scholarly journals Poor survival is associated with the methylated degree of zinc-finger protein 545 (ZNF545) DNA promoter in gastric cancer

Oncotarget ◽  
2015 ◽  
Vol 6 (6) ◽  
pp. 4482-4495 ◽  
Author(s):  
Jingyu Deng ◽  
Han Liang ◽  
Guoguang Ying ◽  
Qiuping Dong ◽  
Rupeng Zhang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Zinc Finger ◽  
Zinc Finger Protein ◽  
Poor Survival ◽  
Finger Protein

Zinc-finger protein 545 is a novel tumour suppressor that acts by inhibiting ribosomal RNA transcription in gastric cancer

Gut ◽  
2012 ◽  
Vol 62 (6) ◽  
pp. 833-841 ◽  
Author(s):  
Shiyan Wang ◽  
Yingduan Cheng ◽  
Wan Du ◽  
Leina Lu ◽  
Liang Zhou ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Zinc Finger ◽  
Ribosomal Rna ◽  
Zinc Finger Protein ◽  
Tumour Suppressor ◽  
Rna Transcription ◽  
Finger Protein

Zinc-finger protein 331, a novel putative tumor suppressor, suppresses growth and invasiveness of gastric cancer

Oncogene ◽  
2012 ◽  
Vol 32 (3) ◽  
pp. 307-317 ◽  
Author(s):  
J Yu ◽  
Q Y Liang ◽  
J Wang ◽  
Y Cheng ◽  
S Wang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Tumor Suppressor ◽  
Zinc Finger ◽  
Zinc Finger Protein ◽  
Finger Protein ◽  
Putative Tumor Suppressor

Zinc-Finger Protein 471 Functions as a Tumor Suppressor in Gastric Cancer through Transcriptionally Repressing TFAP2A and PLS3

2017 ◽  
Vol 152 (5) ◽  
pp. S801-S802
Author(s):  
Lei Cao ◽  
Shiyan Wang ◽  
Yanquan Zhang ◽  
Ka Chun Wong ◽  
Daniel Nakatsu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Tumor Suppressor ◽  
Zinc Finger ◽  
Zinc Finger Protein ◽  
Finger Protein

scholarly journals Zinc Finger Protein 331, a Novel Putative Tumor Suppressor, Suppresses Growth and Invasiveness of Gastric Cancer Cells

2011 ◽  
Vol 140 (5) ◽  
pp. S-818-S-819
Author(s):  
Jun Yu ◽  
Jia Wang ◽  
Qiaoyi Liang ◽  
Kin-Fai Cheung ◽  
Shiyan Wang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Tumor Suppressor ◽  
Cancer Cells ◽  
Zinc Finger ◽  
Zinc Finger Protein ◽  
Gastric Cancer Cells ◽  
Finger Protein ◽  
Putative Tumor Suppressor

scholarly journals Zinc Finger Protein 521, Negatively Regulated by MicroRNA-204-5p, Promotes Proliferation, Motility and Invasion of Gastric Cancer Cells

2019 ◽  
Vol 18 ◽  
pp. 153303381987478 ◽  
Author(s):  
Chen Huan ◽  
Cai Xiaoxu ◽  
Ren Xifang
Keyword(s):  
Gastric Cancer ◽  
Western Blot ◽  
Cancer Cells ◽  
Zinc Finger ◽  
Zinc Finger Protein ◽  
Cell Counting ◽  
Luciferase Reporter ◽  
Migration And Invasion ◽  
Gastric Cancer Cells ◽  
Finger Protein

Objective: This study aims to investigate the expression, role, and detailed mechanism of microRNA-204-5p and zinc finger protein 521 in gastric cancer. Methods: Immunohistochemistry was adopted to detect the expressions of zinc finger protein 521 in 82 cases of gastric cancer tissues. Western blot was used to detect the expressions of zinc finger protein 521 in gastric cancer cells and adjacent cells. Moreover, the correlation between zinc finger protein 521 and the prognosis of patients were also evaluated. Cell Counting Kit 8 assay and colony formation assay were performed to figure out the impact of zinc finger protein 521 on the proliferation of gastric cancer cells. By conducting flow cytometry, the effect of zinc finger protein 521 on the apoptosis of gastric cancer cells was determined. The scratch wound healing assay and transwell invasion assay were carried out to determine the effect of zinc finger protein 521 on regulating the motility and invasion of gastric cancer cells. Ultimately, the targeting relationship and interaction between microRNA-204-5p and zinc finger protein 521 were verified by real-time polymerase chain reaction, Western blot, and dual luciferase reporter gene assay. Results: Compared with adjacent cells, zinc finger protein 521 was highly expressed in gastric cancer cells, which was related to TNM stage ( P = .0388), tumor size ( P = .0168), and local lymph node metastasis ( P = .0024). Overexpressed zinc finger protein 521 can promote the proliferation, migration, and invasion of gastric cancer cells and inhibit the apoptosis. Zinc finger protein 521 is a target gene of microRNA-106-5p, and there was a negative correlation between the expression of zinc finger protein 521 and microRNA-204-5p. Conclusion: Zinc finger protein 521 can arrest the apoptosis and enhance the proliferation, migration, and invasion of gastric cancer cells via regulating microRNA-204-5p. Our study may provide novel clues for the treatment of patients with gastric cancer.

56 Zinc Finger Protein 545 is a Functional Tumor Suppressor Through Inhibiting Ribosomal RNA Transcription in Gastric Cancer

2012 ◽  
Vol 142 (5) ◽  
pp. S-15
Author(s):  
Shiyan Wang ◽  
Wan Du ◽  
Xiaoxing Li ◽  
Qian Tao ◽  
Joseph J. Sung ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Tumor Suppressor ◽  
Zinc Finger ◽  
Ribosomal Rna ◽  
Zinc Finger Protein ◽  
Rna Transcription ◽  
Finger Protein
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