scholarly journals Mitochondrial DNA copy number in peripheral blood leukocytes and the aggressiveness of localized prostate cancer

Oncotarget ◽  
2015 ◽  
Vol 6 (39) ◽  
pp. 41988-41996 ◽  
Author(s):  
Huakang Tu ◽  
Jian Gu ◽  
Qing H. Meng ◽  
Jeri Kim ◽  
John W. Davis ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Mitochondrial Dna ◽  
Peripheral Blood ◽  
Copy Number ◽  
Localized Prostate Cancer ◽  
Peripheral Blood Leukocytes ◽  
Dna Copy Number ◽  
Blood Leukocytes ◽  
Mitochondrial Dna Copy Number

scholarly journals Mitochondrial DNA copy number in peripheral blood leukocytes is associated with biochemical recurrence in prostate cancer patients in African Americans

2019 ◽  
Vol 41 (3) ◽  
pp. 267-273 ◽  
Author(s):  
Junfeng Xu ◽  
Wen-Shin Chang ◽  
Chia-Wen Tsai ◽  
Da-Tian Bau ◽  
John W Davis ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Mitochondrial Dna ◽  
Peripheral Blood ◽  
Biochemical Recurrence ◽  
Copy Number ◽  
Peripheral Blood Leukocytes ◽  
Dna Copy Number ◽  
Blood Leukocytes ◽  
Mitochondrial Dna Copy Number ◽  
Significant Difference

Abstract Mitochondria play multiple important cellular functions. The purpose of this study was to evaluate whether leukocyte mitochondrial DNA copy number (mtDNAcn) is associated with aggressive prostate cancer (PCa) in African American (AA) men. We measured the mtDNAcn in peripheral blood leukocytes from 317 localized AA PCa patients and evaluated its associations with aggressive disease features at diagnosis and biochemical recurrence (BCR) after treatments. There was no significant difference in mtDNAcn among the clinical features at diagnosis, including age, prostate-specific antigen level, Gleason score and clinical stage under analysis of variance test. However, mtDNAcn was significantly associated with BCR in multivariate Cox analysis. Dichotomized into low and high mtDNAcn groups by the median value of mtDNAcn, patients with low mtDNAcn exhibited a significantly lower risk of BCR (hazard ratio = 0.32, 95% confidence interval: 0.13–0.79) compared to those with high mtDNAcn. There was a significant dose–response in tertile and quartile analyses (P for trend = 0.012 and 0.002, respectively). In Kaplan–Meier survival analyses, patients with higher mtDNAcn exhibited significantly shorter BCR-free survival time than those with lower mtDNAcn in dichotomous, tertile and quartile analyses, with long-rank P values of 0.017, 0.024 and 0.019, respectively. Our results showed for the first time that high leukocyte mtDNAcn was associated with worse prognosis in AA PCa patients.

scholarly journals Peripheral Blood Mitochondrial DNA Copy Number Is Associated with Prostate Cancer Risk and Tumor Burden

PLoS ONE ◽  
2014 ◽  
Vol 9 (10) ◽  
pp. e109470 ◽  
Author(s):  
Weimin Zhou ◽  
Min Zhu ◽  
Ming Gui ◽  
Lihua Huang ◽  
Zhi Long ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Mitochondrial Dna ◽  
Cancer Risk ◽  
Peripheral Blood ◽  
Copy Number ◽  
Prostate Cancer Risk ◽  
Tumor Burden ◽  
Dna Copy Number ◽  
Mitochondrial Dna Copy Number

scholarly journals Mitochondrial DNA copy number in peripheral blood: a potential non-invasive biomarker for female subfertility

2018 ◽  
Vol 35 (11) ◽  
pp. 1987-1994 ◽  
Author(s):  
Andrea Busnelli ◽  
Debora Lattuada ◽  
Raffaella Rossetti ◽  
Alessio Paffoni ◽  
Luca Persani ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Peripheral Blood ◽  
Copy Number ◽  
Dna Copy Number ◽  
Non Invasive ◽  
Mitochondrial Dna Copy Number

scholarly journals Mitochondrial DNA copy number in peripheral blood cells declines with age and is associated with general health among elderly

2014 ◽  
Vol 133 (9) ◽  
pp. 1149-1159 ◽  
Author(s):  
Jonas Mengel-From ◽  
Mikael Thinggaard ◽  
Christine Dalgård ◽  
Kirsten Ohm Kyvik ◽  
Kaare Christensen ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Peripheral Blood ◽  
Blood Cells ◽  
General Health ◽  
Copy Number ◽  
Peripheral Blood Cells ◽  
Dna Copy Number ◽  
Mitochondrial Dna Copy Number
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