scholarly journals Down regulation of lactate dehydrogenase initiates apoptosis in HeLa and MCF-7 cancer cells through increased voltage-dependent anion channel protein and inhibition of BCL2

Oncotarget ◽  
2021 ◽  
Vol 12 (9) ◽  
pp. 923-935
Author(s):  
Suhail Al-Salam ◽  
Karthishwaran Kandhan ◽  
Manjusha Sudhadevi
Keyword(s):  
Lactate Dehydrogenase ◽  
Cancer Cells ◽  
Anion Channel ◽  
Voltage Dependent Anion Channel ◽  
Down Regulation ◽  
Channel Protein ◽  
Voltage Dependent ◽  
Mcf 7

A comparative study of the porin genes encoding VDAC, a voltage-dependent anion channel protein, in Anopheles gambiae and Drosophila melanogaster

Gene ◽  
2003 ◽  
Vol 317 ◽  
pp. 111-115 ◽  
Author(s):  
Marco Sardiello ◽  
Gaetano Tripoli ◽  
Marta Oliva ◽  
Federica Santolamazza ◽  
Roberta Moschetti ◽  
...  
Keyword(s):  
Drosophila Melanogaster ◽  
Comparative Study ◽  
Anopheles Gambiae ◽  
Anion Channel ◽  
Voltage Dependent Anion Channel ◽  
Channel Protein ◽  
Voltage Dependent ◽  
Genes Encoding

Proteomic approach to the identification of voltage-dependent anion channel protein isoforms in guinea pig brain synaptosomes

PROTEOMICS ◽  
2004 ◽  
Vol 4 (5) ◽  
pp. 1335-1340 ◽  
Author(s):  
Sabrina Liberatori ◽  
Benito Canas ◽  
Chiara Tani ◽  
Luca Bini ◽  
Giuseppe Buonocore ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Anion Channel ◽  
Protein Isoforms ◽  
Voltage Dependent Anion Channel ◽  
Channel Protein ◽  
Pig Brain ◽  
Proteomic Approach ◽  
Brain Synaptosomes ◽  
Voltage Dependent ◽  
Guinea Pig Brain

Effects of a mutation in theDrosophila porin gene encoding mitochondrial voltage-dependent anion channel protein on phototransduction

2007 ◽  
Vol 67 (11) ◽  
pp. 1533-1545 ◽  
Author(s):  
Sunji Lee ◽  
Hung-Tat Leung ◽  
Eunju Kim ◽  
Jeyoun Jang ◽  
Eunsung Lee ◽  
...  
Keyword(s):  
Anion Channel ◽  
Voltage Dependent Anion Channel ◽  
Gene Encoding ◽  
Channel Protein ◽  
Voltage Dependent

scholarly journals Voltage-Dependent Anion Channel Protein 2 (VDAC2) and Receptor of Activated Protein C Kinase 1 (RACK1) Act as Functional Receptors for Lymphocystis Disease Virus Infection

2019 ◽  
Vol 93 (12) ◽  
Author(s):  
Ying Zhong ◽  
Xiaoqian Tang ◽  
Xiuzhen Sheng ◽  
Jing Xing ◽  
Wenbin Zhan
Keyword(s):  
Disease Virus ◽  
Protein C ◽  
Polyclonal Antibodies ◽  
Activated Protein C ◽  
Anion Channel ◽  
Voltage Dependent Anion Channel ◽  
Lymphocystis Disease Virus ◽  
Channel Protein ◽  
Lymphocystis Disease ◽  
Voltage Dependent

ABSTRACTIn previous research, a 27.8-kDa protein in flounderParalichthys olivaceusgill (FG) cells was identified as a putative cellular receptor (27.8R), which mediated lymphocystis disease virus (LCDV) infection via interaction with a 32-kDa viral attachment protein (VAP) of LCDV, and monoclonal antibodies (MAbs) against 27.8R and 32-kDa VAP were developed. In this study, the 27.8R was identified as voltage-dependent anion channel protein 2 (VDAC2) and receptor of activated protein C kinase 1 (RACK1) of flounder. Recombinant VDAC2 (rVDAC2) and RACK1 (rRACK1) were obtained by prokaryotic expression, and rabbit anti-VDAC2/RACK1 polyclonal antibodies were prepared. The rVDAC2, rRACK1, and 27.8-kDa proteins in FG cells were recognized by anti-27.8R MAbs and anti-VDAC2/RACK1 polyclonal antibodies simultaneously. Preincubation of FG cells with anti-VDAC2/RACK1 polyclonal antibodies significantly decreased the percentages of LCDV-infected cells and LCDV copy numbers, blocked virus infection, and delayed the development of cytopathic effect. The mRNA expressions of VDAC2 and RACK1 in FG cells were upregulated to maximum levels 12 h and 48 h after LCDV infection, respectively. VDAC2/RACK1 knockdown through short interfering RNA (siRNA) significantly reduced VDAC2/RACK1 expression and LCDV copy numbers in FG cells compared with negative controls, while VDAC2/RACK1 expression on LCDV-nonpermissive epithelial papillosum cells (EPCs) conferred susceptibility to LCDV infection, indicating the VDAC2 and RACK1 were sufficient to allow LCDV entry and infection. All these results collectively showed that VDAC2 and RACK1 function as receptors for LCDV entry and infection.IMPORTANCELymphocystis disease virus (LCDV) is the causative agent of lymphocystis disease in fish, which has caused huge economic losses to the aquaculture industry worldwide, but the molecular mechanism underlying the LCDV-host interaction remains unclear. Here, the 27.8-kDa putative cellular receptor for LCDV was identified as voltage-dependent anion channel protein 2 (VDAC2) and receptor of activated protein C kinase 1 (RACK1), and our results revealed that VDAC2 and RACK1 expression was sufficient to allow LCDV entry and that they are functional receptors that initiate LCDV infection for the first time, which leads to a better understanding of the molecular mechanism underlying LCDV infection and virus-host interactions.

scholarly journals Effects of a mutation in theDrosophila porin gene encoding mitochondrial voltage-dependent anion channel protein on phototransduction

2007 ◽  
Vol 67 (12) ◽  
pp. 1686-1686
Author(s):  
Sunji Lee ◽  
Hung-Tat Leung ◽  
Eunju Kim ◽  
Jeyoun Jang ◽  
Eunsung Lee ◽  
...  
Keyword(s):  
Anion Channel ◽  
Voltage Dependent Anion Channel ◽  
Gene Encoding ◽  
Channel Protein ◽  
Voltage Dependent
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