scholarly journals Resistance to allosteric SHP2 inhibition in FGFR-driven cancers through rapid feedback activation of FGFR

Oncotarget ◽  
2020 ◽  
Vol 11 (3) ◽  
pp. 265-281 ◽  
Author(s):  
Hengyu Lu ◽  
Chen Liu ◽  
Hung Huynh ◽  
Thi Bich Uyen Le ◽  
Matthew J. LaMarche ◽  
...  
Keyword(s):  
Feedback Activation

scholarly journals Combined SFK/mTOR Inhibition Prevents Rapamycin-Induced Feedback Activation of AKT and Elicits Efficient Tumor Regression

2014 ◽  
Vol 74 (17) ◽  
pp. 4762-4771 ◽  
Author(s):  
Jennifer L. Yori ◽  
Kristen L. Lozada ◽  
Darcie D. Seachrist ◽  
Jonathan D. Mosley ◽  
Fadi W. Abdul-Karim ◽  
...  
Keyword(s):  
Tumor Regression ◽  
Mtor Inhibition ◽  
Feedback Activation

scholarly journals Structural Evidence for Feedback Activation by Ras·GTP of the Ras-Specific Nucleotide Exchange Factor SOS

Cell ◽  
2003 ◽  
Vol 112 (5) ◽  
pp. 685-695 ◽  
Author(s):  
S.Mariana Margarit ◽  
Holger Sondermann ◽  
Brian E. Hall ◽  
Bhushan Nagar ◽  
Andre Hoelz ◽  
...  
Keyword(s):  
Nucleotide Exchange ◽  
Exchange Factor ◽  
Nucleotide Exchange Factor ◽  
Specific Nucleotide ◽  
Feedback Activation

scholarly journals Feedback activation in rat nephrons by sera from patients with acute renal failure

1980 ◽  
Vol 17 (4) ◽  
pp. 497-506 ◽  
Author(s):  
Peter F. Wunderlich ◽  
Felix P. Brunner ◽  
John M. Davis ◽  
Dieter A. Häberle ◽  
Heinrich Thölen ◽  
...  
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Feedback Activation

Abstract A90: Feedback activation of EGFR drives resistance to BRAF(V600E) inhibition in breast cancer.

2013 ◽  
Author(s):  
Yj Yang ◽  
HJ Na ◽  
Ws Kim ◽  
JP Bong ◽  
SJ Beak ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Braf V600e ◽  
Feedback Activation

Abstract 4151: Mutual feedback activation of PI3K and MAPK pathways support combining inhibitors of the two pathways to enhance efficacy

2010 ◽  
Author(s):  
Theresa Zhang ◽  
Igor Feldman ◽  
Cloud Paweletz ◽  
Michael Nebozhyn ◽  
Stuart Shumway Shumway ◽  
...  
Keyword(s):  
Mapk Pathways ◽  
Feedback Activation
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