scholarly journals Heterogeneity revealed by integrated genomic analysis uncovers a molecular switch in malignant uveal melanoma

Oncotarget ◽  
2015 ◽  
Vol 6 (35) ◽  
pp. 37824-37835 ◽  
Author(s):  
Mark J. de Lange ◽  
Sake I. van Pelt ◽  
Mieke Versluis ◽  
Ekaterina S. Jordanova ◽  
Wilma G.M. Kroes ◽  
...  
Keyword(s):  
Uveal Melanoma ◽  
Genomic Analysis ◽  
Molecular Switch ◽  
Malignant Uveal Melanoma

scholarly journals Role of epigenetic deregulation in hematogenous dissemination of malignant uveal melanoma

Neoplasma ◽  
2018 ◽  
Vol 65 (06) ◽  
pp. 840-854 ◽  
Author(s):  
B. Smolkova ◽  
V. Horvathova Kajabova ◽  
I. Zmetakova ◽  
L. Kalinkova ◽  
G. Czanner ◽  
...  
Keyword(s):  
Uveal Melanoma ◽  
Hematogenous Dissemination ◽  
Malignant Uveal Melanoma

Proton Irradiation of Malignant Uveal Melanoma

1998 ◽  
Vol 103 (3) ◽  
pp. 203-211 ◽  
Author(s):  
Peter Naeser ◽  
Erik Blomquist ◽  
Anders Montelius ◽  
Karl-Åke Thoumas
Keyword(s):  
Uveal Melanoma ◽  
Proton Irradiation ◽  
Malignant Uveal Melanoma

Malignant uveal melanoma and similar lesions studied by computed tomography.

Radiology ◽  
1985 ◽  
Vol 156 (2) ◽  
pp. 403-408 ◽  
Author(s):  
M F Mafee ◽  
G A Peyman ◽  
M A McKusick
Keyword(s):  
Computed Tomography ◽  
Uveal Melanoma ◽  
Malignant Uveal Melanoma

scholarly journals Epigenetic Changes in Malignant Uveal Melanoma and Possibilities of Their Therapeutic Targeting

2020 ◽  
Vol 76 (2) ◽  
pp. 103-110
Author(s):  
Božena Smolková ◽  
Lucia Demková
Keyword(s):  
Uveal Melanoma ◽  
Histone Deacetylase Inhibitors ◽  
Treatment Strategies ◽  
Epigenetic Changes ◽  
Cycle Arrest ◽  
Risk Patients ◽  
New Treatment ◽  
Malignant Uveal Melanoma ◽  
Traditional Approaches ◽  
Effective Drugs

Uveal melanoma (UM) is a deadly cancer that leads to metastatic disease in more than 50 % of the patients. Despite the improvement in the treatment of primary disease, there is still no effective therapy to prevent the development of metastases. Therefore, the disease requires intensive research to identify new treatment strategies. In preclinical UM models, epigenetic drugs have been shown to increase the sensitivity of resistant tumour cells to treatment. The successful use of histone deacetylase inhibitors, which induced cell cycle arrest, reprogramming consistent with melanocyte differentiation and inhibition of tumour growth in preclinical models, demonstrates the role of epigenetic regulation in UM metastasis. Identification of epigenetic changes associated with UM development an progression could contribute to the discovery of more effective drugs that, in combination with traditional approaches, may yield better therapeutic results for high-risk patients.

Very Long-Term Prognosis of Patients with Malignant Uveal Melanoma

2003 ◽  
Vol 44 (11) ◽  
pp. 4651 ◽  
Author(s):  
Emma Kujala ◽  
Teemu Ma¨kitie ◽  
Tero Kivela¨
Keyword(s):  
Uveal Melanoma ◽  
Long Term Prognosis ◽  
Malignant Uveal Melanoma

scholarly journals Cystatin C and cystatin SN as possible soluble tumor markers in malignant uveal melanoma

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Maria A. Dikovskaya ◽  
Galina S. Russkikh ◽  
Konstantin V. Loktev ◽  
Thomas P. Johnston ◽  
Margarita M. Gevorgyan ◽  
...  
Keyword(s):  
Uveal Melanoma ◽  
Cystatin C ◽  
Cerebral Spinal Fluid ◽  
Biological Fluids ◽  
Tear Fluid ◽  
Healthy Controls ◽  
Malignant Uveal Melanoma ◽  
Cystatin Sn ◽  
Intraocular Fluid

Abstract Background The aim of the study was to determine the concentration of endogenous cystatin C and cystatin SN, as potential tumor biomarkers, in the serum and biological fluids of the eye in both healthy controls and patients with uveal melanoma. Patients and methods The concentration of both cystatins was determined in the intraocular fluid (IOF), tear fluid, and serum of patients with uveal melanoma and compared to baseline measurements in IOF, tears, serum, cerebral spinal fluid, saliva and urine of healthy controls. Results The concentration of cystatin C in all the biological matrices obtained from healthy controls significantly exceeded the concentration of cystatin SN and was independent of gender. Cystatin C concentrations in the tear fluid of patients with uveal melanoma (both the eye with the malignancy, as well as the contralateral, non-affected eye), were significantly greater than cystatin C concentrations in the tear fluid of healthy controls and was independent of tumor size. The concentration of cystatin SN in IOF of patients with uveal melanoma was significantly less than the corresponding concentration of cystatin SN in healthy controls. Conclusions The ratio of cystatins (CysC:CysSN) in both the serum and tear fluid, as well as the concentration of cystatin SN in IOF, would appear to strongly suggest the presence of uveal melanoma. It is further suggested that multiple diagnostic criteria be utilized if a patient is suspected of having uveal melanoma, such as determination of the cystatin C and cystatin SN concentrations in serum, tears, and IOF, ocular fundus and ultrasound imaging, and biopsy with histopathological evaluation.

scholarly journals CANT1 lncRNA Triggers Efficient Therapeutic Efficacy by Correcting Aberrant lncing Cascade in Malignant Uveal Melanoma

2017 ◽  
Vol 25 (5) ◽  
pp. 1209-1221 ◽  
Author(s):  
Yue Xing ◽  
Xuyang Wen ◽  
Xia Ding ◽  
Jiayan Fan ◽  
Peiwei Chai ◽  
...  
Keyword(s):  
Uveal Melanoma ◽  
Therapeutic Efficacy ◽  
Malignant Uveal Melanoma
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