scholarly journals Hepatocellular carcinoma associated microRNA expression signature: integrated bioinformatics analysis, experimental validation and clinical significance

Oncotarget ◽  
2015 ◽  
Vol 6 (28) ◽  
pp. 25093-25108 ◽  
Author(s):  
Ke-Qing Shi ◽  
Zhuo Lin ◽  
Xiang-Jian Chen ◽  
Mei Song ◽  
Yu-Qun Wang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Clinical Significance ◽  
Experimental Validation ◽  
Bioinformatics Analysis ◽  
Microrna Expression ◽  
Expression Signature

Clinical Significance and Prognostic Value of microRNA Expression Signatures in Hepatocellular Carcinoma

2013 ◽  
Vol 19 (17) ◽  
pp. 4780-4791 ◽  
Author(s):  
Rongrong Wei ◽  
Guo-Liang Huang ◽  
Mei-Yin Zhang ◽  
Bin-Kui Li ◽  
Hui-Zhong Zhang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Clinical Significance ◽  
Prognostic Value ◽  
Microrna Expression

scholarly journals A Seven-microRNA Expression Signature Predicts Survival in Hepatocellular Carcinoma

PLoS ONE ◽  
2015 ◽  
Vol 10 (6) ◽  
pp. e0128628 ◽  
Author(s):  
Jian Zhang ◽  
Charing C. N. Chong ◽  
George G. Chen ◽  
Paul B. S. Lai
Keyword(s):  
Hepatocellular Carcinoma ◽  
Microrna Expression ◽  
Expression Signature

scholarly journals Clinical significance of miR-1180-3p in hepatocellular carcinoma: a study based on bioinformatics analysis and RT-qPCR validation

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Zihan Zhou ◽  
Xianguo Zhou ◽  
Yanji Jiang ◽  
Moqin Qiu ◽  
Xiumei Liang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Clinical Significance ◽  
Bioinformatics Analysis

scholarly journals Integrated bioinformatics analysis of the osteoarthritis‑associated microRNA expression signature

2017 ◽  
Author(s):  
Xi Wang ◽  
Yujie Ning ◽  
Bing Zhou ◽  
Lei Yang ◽  
Yingting Wang ◽  
...  
Keyword(s):  
Bioinformatics Analysis ◽  
Microrna Expression ◽  
Expression Signature

scholarly journals Identification and Validation of New Cancer Stem Cell-Related Genes and Their Regulatory microRNAs in Colorectal Cancerogenesis

Biomedicines ◽  
2021 ◽  
Vol 9 (2) ◽  
pp. 179
Author(s):  
Kristian Urh ◽  
Margareta Žlajpah ◽  
Nina Zidar ◽  
Emanuela Boštjančič
Keyword(s):  
Experimental Validation ◽  
Target Gene ◽  
Bioinformatics Analysis ◽  
Early Carcinoma ◽  
Significant Progress ◽  
Formalin Fixed Paraffin ◽  
Formalin Fixed Paraffin Embedded ◽  
Node Metastases ◽  
Formalin Fixed ◽  
Made In

Significant progress has been made in the last decade in our understanding of the pathogenetic mechanisms of colorectal cancer (CRC). Cancer stem cells (CSC) have gained much attention and are now believed to play a crucial role in the pathogenesis of various cancers, including CRC. In the current study, we validated gene expression of four genes related to CSC, L1TD1, SLITRK6, ST6GALNAC1 and TCEA3, identified in a previous bioinformatics analysis. Using bioinformatics, potential miRNA-target gene correlations were prioritized. In total, 70 formalin-fixed paraffin-embedded biopsy samples from 47 patients with adenoma, adenoma with early carcinoma and CRC without and with lymph node metastases were included. The expression of selected genes and microRNAs (miRNAs) was evaluated using quantitative PCR. Differential expression of all investigated genes and four of six prioritized miRNAs (hsa-miR-199a-3p, hsa-miR-335-5p, hsa-miR-425-5p, hsa-miR-1225-3p, hsa-miR-1233-3p and hsa-miR-1303) was found in at least one group of CRC cancerogenesis. L1TD1, SLITRK6, miR-1233-3p and miR-1225-3p were correlated to the level of malignancy. A negative correlation between miR-199a-3p and its predicted target SLITRK6 was observed, showing potential for further experimental validation in CRC. Our results provide further evidence that CSC-related genes and their regulatory miRNAs are involved in CRC development and progression and suggest that some them, particularly miR-199a-3p and its SLITRK6 target gene, are promising for further validation in CRC.

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