scholarly journals Nuclear translocation of fibroblast growth factor-2 (FGF2) is regulated by Karyopherin-β2 and Ran GTPase in human glioblastoma cells

Oncotarget ◽  
2015 ◽  
Vol 6 (25) ◽  
pp. 21468-21478 ◽  
Author(s):  
Feng Wang ◽  
Lijun Yang ◽  
Lin Shi ◽  
Qian Li ◽  
Gengshen Zhang ◽  
...  
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Nuclear Translocation ◽  
Fibroblast Growth Factor 2 ◽  
Fibroblast Growth ◽  
Glioblastoma Cells ◽  
Ran Gtpase ◽  
Human Glioblastoma ◽  
Human Glioblastoma Cells

scholarly journals Novel Nuclear Signaling Pathway Mediates Activation of Fibroblast Growth Factor-2 Gene by Type 1 and Type 2 Angiotensin II Receptors

2001 ◽  
Vol 12 (2) ◽  
pp. 449-462 ◽  
Author(s):  
Hu Peng ◽  
John Moffett ◽  
Jason Myers ◽  
Xiaohong Fang ◽  
Ewa K. Stachowiak ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Nuclear Translocation ◽  
Fibroblast Growth Factor 2 ◽  
Fibroblast Growth ◽  
Fgf Receptor ◽  
Responsive Element

In bovine adrenal medullary cells synergistically acting type 1 and type 2 angiotensin II (AII) receptors activate the fibroblast growth factor-2 (FGF-2) gene through a unique AII-responsive promoter element. Both the type 1 and type 2 AII receptors and the downstream cyclic adenosine 1′,3′-monophosphate- and protein kinase C-dependent signaling pathways activate the FGF-2 promoter through a novel signal-transducing mechanism. This mechanism, which we have named integrative nuclear FGF receptor-1 signaling, involves the nuclear translocation of FGF receptor-1 and its subsequent transactivation of the AII-responsive element in the FGF-2 promoter.

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