scholarly journals Xenotropic murine leukemia virus-related virus (XMRV) in prostate cancer cells likely represents a laboratory artifact

Oncotarget ◽  
2011 ◽  
Vol 2 (5) ◽  
pp. 358-362 ◽  
Author(s):  
Jiawen Yang ◽  
Partho Battacharya ◽  
Ruchi Singhal ◽  
Eugene S. Kandel
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Murine Leukemia Virus ◽  
Leukemia Virus ◽  
Prostate Cancer Cells ◽  
Xenotropic Murine Leukemia ◽  
Related Virus ◽  
Murine Leukemia

scholarly journals Downregulation of APOBEC3G by xenotropic murine leukemia-virus related virus (XMRV) in prostate cancer cells

2011 ◽  
Vol 8 (1) ◽  
pp. 531 ◽  
Author(s):  
Abhinav Dey ◽  
Chinmay Mantri ◽  
Jui Pandhare-Dash ◽  
Bindong Liu ◽  
Siddharth Pratap ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Murine Leukemia Virus ◽  
Leukemia Virus ◽  
Prostate Cancer Cells ◽  
Xenotropic Murine Leukemia ◽  
Related Virus ◽  
Murine Leukemia

scholarly journals Lack of evidence for xenotropic murine leukemia virus-related virus(XMRV) in German prostate cancer patients

Retrovirology ◽  
2009 ◽  
Vol 6 (1) ◽  
pp. 92 ◽  
Author(s):  
Oliver Hohn ◽  
Hans Krause ◽  
Pia Barbarotto ◽  
Lars Niederstadt ◽  
Nadine Beimforde ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Patients ◽  
Murine Leukemia Virus ◽  
Leukemia Virus ◽  
Xenotropic Murine Leukemia ◽  
Related Virus ◽  
Murine Leukemia

scholarly journals Androgen Stimulates Transcription and Replication of Xenotropic Murine Leukemia Virus-Related Virus

2009 ◽  
Vol 84 (3) ◽  
pp. 1648-1651 ◽  
Author(s):  
Beihua Dong ◽  
Robert H. Silverman
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Murine Leukemia Virus ◽  
Leukemia Virus ◽  
Xenotropic Murine Leukemia ◽  
Related Virus ◽  
Cellular Genes ◽  
Glucocorticoid Response ◽  
Murine Leukemia ◽  
Transcription And Replication

ABSTRACT Xenotropic murine leukemia virus-related virus (XMRV) is a gammaretrovirus originally identified in a subset of prostate cancer patients. Because androgens stimulate prostate tumors and some retroviruses, we investigated the effects of dihydrotestosterone (DHT) on XMRV transcription and replication. Transcription from the XMRV U3 region was stimulated up to 2-fold by DHT, but only in cells containing a functional androgen receptor. Mutations in the glucocorticoid response element (GRE) of XMRV impaired basal transcription and androgen responsiveness. Furthermore, DHT stimulated XMRV replication 3-fold, whereas androgen inhibitors (casodex and flutamide) suppressed viral growth up to 3-fold. Findings suggest that integration of the XMRV long terminal repeat (LTR) into host DNA could impart androgen stimulation on cellular genes.

scholarly journals Xenotropic Murine Leukemia Virus-Related Virus (XMRV) and the Safety of the Blood Supply

2016 ◽  
Vol 29 (4) ◽  
pp. 749-757 ◽  
Author(s):  
Andrew D. Johnson ◽  
Claudia S. Cohn
Keyword(s):  
Prostate Cancer ◽  
Murine Leukemia Virus ◽  
Leukemia Virus ◽  
Laboratory Mouse ◽  
Emerging Infectious Diseases ◽  
Chronic Fatigue ◽  
Initial Finding ◽  
Xenotropic Murine Leukemia ◽  
Related Virus ◽  
Murine Leukemia

SUMMARYIn 2006, a new virus, xenotropic murine leukemia virus-related virus (XMRV), was discovered in a cohort of U.S. men with prostate cancer. Soon after this initial finding, XMRV was also detected in samples from patients with chronic fatigue syndrome (CFS). The blood community, which is highly sensitive to the threat of emerging infectious diseases since the HIV/AIDS crisis, recommended indefinite deferral of all blood donors with a history of CFS. As XMRV research progressed, conflicting results emerged regarding the importance of this virus in the pathophysiology of prostate cancer and/or CFS. Molecular biologists traced the development of XMRV to a recombination event in a laboratory mouse that likely occurred circa 1993. The virus was propagated via cell lines derived from a tumor present in this mouse and spread through contamination of laboratory samples. Well-controlled experiments showed that detection of XMRV was due to contaminated samples and was not a marker of or a causal factor in prostate cancer or CFS. This paper traces the development of XMRV in the prostate and CFS scientific communities and explores the effect it had on the blood community.

scholarly journals Xenotropic Murine Leukemia Virus-Related Virus and RNase L R462Q Variants in Iranian Patients With Sporadic Prostate Cancer

2015 ◽  
Vol 17 (12) ◽  
Author(s):  
Farhad Babaei ◽  
Ali Ahmadi ◽  
Farhad Rezaei ◽  
Somayeh Jalilvand ◽  
Nastaran Ghavami ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Murine Leukemia Virus ◽  
Leukemia Virus ◽  
Rnase L ◽  
Xenotropic Murine Leukemia ◽  
Related Virus ◽  
Iranian Patients ◽  
Murine Leukemia

scholarly journals Fibrils of Prostatic Acid Phosphatase Fragments Boost Infections with XMRV (Xenotropic Murine Leukemia Virus-Related Virus), a Human Retrovirus Associated with Prostate Cancer

2009 ◽  
Vol 83 (14) ◽  
pp. 6995-7003 ◽  
Author(s):  
Seunghee Hong ◽  
Eric A. Klein ◽  
Jaydip Das Gupta ◽  
Kirsten Hanke ◽  
Christopher J. Weight ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Acid Phosphatase ◽  
Murine Leukemia Virus ◽  
Leukemia Virus ◽  
Prostatic Acid Phosphatase ◽  
Viral Attachment ◽  
Xenotropic Murine Leukemia ◽  
Related Virus ◽  
Cancer Tissues ◽  
Murine Leukemia

ABSTRACT The xenotropic murine leukemia virus-related virus (XMRV) has recently been detected in prostate cancer tissues and may play a role in tumorigenesis. It is currently unclear how this virus is transmitted and which factors promote its spread in the prostate. We show that amyloidogenic fragments known as semen-derived enhancer of virus infection (SEVI) originating from prostatic acid phosphatase greatly increase XMRV infections of primary prostatic epithelial and stromal cells. Hybrid simian/human immunodeficiency chimeric virus particles pseudotyped with XMRV envelope protein were used to demonstrate that the enhancing effect of SEVI, or of human semen itself, was at the level of viral attachment and entry. SEVI enhanced XMRV infectivity but did not bypass the requirement for the xenotropic and polytropic retrovirus receptor 1. Furthermore, XMRV RNA was detected in prostatic secretions of some men with prostate cancer. The fact that the precursor of SEVI is produced in abundance by the prostate indicates that XMRV replication occurs in an environment that provides a natural enhancer of viral infection, and this may play a role in the spread of this virus in the human population.

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