scholarly journals A hint from zebrafish models of hepatic tumorigenesis: Targeting stearoyl-CoA desaturase

Oncotarget ◽  
2019 ◽  
Vol 10 (9) ◽  
pp. 924-925 ◽  
Author(s):  
Kunpeng Lv ◽  
Fei Fei ◽  
Xu Wang
Keyword(s):  
Stearoyl Coa Desaturase ◽  
Hepatic Tumorigenesis

Thiazolidinediones downregulate stearoyl-CoA desaturase 1 gene expression in 3T3-L1 adipocytes

Diabetes ◽  
1997 ◽  
Vol 46 (12) ◽  
pp. 2115-2118 ◽  
Author(s):  
S. Kurebayashi ◽  
T. Hirose ◽  
Y. Miyashita ◽  
S. Kasayama ◽  
T. Kishimoto
Keyword(s):  
Gene Expression ◽  
Stearoyl Coa Desaturase

scholarly journals Aramchol Downregulates Stearoyl CoA-Desaturase 1 in Hepatic Stellate Cells to Attenuate Cellular Fibrogenesis

JHEP Reports ◽  
2021 ◽  
pp. 100237
Author(s):  
Dipankar Bhattacharya ◽  
Brittany Basta ◽  
Jose M. Mato ◽  
Amanda Craig ◽  
David Fernández-Ramos ◽  
...  
Keyword(s):  
Hepatic Stellate Cells ◽  
Stellate Cells ◽  
Stearoyl Coa Desaturase

Novel polymorphisms in Stearoyl‐CoA Desaturase (SCD) and Fatty Acid Desaturase 2 (FADS2) in channel catfish ( Ictalurus punctatus, Rafinesque, 1818 )

2021 ◽  
Author(s):  
Oliva Mendoza‐Pacheco ◽  
Gaspar Manuel Parra‐Bracamonte ◽  
Xochitl Fabiola De la Rosa‐Reyna ◽  
Ana María Sifuentes‐Rincón ◽  
Isidro Otoniel Montelongo‐Alfaro ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Ictalurus Punctatus ◽  
Channel Catfish ◽  
Fatty Acid Desaturase ◽  
Stearoyl Coa Desaturase ◽  
Fatty Acid Desaturase 2

scholarly journals Lipidomics profiling of goose granulosa cell model of stearoyl-CoA desaturase function identifies a pattern of lipid droplets associated with follicle development

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Xin Yuan ◽  
Shenqiang Hu ◽  
Liang Li ◽  
Chunchun Han ◽  
Hehe Liu ◽  
...  
Keyword(s):  
Differentially Expressed Genes ◽  
Lipid Droplets ◽  
Cell Model ◽  
Enrichment Analysis ◽  
Differentially Expressed ◽  
Pathway Enrichment Analysis ◽  
Follicle Development ◽  
Microscopy Analysis ◽  
Stearoyl Coa Desaturase ◽  
Underlying Mechanisms

Abstract Background Despite their important functions and nearly ubiquitous presence in cells, an understanding of the biology of intracellular lipid droplets (LDs) in goose follicle development remains limited. An integrated study of lipidomic and transcriptomic analyses was performed in a cellular model of stearoyl-CoA desaturase (SCD) function, to determine the effects of intracellular LDs on follicle development in geese. Results Numerous internalized LDs, which were generally spherical in shape, were dispersed throughout the cytoplasm of granulosa cells (GCs), as determined using confocal microscopy analysis, with altered SCD expression affecting LD content. GC lipidomic profiling showed that the majority of the differentially abundant lipid classes were glycerophospholipids, including PA, PC, PE, PG, PI, and PS, and glycerolipids, including DG and TG, which enriched glycerophospholipid, sphingolipid, and glycerolipid metabolisms. Furthermore, transcriptomics identified differentially expressed genes (DEGs), some of which were assigned to lipid-related Gene Ontology slim terms. More DEGs were assigned in the SCD-knockdown group than in the SCD-overexpression group. Integration of the significant differentially expressed genes and lipids based on pathway enrichment analysis identified potentially targetable pathways related to glycerolipid/glycerophospholipid metabolism. Conclusions This study demonstrated the importance of lipids in understanding follicle development, thus providing a potential foundation to decipher the underlying mechanisms of lipid-mediated follicle development.

Loss of stearoyl-CoA desaturase 1 improves cardiac function in leptin-deficient ob/ob mice

2009 ◽  
Vol 160 ◽  
pp. S41-S42
Author(s):  
Pawel Dobrzyn ◽  
James M. Ntambi ◽  
Agnieszka Dobrzyn
Keyword(s):  
Cardiac Function ◽  
Stearoyl Coa Desaturase

Genetic variability of the Stearoyl-CoA desaturase gene in sheep

2009 ◽  
Vol 23 (2) ◽  
pp. 107-111 ◽  
Author(s):  
Marta García-Fernández ◽  
Beatriz Gutiérrez-Gil ◽  
Elsa García-Gámez ◽  
Juan-José Arranz
Keyword(s):  
Genetic Variability ◽  
Desaturase Gene ◽  
Stearoyl Coa Desaturase
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