scholarly journals Sox9 is required for prostate development and prostate cancer initiation

Oncotarget ◽  
2012 ◽  
Vol 3 (6) ◽  
pp. 651-663 ◽  
Author(s):  
Zhenhua Huang ◽  
Paula J Hurley ◽  
Brian W Simons ◽  
Luigi Marchionni ◽  
David M Berman ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Prostate Development ◽  
Cancer Initiation

scholarly journals Androgens and androgen receptor signaling in prostate tumorigenesis

2014 ◽  
Vol 54 (1) ◽  
pp. R15-R29 ◽  
Author(s):  
Ye Zhou ◽  
Eric C Bolton ◽  
Jeremy O Jones
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Cancer Cells ◽  
Cancer Growth ◽  
Castration Resistant Prostate Cancer ◽  
Prostate Cancer Cells ◽  
Prostate Tumorigenesis ◽  
Prostate Development ◽  
Cancer Initiation

Androgens and androgen receptor (AR) signaling are necessary for prostate development and homeostasis. AR signaling also drives the growth of nearly all prostate cancer cells. The role of androgens and AR signaling has been well characterized in metastatic prostate cancer, where it has been shown that prostate cancer cells are exquisitely adept at maintaining functional AR signaling to drive cancer growth. As androgens and AR signaling are so intimately involved in prostate development and the proliferation of advanced prostate cancer, it stands to reason that androgens and AR are also involved in prostate cancer initiation and the early stages of cancer growth, yet little is known of this process. In this review, we summarize the current state of knowledge concerning the role of androgens and AR signaling in prostate tissue, from development to metastatic, castration-resistant prostate cancer, and use that information to suggest potential roles for androgens and AR in prostate cancer initiation.

scholarly journals The many ways to make a luminal cell and a prostate cancer cell

2015 ◽  
Vol 22 (6) ◽  
pp. T187-T197 ◽  
Author(s):  
Douglas W Strand ◽  
Andrew S Goldstein
Keyword(s):  
Prostate Cancer ◽  
Stem Cell ◽  
Prostate Cancer Cell ◽  
Stem Cell Differentiation ◽  
Cell Populations ◽  
Self Renewal ◽  
Signaling Mechanisms ◽  
Cancer Initiation ◽  
The Many ◽  
Multiple Cells

Research in the area of stem/progenitor cells has led to the identification of multiple stem-like cell populations implicated in prostate homeostasis and cancer initiation. Given that there are multiple cells that can regenerate prostatic tissue and give rise to prostate cancer, our focus should shift to defining the signaling mechanisms that drive differentiation and progenitor self-renewal. In this article, we will review the literature, present the evidence and raise important unanswered questions that will help guide the field forward in dissecting critical mechanisms regulating stem-cell differentiation and tumor initiation.

scholarly journals 2185 The effects of autoimmune inflammation on proliferation, differentiation, and androgen receptor signaling in adult prostate stem cells

2018 ◽  
Vol 2 (S1) ◽  
pp. 31-31
Author(s):  
Paula Cooper ◽  
Hsing-Hui Wang ◽  
Meaghan Broman ◽  
Emery Goossens ◽  
Hristos Kaimakliotis ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Stem Cells ◽  
Androgen Receptor ◽  
3D Cell Culture ◽  
Androgen Receptor Signaling ◽  
Autoimmune Inflammation ◽  
Cancer Initiation ◽  
Study Population ◽  
Tissue Recombination ◽  
Survival Mechanisms

OBJECTIVES/SPECIFIC AIMS: The primary goal of this project is to verify findings from a murine prostatitis model in the human setting. METHODS/STUDY POPULATION: Methods include primary cell isolation and culture, FACS, adoptive transfer, 3D cell culture, histology, immunofluorescence, xenograft, and tissue recombination. The study population includes patients undergoing HoLEP or radical prostatectomy due to hyperplasia or adjacent bladder or prostate cancer. RESULTS/ANTICIPATED RESULTS: Having verified similar sensitivities to androgen receptor (AR) inhibitors between naive murine and human basal prostate stem cells, we anticipate that autoimmune inflammation in humans affects the response of basal prostate stem cells in a manner similar to the murine setting as well. This includes increased proliferation, increased differentiation, and decreased response to AR inhibitors. DISCUSSION/SIGNIFICANCE OF IMPACT: The identification of survival mechanisms used by basal prostate stem cells in an androgen deprived environment may give insight to the process by which prostate cancer becomes androgen independent. The effect of inflammation on proliferation, survival, and AR signaling in these cells may also provide information relevant to cancer initiation and progression.

NF-κB signaling promotes castration-resistant prostate cancer initiation and progression

2020 ◽  
Vol 211 ◽  
pp. 107538
Author(s):  
Shayna E. Thomas-Jardin ◽  
Haley Dahl ◽  
Afshan F. Nawas ◽  
Monica Bautista ◽  
Nikki A. Delk
Keyword(s):  
Prostate Cancer ◽  
Castration Resistant Prostate Cancer ◽  
Castration Resistant ◽  
Cancer Initiation

scholarly journals The evolution of long noncoding RNA acceptance in prostate cancer initiation, progression, and its clinical utility in disease management

2019 ◽  
Vol 76 (5) ◽  
pp. 546-559 ◽  
Author(s):  
Varune Rohan Ramnarine ◽  
Maxim Kobelev ◽  
Ewan A. Gibb ◽  
Mannan Nouri ◽  
Dong Lin ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Disease Management ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Clinical Utility ◽  
Cancer Initiation

PrLZ Is Expressed in Normal Prostate Development and in Human Prostate Cancer Progression

2007 ◽  
Vol 13 (20) ◽  
pp. 6040-6048 ◽  
Author(s):  
Ruoxiang Wang ◽  
Jianchun Xu ◽  
Nicola Mabjeesh ◽  
Guodong Zhu ◽  
Jianguang Zhou ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Progression ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Prostate Cancer Progression ◽  
Normal Prostate ◽  
Prostate Development

scholarly journals Bisphenol A and its analogues disrupt centrosome cycle and microtubule dynamics in prostate cancer

2017 ◽  
Vol 24 (2) ◽  
pp. 83-96 ◽  
Author(s):  
Shuk-Mei Ho ◽  
Rahul Rao ◽  
Sarah To ◽  
Emma Schoch ◽  
Pheruza Tarapore
Keyword(s):  
Prostate Cancer ◽  
Bisphenol A ◽  
Consumer Products ◽  
Microtubule Dynamics ◽  
Serum Starvation ◽  
Cyclin Dependent Kinase ◽  
Microtubule Organization ◽  
Developmental Exposure ◽  
Cancer Initiation ◽  
Structural Analogues

Humans are increasingly exposed to structural analogues of bisphenol A (BPA), as BPA is being replaced by these compounds in BPA-free consumer products. We have previously shown that chronic and developmental exposure to BPA is associated with increased prostate cancer (PCa) risk in human and animal models. Here, we examine whether exposure of PCa cells (LNCaP, C4-2) to low-dose BPA and its structural analogues (BPS, BPF, BPAF, TBBPA, DMBPA and TMBPA) affects centrosome amplification (CA), a hallmark of cancer initiation and progression. We found that exposure to BPA, BPS, DMBPA and TBBPA, in descending order, increased the number of cells with CA, in a non-monotonic dose–response manner. Furthermore, cells treated with BPA and their analogues initiated centrosome duplication at 8 h after release from serum starvation, significantly earlier in G-1 phase than control cells. This response was attended by earlier release of nucleophosmin from unduplicated centrosomes. BPA-exposed cells exhibited increased expression of cyclin-dependent kinaseCDK6and decreased expression of CDK inhibitors (p21Waf1/CIP1andp27KIP1). Using specific antagonists for estrogen/androgen receptors, CA in the presence of BPA or its analogues was likely to be mediated via ESR1 signaling. Change in microtubule dynamics was observed on exposure to these analogues, which, for BPA, was accompanied by increased expression of centrosome-associated proteinCEP350. Similar to BPA, chronic treatment of cells with DMBPA, but not other analogues, resulted in the enhancement of anchorage-independent growth. We thus conclude that selected BPA analogues, similar to BPA, disrupt centrosome function and microtubule organization, with DMBPA displaying the broadest spectrum of cancer-promoting effects.

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