Novel histone deacetylase inhibitor MPT0G009 induces cell apoptosis and synergistic anticancer activity with tumor necrosis factor-related apoptosis-inducing ligand against human hepatocellular carcinoma

Mei-Chuan Chen; Hui-Hsuan Huang; Chin-Yu Lai; Yi-Jyun Lin; Jing-Ping Liou; Mei-Jung Lai; Yu-Hsuan Li; Che-Ming Teng; Chia-Ron Yang

doi:10.18632/oncotarget.6352

Novel histone deacetylase inhibitor MPT0G009 induces cell apoptosis and synergistic anticancer activity with tumor necrosis factor-related apoptosis-inducing ligand against human hepatocellular carcinoma

Oncotarget ◽

10.18632/oncotarget.6352 ◽

2015 ◽

Vol 7 (1) ◽

pp. 402-417 ◽

Cited By ~ 11

Author(s):

Mei-Chuan Chen ◽

Hui-Hsuan Huang ◽

Chin-Yu Lai ◽

Yi-Jyun Lin ◽

Jing-Ping Liou ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Tumor Necrosis Factor ◽

Anticancer Activity ◽

Histone Deacetylase ◽

Cell Apoptosis ◽

Histone Deacetylase Inhibitor ◽

Tumor Necrosis ◽

Human Hepatocellular Carcinoma ◽

Deacetylase Inhibitor ◽

Necrosis Factor

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Involvement of the tumor necrosis factor (TNF)/TNF receptor system in leukemic cell apoptosis induced by histone deacetylase inhibitor depsipeptide (FK228)

Journal of Cellular Physiology ◽

10.1002/jcp.20235 ◽

2005 ◽

Vol 203 (2) ◽

pp. 387-397 ◽

Cited By ~ 33

Author(s):

Krittaya Sutheesophon ◽

Noriko Nishimura ◽

Yukiko Kobayashi ◽

Yutaka Furukawa ◽

Mikihiko Kawano ◽

...

Keyword(s):

Tumor Necrosis Factor ◽

Histone Deacetylase ◽

Cell Apoptosis ◽

Histone Deacetylase Inhibitor ◽

Tumor Necrosis ◽

Leukemic Cell ◽

Tnf Receptor ◽

Receptor System ◽

Deacetylase Inhibitor ◽

Necrosis Factor

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Cotreatment with Histone Deacetylase Inhibitor LAQ824 Enhances Apo-2L/Tumor Necrosis Factor-Related Apoptosis Inducing Ligand-Induced Death Inducing Signaling Complex Activity and Apoptosis of Human Acute Leukemia Cells

Cancer Research ◽

10.1158/0008-5472.can-03-2629 ◽

2004 ◽

Vol 64 (7) ◽

pp. 2580-2589 ◽

Cited By ~ 151

Author(s):

Fei Guo ◽

Celia Sigua ◽

Jianguo Tao ◽

Purva Bali ◽

Prince George ◽

...

Keyword(s):

Tumor Necrosis Factor ◽

Acute Leukemia ◽

Histone Deacetylase ◽

Histone Deacetylase Inhibitor ◽

Tumor Necrosis ◽

Leukemia Cells ◽

Complex Activity ◽

Signaling Complex ◽

Deacetylase Inhibitor ◽

Necrosis Factor

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Abstract 3489: Profound cytotoxicity of the histone deacetylase inhibitor SAHA (Suberoylanilide Hydroxamic Acid) and TRAIL (Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand) combination in malignant pleural mesothelioma

10.1158/1538-7445.am10-3489 ◽

2010 ◽

Author(s):

Javier V. Santos ◽

Alex Vara ◽

Craig Thomas ◽

Medhi Wangpaichitr ◽

Min You ◽

...

Keyword(s):

Tumor Necrosis Factor ◽

Histone Deacetylase ◽

Malignant Pleural Mesothelioma ◽

Histone Deacetylase Inhibitor ◽

Hydroxamic Acid ◽

Tumor Necrosis ◽

Pleural Mesothelioma ◽

Suberoylanilide Hydroxamic Acid ◽

Deacetylase Inhibitor ◽

Necrosis Factor

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Expression of Concern: Melittin, a major component of bee venom, sensitizes human hepatocellular carcinoma cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis by activating CaMKII-TAK1-JNK/p38 and inhibiting IκBα kinase-NFκB.

Journal of Biological Chemistry ◽

10.1074/jbc.ec120.014567 ◽

2020 ◽

Vol 295 (26) ◽

pp. 8880-8880

Keyword(s):

Hepatocellular Carcinoma ◽

Tumor Necrosis Factor ◽

Tumor Necrosis ◽

Carcinoma Cells ◽

Human Hepatocellular Carcinoma ◽

Bee Venom ◽

Hepatocellular Carcinoma Cells ◽

Induced Apoptosis ◽

Human Hepatocellular Carcinoma Cells ◽

Necrosis Factor

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A novel human tumor necrosis factor alfa mutein, F4614, inhibitsin vitro andin vivo growth of murine and human hepatoma: Implication for immunotherapy of human hepatocellular carcinoma

Hepatology ◽

10.1002/hep.510280110 ◽

1998 ◽

Vol 28 (1) ◽

pp. 57-67 ◽

Cited By ~ 5

Author(s):

Yoshinari Atarashi ◽

Satoshi Yasumura ◽

Shuji Nambu ◽

Yukimatsu Yoshio ◽

Jun Murakami ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Tumor Necrosis Factor ◽

Tumor Necrosis ◽

Human Tumor ◽

Human Hepatocellular Carcinoma ◽

Human Hepatoma ◽

Human Tumor Necrosis Factor ◽

Necrosis Factor

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Melittin, a Major Component of Bee Venom, Sensitizes Human Hepatocellular Carcinoma Cells to Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL)-induced Apoptosis by Activating CaMKII-TAK1-JNK/p38 and Inhibiting IκBα Kinase-NFκB

Journal of Biological Chemistry ◽

10.1074/jbc.m807191200 ◽

2008 ◽

Vol 284 (6) ◽

pp. 3804-3813 ◽

Cited By ~ 130

Author(s):

Chen Wang ◽

Taoyong Chen ◽

Ning Zhang ◽

Mingjin Yang ◽

Bai Li ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Tumor Necrosis Factor ◽

Tumor Necrosis ◽

Carcinoma Cells ◽

Human Hepatocellular Carcinoma ◽

Bee Venom ◽

Hepatocellular Carcinoma Cells ◽

Induced Apoptosis ◽

Human Hepatocellular Carcinoma Cells ◽

Necrosis Factor

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The Histone Deacetylase Inhibitor Sodium Butyrate Interacts Synergistically with Phorbol Myristate Acetate (PMA) to Induce Mitochondrial Damage and Apoptosis in Human Myeloid Leukemia Cells through a Tumor Necrosis Factor-α-Mediated Process

Experimental Cell Research ◽

10.1006/excr.2002.5548 ◽

2002 ◽

Vol 277 (1) ◽

pp. 31-47 ◽

Cited By ~ 34

Author(s):

Mohamed Rahmani ◽

Yun Dai ◽

Steven Grant

Keyword(s):

Tumor Necrosis Factor ◽

Histone Deacetylase Inhibitor ◽

Myeloid Leukemia ◽

Tumor Necrosis ◽

Tumor Necrosis Factor Α ◽

Leukemia Cells ◽

Myristate Acetate ◽

Deacetylase Inhibitor ◽

Factor Α ◽

Necrosis Factor

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Galectin-1 Modulates the Survival and Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL) Sensitivity in Human Hepatocellular Carcinoma Cells

Cancer Biotherapy & Radiopharmaceuticals ◽

10.1089/cbr.2015.1857 ◽

2015 ◽

Vol 30 (8) ◽

pp. 336-341 ◽

Cited By ~ 4

Author(s):

Juan Li ◽

Ran-ran Sun ◽

Zu-jiang Yu ◽

Hongxia Liang ◽

Shen Shen ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Tumor Necrosis Factor ◽

Tumor Necrosis ◽

Carcinoma Cells ◽

Human Hepatocellular Carcinoma ◽

Hepatocellular Carcinoma Cells ◽

Human Hepatocellular Carcinoma Cells ◽

Trail Sensitivity ◽

Necrosis Factor

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Withdrawal: Melittin, a major component of bee venom, sensitizes human hepatocellular carcinoma cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis by activating CaMKII-TAK1-JNK/p38 and inhibiting IκBα kinase-NFκB

Journal of Biological Chemistry ◽

10.1016/j.jbc.2021.100767 ◽

2021 ◽

Vol 296 ◽

pp. 100767

Author(s):

Chen Wang ◽

Taoyong Chen ◽

Ning Zhang ◽

Mingjin Yang ◽

Bai Li ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Tumor Necrosis Factor ◽

Tumor Necrosis ◽

Carcinoma Cells ◽

Human Hepatocellular Carcinoma ◽

Bee Venom ◽

Hepatocellular Carcinoma Cells ◽

Induced Apoptosis ◽

Human Hepatocellular Carcinoma Cells ◽

Necrosis Factor

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Expression of Concern: Notch1 signaling sensitizes tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human hepatocellular carcinoma cells by inhibiting Akt/Hdm2-mediated p53 degradation and up-regulating p53-dependent DR5 expression.

Journal of Biological Chemistry ◽

10.1074/jbc.ec120.014568 ◽

2020 ◽

Vol 295 (26) ◽

pp. 8881-8881

Keyword(s):

Hepatocellular Carcinoma ◽

Tumor Necrosis Factor ◽

Tumor Necrosis ◽

Carcinoma Cells ◽

Human Hepatocellular Carcinoma ◽

Hepatocellular Carcinoma Cells ◽

Notch1 Signaling ◽

Induced Apoptosis ◽

Human Hepatocellular Carcinoma Cells ◽

Necrosis Factor

Download Full-text