scholarly journals Safety and effectiveness of FOLFOXIRI plus molecular target drug therapy for metastatic colorectal cancer: A multicenter retrospective study

Oncotarget ◽  
2019 ◽  
Vol 10 (10) ◽  
pp. 1070-1084 ◽  
Author(s):  
Takatsugu Ogata ◽  
Hironaga Satake ◽  
Misato Ogata ◽  
Yukimasa Hatachi ◽  
Hayato Maruoka ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Retrospective Study ◽  
Drug Therapy ◽  
Metastatic Colorectal Cancer ◽  
Molecular Target ◽  
Target Drug ◽  
Molecular Target Drug

Guideline-recommended incorporation of biomarker testing results in metastatic colorectal cancer therapy

2020 ◽  
Vol 17 (3) ◽  
pp. 185-194
Author(s):  
Jared Freml ◽  
Thomas Delate ◽  
Jesus Hermosillo-Rodriguez
Keyword(s):  
Colorectal Cancer ◽  
Retrospective Study ◽  
Cancer Therapy ◽  
Metastatic Colorectal Cancer ◽  
Small Proportion ◽  
Biomarker Testing ◽  
Over Time

Aim: To describe pharmacogenomic tumor testing among patients with metastatic colorectal cancer. Methods: This was a retrospective study of patients with metastatic colorectal cancer diagnosed between 1 January 2014 and 30 June 2018. Patients were assessed for pharmacogenomic testing and appropriateness of chemotherapy use. Results: Overall, 112/167 (67.1%) patients had at least one of the three recommended pharmacogenomic tests and 41/167 (24.6%) had all tests. Twenty-four patients were treated with cetuximab with 8/167 (4.7%) identified as being treated with a RAS variant (n = 3) or incomplete testing (n = 5); thus, not in accordance with guidelines. Conclusion: Uptake of testing was variable but increased over time; however, a small proportion of patients received cetuximab with a variant or not all recommended tests being performed.

scholarly journals Raltitrexed as salvage therapy for metastatic colorectal cancer: A multicenter retrospective study

2018 ◽  
Vol 29 ◽  
pp. v78
Author(s):  
I. Ghanem ◽  
A. Viudez ◽  
E. García-Torralba ◽  
J. Torres-Tenor ◽  
A. Carmona ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Retrospective Study ◽  
Metastatic Colorectal Cancer ◽  
Salvage Therapy

Maintenance single-agent bevacizumab or observation after first-line chemotherapy in patients with metastatic colorectal cancer: a multicenter retrospective study

2013 ◽  
Vol 31 (4) ◽  
pp. 1035-1043 ◽  
Author(s):  
Luca Moscetti ◽  
Fabrizio Nelli ◽  
Maria A Fabbri ◽  
Isabella Sperduti ◽  
Daniele Alesini ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Retrospective Study ◽  
Metastatic Colorectal Cancer ◽  
Single Agent ◽  
First Line ◽  
Line Chemotherapy
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