scholarly journals Comparative safety analysis of immunotherapy combined with chemotherapy versus monotherapy in solid tumors: a meta-analysis of randomized clinical trials

Oncotarget ◽  
2019 ◽  
Vol 10 (35) ◽  
pp. 3294-3301 ◽  
Author(s):  
Alberto Carretero-González ◽  
David Lora ◽  
Ismael Ghanem ◽  
Irene Otero ◽  
Flora López ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Solid Tumors ◽  
Randomized Clinical Trials ◽  
Meta Analysis ◽  
Safety Analysis ◽  
Comparative Safety

Toxicity profile of approved anti-PD1 monoclonal antibodies in solid tumors: A systematic review and meta-analysis of randomized clinical trials.

2016 ◽  
Vol 34 (15_suppl) ◽  
pp. 3064-3064 ◽  
Author(s):  
Ricardo Lima Barros Costa ◽  
Benedito A. Carneiro ◽  
Alfred Rademaker ◽  
Mark Agulnik ◽  
Victoria Meucci Villaflor ◽  
...  
Keyword(s):  
Systematic Review ◽  
Clinical Trials ◽  
Monoclonal Antibodies ◽  
Solid Tumors ◽  
Randomized Clinical Trials ◽  
Meta Analysis ◽  
Toxicity Profile

scholarly journals Toxicity profile of approved anti-PD-1 monoclonal antibodies in solid tumors: a systematic review and meta-analysis of randomized clinical trials

Oncotarget ◽  
2016 ◽  
Vol 8 (5) ◽  
pp. 8910-8920 ◽  
Author(s):  
Ricardo Costa ◽  
Benedito A. Carneiro ◽  
Mark Agulnik ◽  
Alfred W. Rademaker ◽  
Sachin G. Pai ◽  
...  
Keyword(s):  
Systematic Review ◽  
Clinical Trials ◽  
Monoclonal Antibodies ◽  
Solid Tumors ◽  
Randomized Clinical Trials ◽  
Meta Analysis ◽  
Toxicity Profile

scholarly journals Analysis of response rate with ANTI PD1/PD-L1 monoclonal antibodies in advanced solid tumors: a meta-analysis of randomized clinical trials

Oncotarget ◽  
2018 ◽  
Vol 9 (9) ◽  
pp. 8706-8715 ◽  
Author(s):  
Alberto Carretero-González ◽  
David Lora ◽  
Ismael Ghanem ◽  
Jon Zugazagoitia ◽  
Daniel Castellano ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Monoclonal Antibodies ◽  
Solid Tumors ◽  
Randomized Clinical Trials ◽  
Response Rate ◽  
Meta Analysis ◽  
Advanced Solid Tumors

Maternal and Neonatal Effect of Fentanyl as a Premedication before Induction of General Anesthesia in Cesarean Surgery: A Systematic Review and Meta-analysis of Randomized Clinical Trials

2019 ◽  
Vol 15 (4) ◽  
pp. 232-237
Author(s):  
Mir Hadi Musavi ◽  
Behzad Jodeiri ◽  
Keyvan Mirnia ◽  
Morteza Ghojazadeh ◽  
Zeinab Nikniaz
Keyword(s):  
Systematic Review ◽  
Clinical Trials ◽  
Cesarean Section ◽  
General Anesthesia ◽  
Apgar Score ◽  
Randomized Clinical Trials ◽  
Meta Analysis ◽  
Intravenous Fentanyl ◽  
Neonatal Effect ◽  
Fentanyl Group

Background: Although, some clinical trials investigated the maternal and neonatal effect of fentanyl as a premedication before induction of general anesthesia in cesarean section, to the best of our knowledge, there is no systematic review to summarize these results. Objectives: The present systematic review and meta-analysis evaluated the maternal and neonatal effect of intravenous fentanyl as a premedication before induction of general anesthesia in cesarean section. Methods: The databases of Pubmed, Embase, Scopus and Cochrane library were searched till July 2017 to identify randomized clinical trials which evaluated the effects of intravenous fentanyl as a premedication before induction of general anesthesia compared with placebo on neonate first and fifth minute Apgar score and maternal heart rate and mean arterial pressure (MAP) in cesarean section. Standard Mean difference (SMD) was calculated and I-square statistic test was used for heterogeneity analysis. Results: The present systematic review and meta-analysis consisted of three clinical trials including 180 women in labor. Considering the results of meta-analysis, there is no significant differences between fentanyl and placebo in the case of Apgar score at 1 minute; however, the Apgar score of 5 minutes was significantly lower in fentanyl group compared with placebo (SMD -0.68, 95%CI: - 0.98, -0.38, p<0.001). In the term of maternal hemodynamics, the heart rate (SMD -0.43, 95%CI: - 0.72, -0.13, p=0.004) and MAP (SMD -0.78, 95% CI: -1.09, -0.48, p<0.001) in fentanyl group were significantly lower compared with placebo group. Conclusion: The present meta-analysis showed that using intravenous fentanyl as a premedication before induction of general anesthesia had adverse effects on neonate Apgar score. However, it had positive effects on preventing adverse consequences of intubation on maternal hemodynamics.

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