells

Excessive centrosomes often lead to multipolar spindles, and thus probably to multipolar mitosis and aneuploidy. In Caenorhabditis elegans, ∼70% of the paternal emb-27APC6 mutant embryonic cells contained more than two centrosomes and formed multipolar spindles. However, only ~30% of the cells with tripolar spindles formed two cytokinetic furrows. The rest formed one furrow, similar to normal cells. To investigate the mechanism via which cells avoid forming two cytokinetic furrows even with a tripolar spindle, we conducted live-cell imaging in emb-27APC6 mutant cells. We observed that the chromatids were aligned on only two of the three sides of the tripolar spindle, and the angle of the tripolar spindle relative to the long axis of the cell correlated with the number of cytokinetic furrows. Our numerical modeling showed that the combination of cell shape, cortical pulling forces, and heterogeneity of centrosome size determines whether cells with a tripolar spindle form one or two cytokinetic furrows.

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