scholarly journals CIP2A is a candidate therapeutic target in clinically challenging prostate cancer cell populations

Oncotarget ◽  
2015 ◽  
Vol 6 (23) ◽  
pp. 19661-19670 ◽  
Author(s):  
Anchit Khanna ◽  
Jayant K. Rane ◽  
Kati K. Kivinummi ◽  
Alfonso Urbanucci ◽  
Merja A. Helenius ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cell ◽  
Therapeutic Target ◽  
Prostate Cancer Cell ◽  
Cell Populations

scholarly journals CD44 + cells determine fenofibrate‐induced microevolution of drug‐resistance in prostate cancer cell populations

Stem Cells ◽  
2020 ◽  
Vol 38 (12) ◽  
pp. 1544-1556 ◽  
Author(s):  
Tomasz Wróbel ◽  
Marcin Luty ◽  
Jessica Catapano ◽  
Elżbieta Karnas ◽  
Małgorzata Szczygieł ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Drug Resistance ◽  
Cancer Cell ◽  
Prostate Cancer Cell ◽  
Cell Populations

scholarly journals HNRNPM controls circRNA biogenesis and splicing fidelity to sustain prostate cancer cell fitness

2020 ◽  
Author(s):  
Jessica SY Ho ◽  
Diana Low ◽  
Megan Schwarz ◽  
Danny Incarnato ◽  
Florence Gay ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Growth ◽  
Cancer Cell ◽  
Therapeutic Target ◽  
Prostate Cancer Cell ◽  
Sequencing Data ◽  
Potential Therapeutic Target ◽  
Splicing Machinery

ABSTRACTCancer cells are differentially dependent on the splicing machinery compared to normal untransformed cells. The splicing machinery thus represents a potential therapeutic target in cancer. To identify splicing factors important for prostate cancer cell (PCa) cell growth, we performed a parallel pooled shRNA screen on in vitro passaged cells and in vivo xenografted PCa tumor lines. Our screen revealed HNRNPM as a potential regulator of PCa cell growth. RNA- and eCLIP-sequencing data suggest that HNRNPM is bound to transcripts of key homeostatic genes and that loss of HNRNPM binding in a subset of these genes results in aberrant exon inclusion and exon back-splicing events in target transcripts. In both linear and circular mis-spliced transcripts, HNRNPM appears to preferentially bind to GU-rich elements in long flanking proximal introns. Mimicry of HNRNPM dependent linear splicing events using splice-switching antisense oligonucleotides (SSOs) was sufficient to inhibit cell growth in HNRNPM expressing cells. This suggests that prostate cancer cell dependence on HNRNPM is likely a result of mis-splicing of key homeostatic coding and non-coding genes. Taken together, our data reveal a role for HNRNPM in supporting prostate cancer cell fitness, and also as a potential therapeutic target in PCa.

664: CXCL12/CXCR4 Trans-Activation of HER2 in Lipid Rafts of Prostate Cancer Cell Membranes Promotes Bone Metastasis

2007 ◽  
Vol 177 (4S) ◽  
pp. 223-223
Author(s):  
Sreenivasa R. Chinni ◽  
Hamilto Yamamoto ◽  
Zhong Dong ◽  
Aaron Sabbota ◽  
Sanaa Nabha ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Bone Metastasis ◽  
Lipid Rafts ◽  
Cancer Cell ◽  
Cell Membranes ◽  
Prostate Cancer Cell

571: Importance of the Intracrine Metabolism of Adrenal Androgens in Androgen Dependent Prostate Cancer Cell Activity

2005 ◽  
Vol 173 (4S) ◽  
pp. 156-156
Author(s):  
Kazuya Suzuki ◽  
Tsutomu Nishiyama ◽  
Noboru Hara ◽  
Vladimir Bilim ◽  
Kazutoshi Yamana ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cell ◽  
Prostate Cancer Cell ◽  
Cell Activity ◽  
Adrenal Androgens

797: Noggin Blocks the Osteoinductive Properties of Human Prostate Cancer Cell Lines

2006 ◽  
Vol 175 (4S) ◽  
pp. 258-258
Author(s):  
Ruth Schwaninger ◽  
Cyrill A. Rentsch ◽  
Antoinette Wetterwald ◽  
Irena Klima ◽  
Gabri Van der Pluijm ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Prostate Cancer Cell ◽  
Cancer Cell Lines ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Human Prostate Cancer Cell ◽  
Prostate Cancer Cell Lines

794: Valproic Acid Inhibits Prostate Cancer Cell Growth in Vitro and in Vivo

2006 ◽  
Vol 175 (4S) ◽  
pp. 257-257
Author(s):  
Jennifer Sung ◽  
Qinghua Xia ◽  
Wasim Chowdhury ◽  
Shabana Shabbeer ◽  
Michael Carducci ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Valproic Acid ◽  
Cell Growth ◽  
Cancer Cell ◽  
Prostate Cancer Cell ◽  
Cancer Cell Growth
Sign in / Sign up

Export Citation Format

Share Document