scholarly journals Breathing the air of mitochondrial respiration via an important oncotarget - mitochondrial glycerophosphate dehydrogenase (mGPDH)

Oncotarget ◽  
2019 ◽  
Vol 10 (60) ◽  
pp. 6400-6402
Author(s):  
Shilpa Thakur ◽  
Joanna Klubo-Gwiezdzinska
Keyword(s):  
Mitochondrial Respiration ◽  
Glycerophosphate Dehydrogenase

Effects of 5-5'-Diphenyl-2-thiohydantoin (DPTH) and Thyroxine on the Ultrastructure and Chemical Composition of Rat Liver

1971 ◽  
Vol 29 ◽  
pp. 570-571
Author(s):  
E. A. Elfont ◽  
R. B. Tobin ◽  
D. G. Colton ◽  
M. A. Mehlman
Keyword(s):  
Chemical Composition ◽  
Rat Liver ◽  
Future Study ◽  
Mode Of Action ◽  
Liver Mitochondria ◽  
Rat Liver Mitochondria ◽  
Effective Inhibitor ◽  
Biochemical Effects ◽  
Glycerophosphate Dehydrogenase ◽  
Stimulation Of

Summary5,-5'-diphenyl-2-thiohydantoin (DPTH) is an effective inhibitor of thyroxine (T4) stimulation of α-glycerophosphate dehydrogenase in rat liver mitochondria. Because this finding indicated a possible tool for future study of the mode of action of thyroxine, the ultrastructural and biochemical effects of DPTH and/or thyroxine on rat liver mere investigated.Rats were fed either standard or DPTH (0.06%) diet for 30 days before T4 (250 ug/kg/day) was injected. Injection of T4 occurred daily for 10 days prior to sacrifice. After removal of the liver and kidneys, part of the tissue was frozen at -50°C for later biocheailcal analyses, while the rest was prefixed in buffered 3.5X glutaraldehyde (390 mOs) and post-fixed in buffered 1Z OsO4 (376 mOs). Tissues were embedded in Araldlte 502 and the sections examined in a Zeiss EM 9S.Hepatocytes from hyperthyroid rats (Fig. 2) demonstrated enlarged and more numerous mitochondria than those of controls (Fig. 1). Glycogen was almost totally absent from the cytoplasm of the T4-treated rats.

Metabolic endotoxaemia impairs mitochondrial respiration and insulin sensitivity in human adipocytes

2016 ◽  
Author(s):  
la Escalera Lucia Martinez de ◽  
Laura Jackisch ◽  
Alice Murphy ◽  
Milan Piya ◽  
Sudhesh Kumar ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Mitochondrial Respiration ◽  
Human Adipocytes

Continuous Adaptation of Rats to Hypobaric Hypoxia Prevents Stressor Hyperglycemia and Optimizes Mitochondrial Respiration in Acute Hypoxia

2013 ◽  
Vol 4 (2) ◽  
pp. 137-147
Author(s):  
Vladimir I. Portnichenko ◽  
Valentina I. Nosar ◽  
Alla M. Sydorenko ◽  
Alla G. Portnychenko ◽  
Irina N. Mankovska
Keyword(s):  
Mitochondrial Respiration ◽  
Hypobaric Hypoxia ◽  
Acute Hypoxia

Unaltered Fatty Acid Uptake, Utilization, and Mitochondrial Respiration in Right Atrial Appendage of Type 2 Diabetic Human Heart

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 335-OR
Author(s):  
NANDINI RJ ◽  
SR RAJI ◽  
VIVEK V. PILLAI ◽  
JAYAKUMAR K. ◽  
SRINIVAS GOPALA
Keyword(s):  
Fatty Acid ◽  
Mitochondrial Respiration ◽  
Human Heart ◽  
Fatty Acid Uptake ◽  
Atrial Appendage ◽  
Right Atrial ◽  
Acid Uptake ◽  
Right Atrial Appendage ◽  
Type 2 Diabetic

Cytotoxicity of Hydrazones of Morpholine Bearing Mannich Bases Towards Huh7 and T47D Cell Lines and Their Effects on Mitochondrial Respiration

2016 ◽  
Vol 13 (8) ◽  
pp. 734-741 ◽  
Author(s):  
Kaan Kucukoglu ◽  
Halise Inci Gul ◽  
Mustafa Gul ◽  
Rengul Cetin-Atalay ◽  
Yosra Baratli ◽  
...  
Keyword(s):  
Cell Lines ◽  
Mitochondrial Respiration ◽  
T47d Cell ◽  
Mannich Bases
Sign in / Sign up

Export Citation Format

Share Document