scholarly journals mTOR kinase inhibitors synergize with histone deacetylase inhibitors to kill B-cell acute lymphoblastic leukemia cells

Oncotarget ◽  
2014 ◽  
Vol 6 (4) ◽  
pp. 2088-2100 ◽  
Author(s):  
Brandon R. Beagle ◽  
Duc M. Nguyen ◽  
Sharmila Mallya ◽  
Sarah S. Tang ◽  
Mengrou Lu ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
B Cell ◽  
Histone Deacetylase ◽  
Histone Deacetylase Inhibitors ◽  
Kinase Inhibitors ◽  
Lymphoblastic Leukemia ◽  
Leukemia Cells ◽  
Mtor Kinase ◽  
Cell Acute Lymphoblastic Leukemia

scholarly journals Lymphoblast purine pathway enzymes in B-cell acute lymphoblastic leukemia

Blood ◽  
1981 ◽  
Vol 58 (2) ◽  
pp. 330-332 ◽  
Author(s):  
GH Reaman ◽  
J Blatt ◽  
DG Poplack
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
B Cell ◽  
Metabolic Pathway ◽  
Purine Nucleoside Phosphorylase ◽  
Lymphoblastic Leukemia ◽  
Leukemia Cells ◽  
Malignant Cells ◽  
B Cell Malignancies ◽  
Cell Acute Lymphoblastic Leukemia ◽  
Purine Pathway

Abstract Activities of enzymes of the purine metabolic pathway, adenosine deaminase (ADA), purine nucleoside phosphorylase (PNP), and 5′- nucleotidase (5′-N), were investigated in the lymphoblasts of a patient with B-cell acute lymphoblastic leukemia. These lymphoblasts exhibited increased ADA activity and diminished activities of both PNP and 5′N' as compared to normal lymphocytes as well as non-T, non-B leukemia cells. This enzymatic pattern is identical to that which has been described in T-cell leukemic lymphoblasts and differs from that which has been observed in the malignant cells of undifferentiated B-cell lymphomas. These data suggest that there is biochemical heterogeneity within the spectrum of B-cell malignancies. Furthermore, inhibitors of ADA may be of use in those B-cell lymphoid neoplasms that exhibit increased ADA activity.

scholarly journals Reprogramming of B cell acute lymphoblastic leukemia cells: Do we need to shoot a moving target?

2015 ◽  
Vol 112 (27) ◽  
pp. E3455-E3455 ◽  
Author(s):  
Karel Fišer ◽  
Lucie Slámová ◽  
Jean-Pierre Bourquin ◽  
Jan Trka ◽  
Jan Starý ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
B Cell ◽  
Lymphoblastic Leukemia ◽  
Leukemia Cells ◽  
Moving Target ◽  
Cell Acute Lymphoblastic Leukemia

scholarly journals TAL1/SCL is downregulated upon histone deacetylase inhibition in T-cell acute lymphoblastic leukemia cells

Leukemia ◽  
2011 ◽  
Vol 25 (10) ◽  
pp. 1578-1586 ◽  
Author(s):  
B A Cardoso ◽  
S F de Almeida ◽  
A B A Laranjeira ◽  
M Carmo-Fonseca ◽  
J A Yunes ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
T Cell ◽  
Histone Deacetylase ◽  
Lymphoblastic Leukemia ◽  
Leukemia Cells ◽  
Histone Deacetylase Inhibition ◽  
Cell Acute Lymphoblastic Leukemia

scholarly journals Lymphoblast purine pathway enzymes in B-cell acute lymphoblastic leukemia

Blood ◽  
1981 ◽  
Vol 58 (2) ◽  
pp. 330-332
Author(s):  
GH Reaman ◽  
J Blatt ◽  
DG Poplack
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
B Cell ◽  
Metabolic Pathway ◽  
Purine Nucleoside Phosphorylase ◽  
Lymphoblastic Leukemia ◽  
Leukemia Cells ◽  
Malignant Cells ◽  
B Cell Malignancies ◽  
Cell Acute Lymphoblastic Leukemia ◽  
Purine Pathway

Activities of enzymes of the purine metabolic pathway, adenosine deaminase (ADA), purine nucleoside phosphorylase (PNP), and 5′- nucleotidase (5′-N), were investigated in the lymphoblasts of a patient with B-cell acute lymphoblastic leukemia. These lymphoblasts exhibited increased ADA activity and diminished activities of both PNP and 5′N' as compared to normal lymphocytes as well as non-T, non-B leukemia cells. This enzymatic pattern is identical to that which has been described in T-cell leukemic lymphoblasts and differs from that which has been observed in the malignant cells of undifferentiated B-cell lymphomas. These data suggest that there is biochemical heterogeneity within the spectrum of B-cell malignancies. Furthermore, inhibitors of ADA may be of use in those B-cell lymphoid neoplasms that exhibit increased ADA activity.

Targeting non-oncogene ROS pathway by alantolactone in B cell acute lymphoblastic leukemia cells

Life Sciences ◽  
2019 ◽  
Vol 227 ◽  
pp. 153-165 ◽  
Author(s):  
Xiaoguang Xu ◽  
Lei Huang ◽  
Zilu Zhang ◽  
Jia Tong ◽  
Jianqing Mi ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
B Cell ◽  
Lymphoblastic Leukemia ◽  
Leukemia Cells ◽  
Cell Acute Lymphoblastic Leukemia

Troglitazone Inhibits Cell Growth and Induces Apoptosis of B-Cell Acute Lymphoblastic Leukemia Cells with t(14;18)

2006 ◽  
Vol 116 (1) ◽  
pp. 30-40 ◽  
Author(s):  
M. Takenokuchi ◽  
K. Saigo ◽  
Y. Nakamachi ◽  
S. Kawano ◽  
M. Hashimoto ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Cell Growth ◽  
B Cell ◽  
Lymphoblastic Leukemia ◽  
Leukemia Cells ◽  
Cell Acute Lymphoblastic Leukemia
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