scholarly journals Quantitative ultrasound radiomics using texture derivatives in prediction of treatment response to neo-adjuvant chemotherapy for locally advanced breast cancer

Oncotarget ◽  
2020 ◽  
Vol 11 (42) ◽  
pp. 3782-3792
Author(s):  
Archya Dasgupta ◽  
Stephen Brade ◽  
Lakshmanan Sannachi ◽  
Karina Quiaoit ◽  
Kashuf Fatima ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Adjuvant Chemotherapy ◽  
Advanced Breast Cancer ◽  
Treatment Response ◽  
Quantitative Ultrasound ◽  
Locally Advanced Breast Cancer ◽  
Locally Advanced ◽  
Advanced Breast ◽  
Neo Adjuvant Chemotherapy

scholarly journals Strain wave elastography in response assessment to neo-adjuvant chemotherapy in patients with locally advanced breast cancer

2019 ◽  
Vol 92 (1099) ◽  
pp. 20180515 ◽  
Author(s):  
Amit Katyan ◽  
Mahesh Kumar Mittal ◽  
Chinta Mani ◽  
Ashish Kumar Mandal
Keyword(s):  
Breast Cancer ◽  
Adjuvant Chemotherapy ◽  
Advanced Breast Cancer ◽  
Treatment Response ◽  
Locally Advanced Breast Cancer ◽  
Locally Advanced ◽  
Strain Ratio ◽  
Advanced Breast ◽  
Strain Wave ◽  
Neo Adjuvant Chemotherapy

Objective: The study was conducted to study the role of strain wave elastography in evaluating the response to neo-adjuvant chemotherapy (NACT) in patients with locally advanced breast cancer (LABC). Methods: In this Institutional review board approved study, 86 patients of LABC were investigated with strain wave elastography. Females receiving NACT had the affected breast scanned by strain wave elastography before each cycle of chemotherapy and immediately before surgery by two independent observers. Changes in elastographic parameters (size ratio, strain ratio) were documented and then compared to clinical and pathologic tumor response as evaluated after mastectomy. Results: Elastographic strain ratio parameters demonstrated high sensitivity and moderate specificity for determining response even after the first cycle of neo-adjuvant chemotherapy [97.7% sensitivity (Sn), 68.7% specificity (Sp)]. Elastographic size ratio parameters showed moderate sensitivity and specificity for response detection after second and third cycle of neo-adjuvant chemotherapy (Sn, Sp: after second cycle of NACT Sn 83.3% Sp 80%; after third cycle of NACT Sn 77.8% Sp 100%). Conclusion: Strain ratio is the earliest predictor of treatment response in patients of LABC. Serial imaging with elastography has the potential to predict treatment response early during the course of NACT, which may prove vital in management of patients with breast cancer. Advances in knowledge: Strain wave elastography is a powerful tool to predict chemoresponse early during the course of management, thereby providing an optimal window to change treatment protocols.

scholarly journals Locally advanced breast cancer in younger women

2003 ◽  
Vol 11 (3) ◽  
pp. 149-149
Author(s):  
Jadranka Lakicevic ◽  
Dinka Lakic ◽  
Milan Sorat
Keyword(s):  
Breast Cancer ◽  
Surgical Treatment ◽  
Adjuvant Chemotherapy ◽  
Advanced Breast Cancer ◽  
Locally Advanced Breast Cancer ◽  
Locally Advanced ◽  
Radical Mastectomy ◽  
Breast Conserving Surgery ◽  
Advanced Breast ◽  
Neo Adjuvant Chemotherapy

Background: Standard treatment of locally advanced breast cancer is not yet established. In most institutions treatment is multimodal and consists of primary chemotherapy, surgical treatment with or without radiotherapy (RT) and hormonal therapy. To find out whether the age influences the kind of surgical treatment in a group of locally advanced breast cancer patients (LABC patients) responding to neo-adjuvant chemotherapy. Methods: Analysis included 39 LABC patients treated from January 2000 till January 2003 with neo-adjuvant chemotherapy and surgical treatment in Clinical Center of Montenegro, Podgorica. All patients had locally advanced disease (T2, T3 or T4b and/or N1-2 M1 sc). Patients with T4d tumors were excluded. The treatment consisted of neo-adjuvant chemotherapy, mostly anthracycline based, and surgical treatment - radical mastectomy or breast conserving surgery. Additional procedures after surgical treatment included 3-4 cycles of the same chemotherapy, hormonal treatment and/or RT. Results: Median age of patients was 47 years (range: 24-67 years). Thirty patients were initially in stage IIIA (14 post- and 16 premenopausal patients respectively), 6 patients in stage IIIB (2 post- and 4 premenopausal respectively), and 3 patients in stage IV, with supraclavicular node involvement (M1+sc, 2 post- and 1 premenopausal, respectively). Applied preoperative chemotherapy was anthracycline-based regimen (FAC, 3-6 cycles) except in one patient in premenopausal group and 2 patients in postmenopausal group, who had been treated with CMF chemotherapy due to anthracycline contraindications. All analyzed patients responded to neo-adjuvant chemotherapy, mostly with partial or minimal remission of their tumors. In a whole group 15/39 (38%) patients had breast conserving surgery (8 pre-, 7 postmenopausal, respectively), 24/39 (61%) patients radical mastectomy (13 pre-, 11 postmenopausal, respectively). In a group of patients old 40 years and younger only 2 partial resections were performed (2/9, 22%), and 7 radical mastectomies. Conclusion: Although in a small group of patients, our results confirmed that effective neo-adjuvant chemotherapy enabled breast surgery of LABC, even breast conservative procedure in some patients. However, breast conservation was not possible in majority of young patients. This suggests the investigation of more aggressive neo-adjuvant treatments, especially in patients old 40 years or younger.

Proliferation Determined by ki67 Marker and pCR in Locally Advanced Breast Cancer Patients Treated with Neo-adjuvant Chemotherapy

2013 ◽  
Vol 19 (6) ◽  
pp. 685-686 ◽  
Author(s):  
Alfonso Sánchez-Muñoz ◽  
Yessica Plata-Fernández ◽  
Ana Jaén ◽  
María Lomas ◽  
Margarita Fernández ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Adjuvant Chemotherapy ◽  
Advanced Breast Cancer ◽  
Cancer Patients ◽  
Locally Advanced Breast Cancer ◽  
Locally Advanced ◽  
Advanced Breast ◽  
Breast Cancer Patients ◽  
Neo Adjuvant Chemotherapy
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