scholarly journals Epigenetic Regulation of miRNA-211 by MMP-9 Governs Glioma Cell Apoptosis, Chemosensitivity and Radiosensitivity

Oncotarget ◽  
2012 ◽  
Vol 3 (11) ◽  
pp. 1439-1454 ◽  
Author(s):  
Swapna Asuthkar ◽  
Kiran Kumar Velpula ◽  
Chandramu Chetty ◽  
Bharathi Gorantla ◽  
Jasti S. Rao
Keyword(s):  
Epigenetic Regulation ◽  
Cell Apoptosis ◽  
Glioma Cell

scholarly journals Trimebutine Promotes Glioma Cell Apoptosis as a Potential Anti-tumor Agent

2018 ◽  
Vol 9 ◽  
Author(s):  
Yi-pu Fan ◽  
Pei Liu ◽  
Wei-kang Xue ◽  
Wei-jiang Zhao ◽  
Hong-chao Pan
Keyword(s):  
Cell Apoptosis ◽  
Glioma Cell ◽  
Tumor Agent

Characterizing the Role of PCDH9 in the Regulation of Glioma Cell Apoptosis and Invasion

2013 ◽  
Vol 52 (2) ◽  
pp. 250-260 ◽  
Author(s):  
Chunlin Wang ◽  
Bangbao Tao ◽  
Shiting Li ◽  
Bing Li ◽  
Xiaoqiang Wang ◽  
...  
Keyword(s):  
Cell Apoptosis ◽  
Glioma Cell

scholarly journals HDAC inhibitor, scriptaid, induces glioma cell apoptosis through JNK activation and inhibits telomerase activity

2009 ◽  
Vol 14 (8) ◽  
pp. 2151-2161 ◽  
Author(s):  
Vivek Sharma ◽  
Nitin Koul ◽  
Christy Joseph ◽  
Deobrat Dixit ◽  
Sadashib Ghosh ◽  
...  
Keyword(s):  
Hdac Inhibitor ◽  
Cell Apoptosis ◽  
Glioma Cell ◽  
Telomerase Activity ◽  
Jnk Activation

scholarly journals Long noncoding RNA UBE2R2-AS1 promotes glioma cell apoptosis via targeting the miR-877-3p/TLR4 axis

2019 ◽  
Vol Volume 12 ◽  
pp. 3467-3480 ◽  
Author(s):  
Wu Xu ◽  
Guo-Qing Hu ◽  
Clive Da Costa ◽  
Jun-Hai Tang ◽  
Qing-Rui Li ◽  
...  
Keyword(s):  
Cell Apoptosis ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Glioma Cell

Glial-specific retrovirally mediated gas1 gene expression induces glioma cell apoptosis and inhibits tumor growth in vivo

2004 ◽  
Vol 15 (3) ◽  
pp. 483-491 ◽  
Author(s):  
Absalom Zamorano ◽  
Britt Mellström ◽  
Paula Vergara ◽  
José R Naranjo ◽  
José Segovia
Keyword(s):  
Gene Expression ◽  
Tumor Growth ◽  
Cell Apoptosis ◽  
Glioma Cell

Calcium overload induces C6 rat glioma cell apoptosis in sonodynamic therapy

2011 ◽  
Vol 87 (10) ◽  
pp. 1061-1066 ◽  
Author(s):  
Jian-Hua Li ◽  
Wu Yue ◽  
Zheng Huang ◽  
Zhi-Qiang Chen ◽  
Qi Zhan ◽  
...  
Keyword(s):  
Cell Apoptosis ◽  
Glioma Cell ◽  
Calcium Overload ◽  
Sonodynamic Therapy ◽  
Rat Glioma

scholarly journals miR-103/miR-195/miR-15b Regulate SALL4 and Inhibit Proliferation and Migration in Glioma

Molecules ◽  
2018 ◽  
Vol 23 (11) ◽  
pp. 2938 ◽  
Author(s):  
Li-Ping Chen ◽  
Na-Na Zhang ◽  
Xue-Qing Ren ◽  
Jie He ◽  
Yu Li
Keyword(s):  
Cell Proliferation ◽  
Cell Apoptosis ◽  
Glioma Cell ◽  
Inverse Correlation ◽  
Primary Brain Tumor ◽  
Migration And Invasion ◽  
Glioma Cell Proliferation ◽  
The Common ◽  
Direct Target ◽  
And Migration

Glioma is the common highly malignant primary brain tumor. However, the molecular pathways that result in the pathogenesis of glioma remain elusive. In this study, we found that microRNA-103 (miR-103), microRNA-195 (miR-195), or microRNA-15b (miR-15b), which all have the same 5′ “seed” miRNA portion and share common binding sites in the SALL4 3′-untranslated region (UTR), were downregulated in glioma tissues and cell lines. These miRNAs suppressed glioma cell proliferation, migration, and invasion, induced cell apoptosis, and decreased the level of the SALL4 protein, but not that of SALL4 mRNA, which was identified as a direct target of all three miRNAs. The caspase-3/7 activity expression in U251 cells overexpressing these miRNAs was rescued during SALL4 upregulation. An obvious inverse correlation was observed between SALL4 and miR-103 or miR-195 expression levels in clinical glioma samples. Moreover, enforced expression of SALL4 stimulated cell proliferation, migration, and invasion. In conclusion, these data suggest that miR-103, miR-195, and miR-15b post-transcriptionally downregulated the expression of SALL4 and suppressed glioma cell growth, migration, and invasion, and increased cell apoptosis. These results provide a potential therapeutic target that may downregulate SALL4 in glioma.

scholarly journals A Novel Gene RNF138 Expressed in Human Gliomas and Its Function in the Glioma Cell Line U251

2012 ◽  
Vol 35 (3) ◽  
pp. 167-178 ◽  
Author(s):  
You-xin Zhou ◽  
San-song Chen ◽  
Ting-feng Wu ◽  
Da-dong Ding ◽  
Xiong-hui Chen ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Proliferation ◽  
Cell Line ◽  
Brain Tissue ◽  
Cell Lines ◽  
Cell Apoptosis ◽  
Glioma Cell ◽  
Glioma Cell Line ◽  
Glioma Tissue ◽  
Glioma Cell Lines

Background: The gliomas represent the most common primary malignant brain tumors; however, little is known about the molecular pathogenesis of these tumors. Recent research reveals that the oncogenesis and development of gliomas have a close relation to the overexpression of several oncogenes and the inactivation of tumor suppressor genes. Whether the RING finger protein, RNF138, a newly discovered protein, plays a role in glioma oncogenesis is unknown. The present study investigates the expression levels of RNF138 mRNA in glioma samples and noncancerous brain samples and its function in the human glioma cell line U251.Methods: RT-PCR was used to ascertain the expression of RNF138 mRNA in the glioma cell lines U251, SHG44, U87, A172, and U373. The RNF138 mRNA expression levels of 35 pathological confirmed glioma samples (Grade I – 4 cases, Grade II – 13 cases, Grade III – 11 cases, and Grade IV – 7 cases) and five noncancerous brain tissue samples were analyzed by real-time quantitative PCR. By RNA interference (RNAi) with the lentivirus vector system, the expression of RNF138 was inhibited in the human astrocytomas-glioblastoma multiforme cell line U251. The effects of RNF138-knockdown on cell proliferation were assessed by Cellomics, and cell cycle and cell apoptosis were assessed by FACS.Results: The RNF138 mRNA is expressed in the five glioma cell lines, and its expression level is significantly higher in glioma tissue than in noncancerous brain tissue. By down-regulation of RNF138 expression, U251 cell proliferation was inhibited and cell apoptosis increased. At the same time, S stage cells lessened and G2 stage cells increased.Conclusion: The RNF138 gene is highly expressed in glioma tissue and glioma cell lines. It plays an important role in glioma cell proliferation, apoptosis, and cell cycle.

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