scholarly journals Crocetinic acid inhibits hedgehog signaling to inhibit pancreatic cancer stem cells

Oncotarget ◽  
2015 ◽  
Vol 6 (29) ◽  
pp. 27661-27673 ◽  
Author(s):  
Parthasarathy Rangarajan ◽  
Dharmalingam Subramaniam ◽  
Santanu Paul ◽  
Deep Kwatra ◽  
Kanagaraj Palaniyandi ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Hedgehog Signaling ◽  
Pancreatic Cancer Stem Cells

scholarly journals Inhibition of hedgehog signaling depresses self-renewal of pancreatic cancer stem cells and reverses chemoresistance

2012 ◽  
Vol 41 (5) ◽  
pp. 1707-1714 ◽  
Author(s):  
FENG-TING HUANG ◽  
YONG-XUN ZHUAN-SUN ◽  
YAN-YAN ZHUANG ◽  
SHU-LI WEI ◽  
JIAN TANG ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Hedgehog Signaling ◽  
Self Renewal ◽  
Pancreatic Cancer Stem Cells

scholarly journals Chloroquine Targets Pancreatic Cancer Stem Cells via Inhibition of CXCR4 and Hedgehog Signaling

2014 ◽  
Vol 13 (7) ◽  
pp. 1758-1771 ◽  
Author(s):  
Anamaria Balic ◽  
Morten Dræby Sørensen ◽  
Sara Maria Trabulo ◽  
Bruno Sainz ◽  
Michele Cioffi ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Hedgehog Signaling ◽  
Pancreatic Cancer Stem Cells

scholarly journals Integrated lipidomics and proteomics reveal cardiolipin alterations, upregulation of HADHA and long chain fatty acids in pancreatic cancer stem cells

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Claudia Di Carlo ◽  
Bebiana C. Sousa ◽  
Marcello Manfredi ◽  
Jessica Brandi ◽  
Elisa Dalla Pozza ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Stem Cells ◽  
Fatty Acid ◽  
Cancer Stem Cells ◽  
Acyl Chain ◽  
Fatty Acid Elongase ◽  
Acyl Chains ◽  
A Chain ◽  
Pancreatic Cancer Stem Cells ◽  
Long Chain

AbstractPancreatic cancer stem cells (PCSCs) play a key role in the aggressiveness of pancreatic ductal adenocarcinomas (PDAC); however, little is known about their signaling and metabolic pathways. Here we show that PCSCs have specific and common proteome and lipidome modulations. PCSCs displayed downregulation of lactate dehydrogenase A chain, and upregulation of trifunctional enzyme subunit alpha. The upregulated proteins of PCSCs are mainly involved in fatty acid (FA) elongation and biosynthesis of unsaturated FAs. Accordingly, lipidomics reveals an increase in long and very long-chain unsaturated FAs, which are products of fatty acid elongase-5 predicted as a key gene. Moreover, lipidomics showed the induction in PCSCs of molecular species of cardiolipin with mixed incorporation of 16:0, 18:1, and 18:2 acyl chains. Our data indicate a crucial role of FA elongation and alteration in cardiolipin acyl chain composition in PCSCs, representing attractive therapeutic targets in PDAC.

206 Identification and Whole Transcriptome Characterization of Pancreatic Cancer Stem Cells

2012 ◽  
Vol 142 (5) ◽  
pp. S-50-S-51
Author(s):  
Christina Vorvis ◽  
George A. Poultsides ◽  
Jeffrey A. Norton ◽  
Maria Hatziapostolou ◽  
Dimitrios Iliopoulos
Keyword(s):  
Pancreatic Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Whole Transcriptome ◽  
Pancreatic Cancer Stem Cells

Targeting pancreatic cancer stem cells for cancer therapy

2012 ◽  
Vol 1826 (2) ◽  
pp. 385-399 ◽  
Author(s):  
Jun Xia ◽  
Changjie Chen ◽  
Zhiwen Chen ◽  
Lucio Miele ◽  
Fazlul H. Sarkar ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Stem Cells ◽  
Cancer Therapy ◽  
Cancer Stem Cells ◽  
Pancreatic Cancer Stem Cells

scholarly journals Oncolytic Viruses Effectively Target and Kill Pancreatic Cancer Stem Cells

2011 ◽  
Vol 140 (5) ◽  
pp. S-1000-S-1001
Author(s):  
Joyce Wong ◽  
Allison Schulman ◽  
Arjun Mittra ◽  
Yuman Fong
Keyword(s):  
Pancreatic Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Oncolytic Viruses ◽  
Pancreatic Cancer Stem Cells
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