scholarly journals Phospholipase PLA2G7, associated with aggressive prostate cancer, promotes prostate cancer cell migration and invasion and is inhibited by statins

Oncotarget ◽  
2011 ◽  
Vol 2 (12) ◽  
pp. 1176-1190 ◽  
Author(s):  
Paula Vainio ◽  
Laura Lehtinen ◽  
Tuomas Mirtti ◽  
Mika Hilvo ◽  
Tuulikki Seppänen-Laakso ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Migration ◽  
Cancer Cell ◽  
Prostate Cancer Cell ◽  
Migration And Invasion ◽  
Cancer Cell Migration ◽  
Aggressive Prostate Cancer ◽  
Cell Migration And Invasion

scholarly journals Novel lncRNA LINC00844 Regulates Prostate Cancer Cell Migration and Invasion through AR Signaling

2018 ◽  
Vol 16 (12) ◽  
pp. 1865-1878 ◽  
Author(s):  
Shreyas Lingadahalli ◽  
Sudhir Jadhao ◽  
Ying Ying Sung ◽  
Mi Chen ◽  
Lingling Hu ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Migration ◽  
Cancer Cell ◽  
Prostate Cancer Cell ◽  
Migration And Invasion ◽  
Cancer Cell Migration ◽  
Cell Migration And Invasion

scholarly journals Androgen-regulated microRNA-135a decreases prostate cancer cell migration and invasion through downregulating ROCK1 and ROCK2

Oncogene ◽  
2014 ◽  
Vol 34 (22) ◽  
pp. 2846-2855 ◽  
Author(s):  
A Kroiss ◽  
S Vincent ◽  
M Decaussin-Petrucci ◽  
E Meugnier ◽  
J Viallet ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Migration ◽  
Cancer Cell ◽  
Prostate Cancer Cell ◽  
Migration And Invasion ◽  
Cancer Cell Migration ◽  
Cell Migration And Invasion

scholarly journals Expression and Functional Role of CCR9 in Prostate Cancer Cell Migration and Invasion

2004 ◽  
Vol 10 (24) ◽  
pp. 8743-8750 ◽  
Author(s):  
Shailesh Singh ◽  
Udai P. Singh ◽  
Jonathan K. Stiles ◽  
William E. Grizzle ◽  
James W. Lillard
Keyword(s):  
Prostate Cancer ◽  
Cell Migration ◽  
Cancer Cell ◽  
Functional Role ◽  
Prostate Cancer Cell ◽  
Migration And Invasion ◽  
Cancer Cell Migration ◽  
Cell Migration And Invasion

Tissue kallikrein promotes prostate cancer cell migration and invasion via a protease-activated receptor-1-dependent signaling pathway

2010 ◽  
Vol 391 (7) ◽  
Author(s):  
Lin Gao ◽  
Robert S. Smith ◽  
Li-Mei Chen ◽  
Karl X. Chai ◽  
Lee Chao ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Migration ◽  
Cancer Cell ◽  
Prostate Cancer Cell ◽  
Du145 Cell ◽  
Migration And Invasion ◽  
Tissue Kallikrein ◽  
Cancer Cell Migration ◽  
Cell Migration And Invasion ◽  
Protease Activated Receptor 1

Abstract We recently demonstrated that tissue kallikrein (TK) promotes keratinocyte migration through activation of protease-activated receptor-1 (PAR1) and transactivation of the epi-dermal growth factor receptor (EGFR). In this study, we investigated the potential role of PAR1 in mediating the effect of TK on cancer cell migration, invasion and proliferation. Our results show that TK promotes DU145 prostate cancer cell migration in a concentration-dependent manner, but has no effect on A549 lung cancer cells. Active TK markedly increases DU145 cell migration and invasion, which are blocked by aprotinin but minimally affected by icatibant; kinin treatment has little effect. TK-induced cell migration and invasion are abolished by inhibition of PAR1 using a pharmacological inhibitor or RNA interference. The effect of TK on cell migration and invasion are also blocked by inhibitors of protein kinase C, c-Src, matrix metalloproteinase, EGFR and extracellular signal-regulated kinase (ERK). Moreover, TK stimulates ERK phosphorylation, which is inhibited by an EGFR antagonist. Additionally, TK but not kinin stimulates DU145 cell proliferation through activation of the kinin B2 receptor, but not PAR1 and EGFR. These results indicate differential signaling pathways mediated by TK in promoting prostate cancer cell migration and invasion via PAR1 activation, and proliferation via kinin B2 receptor stimulation.

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