scholarly journals A combination of a ribonucleotide reductase inhibitor and histone deacetylase inhibitors downregulates EGFR and triggers BIM-dependent apoptosis in head and neck cancer

Oncotarget ◽  
2011 ◽  
Vol 3 (1) ◽  
pp. 31-43 ◽  
Author(s):  
Roland H. Stauber ◽  
Shirley K. Knauer ◽  
Negusse Habtemichael ◽  
Carolin Bier ◽  
Britta Unruhe ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Histone Deacetylase ◽  
Neck Cancer ◽  
Ribonucleotide Reductase ◽  
Reductase Inhibitor ◽  
Histone Deacetylase Inhibitors ◽  
Ribonucleotide Reductase Inhibitor

scholarly journals Phase II trial of the histone deacetylase inhibitor romidepsin in patients with recurrent/metastatic head and neck cancer

Oral Oncology ◽  
2012 ◽  
Vol 48 (12) ◽  
pp. 1281-1288 ◽  
Author(s):  
Missak Haigentz ◽  
Mimi Kim ◽  
Catherine Sarta ◽  
Juan Lin ◽  
Roger S. Keresztes ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Histone Deacetylase ◽  
Phase Ii ◽  
Neck Cancer ◽  
Histone Deacetylase Inhibitor ◽  
Phase Ii Trial ◽  
Deacetylase Inhibitor

scholarly journals Inhibition of Histone Deacetylase Impacts Cancer Stem Cells and Induces Epithelial-Mesenchyme Transition of Head and Neck Cancer

PLoS ONE ◽  
2013 ◽  
Vol 8 (3) ◽  
pp. e58672 ◽  
Author(s):  
Fernanda S. Giudice ◽  
Decio S. Pinto ◽  
Jacques E. Nör ◽  
Cristiane H. Squarize ◽  
Rogerio M. Castilho
Keyword(s):  
Stem Cells ◽  
Head And Neck Cancer ◽  
Cancer Stem Cells ◽  
Head And Neck ◽  
Histone Deacetylase ◽  
Neck Cancer

scholarly journals Usefulness of Melatonin and Other Compounds as Antioxidants and Epidrugs in the Treatment of Head and Neck Cancer

Antioxidants ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 35
Author(s):  
Joaquín Guerra ◽  
Jesús Devesa
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Histone Deacetylase Inhibitors ◽  
Organic Production ◽  
Epigenetic Mechanism ◽  
In Vivo Studies ◽  
Epigenetic Alterations ◽  
Cytotoxic Treatment

Along with genetic mutations, aberrant epigenetic alterations are the initiators of head and neck cancer carcinogenesis. Currently, several drugs are being developed to correct these epigenetic alterations, known as epidrugs. Some compounds with an antioxidant effect have been shown to be effective in preventing these malignant lesions and in minimizing the complications derived from cytotoxic treatment. Furthermore, in vitro and in vivo studies show a promising role in the treatment of head and neck squamous cell carcinoma (HNSCC). This is the case of supplements with DNA methylation inhibitory function (DNMTi), such as epigallocatechin gallate, sulforaphane, and folic acid; histone deacetylase inhibitors (HDACi), such as sodium butyrate and melatonin or histone acetyltransferase inhibitors (HATi), such as curcumin. The objective of this review is to describe the role of some antioxidants and their epigenetic mechanism of action, with special emphasis on melatonin and butyric acid given their organic production, in the prevention and treatment of HNSCC.

Nutritional status as a prognostic factor in advanced head and neck cancer

1998 ◽  
Vol 23 (4) ◽  
pp. 376-376
Author(s):  
Quak ◽  
Van Bokhorst ◽  
Klop ◽  
Van Leeuwen ◽  
Snow
Keyword(s):  
Head And Neck Cancer ◽  
Prognostic Factor ◽  
Nutritional Status ◽  
Head And Neck ◽  
Neck Cancer ◽  
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