scholarly journals MET receptor is a potential therapeutic target in high grade cervical cancer

Oncotarget ◽  
2015 ◽  
Vol 6 (12) ◽  
pp. 10086-10101 ◽  
Author(s):  
Katarzyna Miekus ◽  
Marta Pawlowska ◽  
Małgorzata Sekuła ◽  
Grazyna Drabik ◽  
Zbigniew Madeja ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Therapeutic Target ◽  
High Grade ◽  
Met Receptor ◽  
Potential Therapeutic Target

scholarly journals Maternal embryonic leucine zipper kinase: A novel biomarker and a potential therapeutic target of cervical cancer

2018 ◽  
Vol 7 (11) ◽  
pp. 5665-5678 ◽  
Author(s):  
Juan Wang ◽  
Yamei Wang ◽  
Fangrong Shen ◽  
Yanting Xu ◽  
Yinghui Zhang ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Therapeutic Target ◽  
Leucine Zipper ◽  
Potential Therapeutic Target ◽  
Kinase A

Cyclin E as a potential therapeutic target in high grade serous ovarian cancer

2016 ◽  
Vol 143 (1) ◽  
pp. 152-158 ◽  
Author(s):  
J. Kanska ◽  
M. Zakhour ◽  
B. Taylor-Harding ◽  
B.Y. Karlan ◽  
W.R. Wiedemeyer
Keyword(s):  
Ovarian Cancer ◽  
Therapeutic Target ◽  
Cyclin E ◽  
High Grade ◽  
Serous Ovarian Cancer ◽  
Potential Therapeutic Target

scholarly journals Identification of FGFR4 as a Potential Therapeutic Target for Advanced-Stage, High-Grade Serous Ovarian Cancer

2013 ◽  
Vol 19 (4) ◽  
pp. 809-820 ◽  
Author(s):  
Tarrik M. Zaid ◽  
Tsz-Lun Yeung ◽  
Melissa S. Thompson ◽  
Cecilia S. Leung ◽  
Tom Harding ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Therapeutic Target ◽  
High Grade ◽  
Advanced Stage ◽  
Serous Ovarian Cancer ◽  
Potential Therapeutic Target

scholarly journals Sulfiredoxin as a Potential Therapeutic Target for Advanced and Metastatic Prostate Cancer

2020 ◽  
Vol 2020 ◽  
pp. 1-12 ◽  
Author(s):  
Caroline N. Barquilha ◽  
Nilton J. Santos ◽  
Caio C. D. Monção ◽  
Isabela C. Barbosa ◽  
Flávio O. Lima ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Lines ◽  
Therapeutic Target ◽  
Genetically Engineered ◽  
High Grade ◽  
Sequencing Data ◽  
Potential Therapeutic Target ◽  
Prostate Tumors ◽  
Mouse Prostate

The incidence of prostate cancer (PCa) is increasing, and it is currently the second most frequent cause of death by cancer in men. Despite advancements in cancer therapies, new therapeutic approaches are still needed for treatment-refractory advanced metastatic PCa. Cross-species analysis presents a robust strategy for the discovery of new potential therapeutic targets. This strategy involves the integration of genomic data from genetically engineered mouse models (GEMMs) and human PCa datasets. Considering the role of antioxidant pathways in tumor initiation and progression, we searched oxidative stress-related genes for a potential therapeutic target for PCa. First, we analyzed RNA-sequencing data from Pb-Cre4; Ptenf/f mice and discovered an increase in sulfiredoxin (Srxn1) mRNA expression in high-grade prostatic intraepithelial neoplasia (PIN), well-differentiated adenocarcinoma (medium-stage tumors), and poor-differentiated adenocarcinoma (advanced-stage prostate tumors). The increase of SRXN1 protein expression was confirmed by immunohistochemistry in mouse prostate tumor paraffin samples. Analyses of human databases and prostate tissue microarrays demonstrated that SRXN1 is overexpressed in a subset of high-grade prostate tumors and correlates with aggressive PCa with worse prognosis and decreased survival. Analyses in vitro showed that SRXN1 expression is also higher in most PCa cell lines compared to normal cell lines. Furthermore, siRNA-mediated downregulation of SRXN1 led to decreased viability of PCa cells LNCaP. In conclusion, we identified the antioxidant enzyme SRXN1 as a potential therapeutic target for PCa. Our results suggest that the use of specific SRXN1 inhibitors may be an effective strategy for the adjuvant treatment of castration-resistant PCa with SRXN1 overexpression.

scholarly journals HER2 expression in cervical cancer as a potential therapeutic target

BMC Cancer ◽  
2004 ◽  
Vol 4 (1) ◽  
Author(s):  
Alma Chavez-Blanco ◽  
Victor Perez-Sanchez ◽  
Aurora Gonzalez-Fierro ◽  
Teresa Vela-Chavez ◽  
Myrna Candelaria ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Therapeutic Target ◽  
Her2 Expression ◽  
Potential Therapeutic Target

scholarly journals Multiomic analysis identifies CPT1A as a potential therapeutic target in platinum-refractory, high-grade serous ovarian cancer

2021 ◽  
Vol 2 (12) ◽  
pp. 100471
Author(s):  
Dongqing Huang ◽  
Shrabanti Chowdhury ◽  
Hong Wang ◽  
Sara R. Savage ◽  
Richard G. Ivey ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Therapeutic Target ◽  
High Grade ◽  
Serous Ovarian Cancer ◽  
Potential Therapeutic Target ◽  
Platinum Refractory
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