scholarly journals PI3K/AKT/mTOR and sonic hedgehog pathways cooperate together to inhibit human pancreatic cancer stem cell characteristics and tumor growth

Oncotarget ◽  
2015 ◽  
Vol 6 (31) ◽  
pp. 32039-32060 ◽  
Author(s):  
Narinder Sharma ◽  
Rajesh Nanta ◽  
Jay Sharma ◽  
Sumedha Gunewardena ◽  
Karan P. Singh ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Tumor Growth ◽  
Sonic Hedgehog ◽  
Human Pancreatic Cancer

scholarly journals Inhibition of sonic hedgehog pathway and pluripotency maintaining factors regulate human pancreatic cancer stem cell characteristics

2011 ◽  
Vol 131 (1) ◽  
pp. 30-40 ◽  
Author(s):  
Su-Ni Tang ◽  
Junsheng Fu ◽  
Dara Nall ◽  
Mariana Rodova ◽  
Sharmila Shankar ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Sonic Hedgehog ◽  
Hedgehog Pathway ◽  
Human Pancreatic Cancer ◽  
Sonic Hedgehog Pathway

scholarly journals Human Pancreatic Cancer Contains a Side Population Expressing Cancer Stem Cell-Associated and Prognostic Genes

PLoS ONE ◽  
2013 ◽  
Vol 8 (9) ◽  
pp. e73968 ◽  
Author(s):  
Anke Van den broeck ◽  
Hugo Vankelecom ◽  
Wouter Van Delm ◽  
Lies Gremeaux ◽  
Jasper Wouters ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Side Population ◽  
Human Pancreatic Cancer

scholarly journals Author response: HNF1A is a novel oncogene that regulates human pancreatic cancer stem cell properties

2018 ◽  
Author(s):  
Ethan V Abel ◽  
Masashi Goto ◽  
Brian Magnuson ◽  
Saji Abraham ◽  
Nikita Ramanathan ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Author Response ◽  
Human Pancreatic Cancer

scholarly journals Clinical significance and therapeutic implication of CD200 in pancreatic cancer

2019 ◽  
Author(s):  
Shoichi Kinoshita ◽  
Masayuki Sho ◽  
Takahiro Akahori ◽  
Satoshi Nishiwada ◽  
Minako Nagai ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Stem Cell ◽  
Prognostic Factor ◽  
Cancer Stem Cell ◽  
Clinical Significance ◽  
Systemic Therapy ◽  
Stem Cell Marker ◽  
Human Pancreatic Cancer ◽  
Significant Prognostic Factor ◽  
Stem Cell Markers

Abstract Background CD200, a negative T cell regulator as well as a cancer stem cell marker, is a significant prognostic factor and potential therapeutic target in specific cancers. However, the clinical significance of CD200 is unknown in pancreatic ductal adenocarcinoma (PDAC). Methods CD200 was evaluated in 220 resected PDAC patients. Surgery was performed with or without neoadjuvant chemotherapy (NACRT), and adjuvant therapy was administered with systemic therapy or systemic therapy added with hepatic arterial infusion (HAI) therapy. We investigated the clinicopathological outcomes associated with CD200, in relation to the administered multimodal treatment. We further evaluated the impact of the immunological and cancer stem cell properties associated with CD200. Results NACRT patients had a lower average age, lower lymph node metastasis, higher negative surgical margins, and higher HAI administration rate, compared to upfront surgery (US) patients. NACRT was associated with better OS, and higher CD200 expression (66.4% vs. 32.2%, P<0.001) compared to US. CD200 was an independent poor prognostic factor in NACRT (hazard ratio 2.51; 95% confidence interval 1.35-4.66; P = 0.004), but not in US patients. In NACRT patients, the hepatic recurrence rate was relatively high in CD200+ cases despite HAI therapy. CD200 was associated with significantly lower CD4+, CD8+, and CD45RO+ tumor-infiltrating lymphocyte levels. Furthermore, the correlation of CD200 with pancreatic cancer stem cell markers CD44/CD24/ESA was stronger in irradiated human pancreatic cancer cells. Conclusions Our data highlight novel roles for CD200 in immune evasion as well as therapy resistance in pancreatic cancer.

scholarly journals Inhibition of pancreatic cancer stem cell characteristics by α‐Mangostin: Molecular mechanisms involving Sonic hedgehog and Nanog

2019 ◽  
Vol 23 (4) ◽  
pp. 2719-2730 ◽  
Author(s):  
Yiming Ma ◽  
Wei Yu ◽  
Anju Shrivastava ◽  
Rakesh K. Srivastava ◽  
Sharmila Shankar
Keyword(s):  
Pancreatic Cancer ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Sonic Hedgehog ◽  
Molecular Mechanisms
Sign in / Sign up

Export Citation Format

Share Document