scholarly journals MiR-1207 overexpression promotes cancer stem cell-like traits in ovarian cancer by activating the Wnt/β-catenin signaling pathway

Oncotarget ◽  
2015 ◽  
Vol 6 (30) ◽  
pp. 28882-28894 ◽  
Author(s):  
Geyan Wu ◽  
Aibin Liu ◽  
Jinrong Zhu ◽  
Fangyong Lei ◽  
Shu Wu ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Signaling Pathway

scholarly journals Dietary compound proanthocyanidins from Chinese bayberry (Myrica rubraSieb. et Zucc.) leaves attenuate chemotherapy-resistant ovarian cancer stem cell traitsviatargeting the Wnt/β-catenin signaling pathway and inducing G1 cell cycle arrest

2018 ◽  
Vol 9 (1) ◽  
pp. 525-533 ◽  
Author(s):  
Yu Zhang ◽  
Shiguo Chen ◽  
Chaoyang Wei ◽  
Gary O. Rankin ◽  
Xingqian Ye ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Ovarian Cancer ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Cell Cycle Arrest ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Chinese Bayberry ◽  
Cycle Arrest ◽  
G1 Cell Cycle Arrest

Chinese bayberry leaves are found to aid treatment of chemotherapy-resistant cancer cells.

scholarly journals NF-κB Signaling in Ovarian Cancer

Cancers ◽  
2019 ◽  
Vol 11 (8) ◽  
pp. 1182 ◽  
Author(s):  
Brittney S. Harrington ◽  
Christina M. Annunziata
Keyword(s):  
Ovarian Cancer ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Signaling Pathway ◽  
Immune Cells ◽  
Stem Cell Maintenance ◽  
Promote Cell Survival ◽  
Canonical Pathways ◽  
Cancer Cell Population ◽  
Cell Maintenance

The NF-κB signaling pathway is a master and commander in ovarian cancer (OC) that promotes chemoresistance, cancer stem cell maintenance, metastasis and immune evasion. Many signaling pathways are dysregulated in OC and can activate NF-κB signaling through canonical or non-canonical pathways which have both overlapping and distinct roles in tumor progression. The activation of canonical NF-κB signaling has been well established for anti-apoptotic and immunomodulatory functions in response to the tumor microenvironment and the non-canonical pathway in cancer stem cell maintenance and tumor re-initiation. NF-κB activity in OC cells helps to create an immune-evasive environment and to attract infiltrating immune cells with tumor-promoting phenotypes, which in turn, drive constitutive NF-κB activation in OC cells to promote cell survival and metastasis. For these reasons, NF-κB is an attractive target in OC, but current strategies are limited and broad inhibition of this major signaling pathway in normal physiological and immunological functions may produce unwanted side effects. There are some promising pre-clinical outcomes from developing research to target and inhibit NF-κB only in the tumor-reinitiating cancer cell population of OC and concurrently activate canonical NF-κB signaling in immune cells to promote anti-tumor immunity.

scholarly journals Combination of a thioxodihydroquinazolinone with cisplatin eliminates ovarian cancer stem cell-like cells (CSC-LCs) and shows preclinical potential

Oncotarget ◽  
2017 ◽  
Vol 9 (5) ◽  
pp. 6042-6054 ◽  
Author(s):  
Jing Ma ◽  
Joseph Salamoun ◽  
Peter Wipf ◽  
Robert Edwards ◽  
Bennett Van Houten ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Stem Cell ◽  
Cancer Stem Cell

scholarly journals Phase II clinical trial of metformin as a cancer stem cell-targeting agent in ovarian cancer

JCI Insight ◽  
2020 ◽  
Author(s):  
Jason R Brown ◽  
Daniel K. Chan ◽  
Jessica J Shank ◽  
Kent A. Griffith ◽  
Huihui Fan ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Clinical Trial ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Phase Ii ◽  
Phase Ii Clinical Trial ◽  
Cell Targeting
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