scholarly journals Ki67/SATB1 ratio is an independent prognostic factor of overall survival in patients with early hormone receptor-positive invasive ductal breast carcinoma

Oncotarget ◽  
2015 ◽  
Vol 6 (38) ◽  
pp. 41134-41145 ◽  
Author(s):  
Arvydas Laurinavicius ◽  
Andrew R. Green ◽  
Aida Laurinaviciene ◽  
Giedre Smailyte ◽  
Valerijus Ostapenko ◽  
...  
Keyword(s):  
Overall Survival ◽  
Prognostic Factor ◽  
Breast Carcinoma ◽  
Hormone Receptor ◽  
Independent Prognostic Factor ◽  
Invasive Ductal Breast Carcinoma ◽  
Ductal Breast Carcinoma ◽  
Hormone Receptor Positive

Imunohistocheminių biožymenų tyrimai hormonų receptorių teigiamos duktalinės krūties karcinomos mikroaplinkos erdviniame kontekste skaitmeninės vaizdo analizės metodu

2021 ◽  
Author(s):  
◽  
Dovilė Žilėnaitė
Keyword(s):  
Image Analysis ◽  
Breast Carcinoma ◽  
Digital Image ◽  
Hormone Receptor ◽  
Digital Image Analysis ◽  
Spatial Context ◽  
Ductal Breast Carcinoma ◽  
Hormone Receptor Positive

Assessing immunohistochemistry biomarkers in the spatial context of the microenvironment of hormone receptor-positive ductal breast carcinoma by digital image analysis

FOXP3 Expression and Overall Survival in Breast Cancer

2009 ◽  
Vol 27 (11) ◽  
pp. 1746-1752 ◽  
Author(s):  
Andrea Merlo ◽  
Patrizia Casalini ◽  
Maria Luisa Carcangiu ◽  
Chiara Malventano ◽  
Tiziana Triulzi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Overall Survival ◽  
Prognostic Factor ◽  
Breast Carcinoma ◽  
Survival Probability ◽  
Expression Patterns ◽  
Foxp3 Expression ◽  
Independent Prognostic Factor ◽  
Free Survival ◽  
Node Positive

Purpose The transcription factor forkhead box P3 (FOXP3) up- or downregulates a large number of genes and has been recently reported to be expressed in tumor cells. We investigated the prognostic importance of FOXP3 expression in patients with breast cancer. Patients and Methods The expression patterns of FOXP3 were characterized by immunohistochemistry in primary breast carcinoma specimens from patients of the Milan 3 and 1 trials. Kaplan-Meier analysis and Cox proportional hazards regression modeling were used to assess the overall survival, distant metastasis-free survival, and local relapse cumulative incidence, according to the presence or absence of FOXP3 expression. Results FOXP3 expression in tumors was associated with worse overall survival probability and the risk increased with increasing FOXP3 immunostaining intensity. FOXP3 was also a strong prognostic factor for distant metastases-free survival but not for local recurrence risk. In multivariate analysis FOXP3 resulted an independent prognostic factor and the hazard ratio of FOXP3 expression and of lymph node positivity were similar. In the Milan 3 trial, the probability of 10-year survival in node-negative subgroup was 100% for FOXP3-negative and 82% for FOXP3-positive patients; in node-positive subgroup 82% for FOXP3-negative and 41% for FOXP3-positive patients. Even in the Milan 1 trial the lack of FOXP3 expression in node-positive subgroup was related to a significantly better prognosis than in FOXP3-positive patients (10-year survival probability, 89% v 59%). Conclusion The data identify FOXP3 expression as a new independent prognostic factor in breast carcinoma, which might help to improve the selection of patients for appropriate therapy.

scholarly journals Bimodality of intratumor Ki67 expression is an independent prognostic factor of overall survival in patients with invasive breast carcinoma

2016 ◽  
Vol 468 (4) ◽  
pp. 493-502 ◽  
Author(s):  
Arvydas Laurinavicius ◽  
Benoit Plancoulaine ◽  
Allan Rasmusson ◽  
Justinas Besusparis ◽  
Renaldas Augulis ◽  
...  
Keyword(s):  
Overall Survival ◽  
Prognostic Factor ◽  
Breast Carcinoma ◽  
Independent Prognostic Factor ◽  
Invasive Breast Carcinoma ◽  
Ki67 Expression

scholarly journals Cytoplasmic HuR Expression Is a Prognostic Factor in Invasive Ductal Breast Carcinoma

2005 ◽  
Vol 65 (6) ◽  
pp. 2157-2161 ◽  
Author(s):  
Mira Heinonen ◽  
Petri Bono ◽  
Kirsi Narko ◽  
Sung-Hee Chang ◽  
Johan Lundin ◽  
...  
Keyword(s):  
Prognostic Factor ◽  
Breast Carcinoma ◽  
Invasive Ductal Breast Carcinoma ◽  
Ductal Breast Carcinoma

Challenges in the correct assessment of a case of aggressive thyroid carcinoma with synchronous breast cancer, case report and review of the literature: essential role of radiopharmaceuticals

2020 ◽  
Vol 13 ◽  
Author(s):  
Andra Piciu ◽  
Alexandru Mester ◽  
George Rusu ◽  
Doina Piciu
Keyword(s):  
Breast Cancer ◽  
Papillary Thyroid Carcinoma ◽  
Breast Carcinoma ◽  
Thyroid Carcinoma ◽  
Bone Metastases ◽  
Essential Role ◽  
Papillary Thyroid ◽  
Invasive Ductal Breast Carcinoma ◽  
Ductal Breast Carcinoma

Background: Thyroid carcinoma represents a complex pathology that can still be considered a medical challenge, despite having a better prognosis and life expectancy than most other neoplasms, also the scenario of multiple malignancies involving thyroid cancer is nowadays a common reality. Materials and methods: We reviewed the literature regarding the aggressive presentation of synchronous thyroid and breast cancer. In the current paper we are reporting the case of a 59 years-old woman, diagnosed with invasive ductal breast carcinoma and papillary thyroid carcinoma, presenting a natural history of both aggressive synchronous tumors. At the moment of hospitalization, the diagnostic was breast carcinoma with multiple secondary lesions, suggestive for lung and bone metastases, and nodular goiter. Results: Searching the literature PUBMED with the terms “thyroid carcinoma and synchronous breast carcinoma we found 86 studies; introducing the term “aggressive” the result included 4 studies, among them none being relevant for aggressive and synchronous. A similar search was done in SCOPUS finding 92 documents and after introducing the term aggressive, the number of papers was 8, none being for the synchronous aggressive metastatic thyroid and breast carcinoma. The majority of imaging diagnostic tools were used in this particular medical case, in order to ensure the best potential outcome. The final diagnostic was papillary thyroid carcinoma with lung and unusual multiple bone metastases and synchronous invasive ductal breast carcinoma with subcutaneous metastases. Conclusion: The case illustrates the challenges in correct assessment of oncologic patients, despite the advances in medical imaging and technologies and underlines the essential role of nuclear medicine procedures in the diagnostic and therapy protocols.

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