scholarly journals Correction: Aryl hydrocarbon receptor regulates histone deacetylase 8 expression to repress tumor suppressive activity in hepatocellular carcinoma

Oncotarget ◽  
2018 ◽  
Vol 9 (102) ◽  
pp. 37807-37807
Author(s):  
Li-Ting Wang ◽  
Shyh-Shin Chiou ◽  
Chee-Yin Chai ◽  
Edward Hsi ◽  
Shen-Nien Wang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Aryl Hydrocarbon Receptor ◽  
Histone Deacetylase ◽  
Suppressive Activity ◽  
Aryl Hydrocarbon ◽  
Histone Deacetylase 8

scholarly journals Aryl hydrocarbon receptor regulates histone deacetylase 8 expression to repress tumor suppressive activity in hepatocellular carcinoma

Oncotarget ◽  
2016 ◽  
Vol 8 (5) ◽  
pp. 7489-7501 ◽  
Author(s):  
Li-Ting Wang ◽  
Shyh-Shin Chiou ◽  
Chee-Yin Chai ◽  
Edward Hsi ◽  
Shen-Nien Wang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Aryl Hydrocarbon Receptor ◽  
Histone Deacetylase ◽  
Suppressive Activity ◽  
Aryl Hydrocarbon ◽  
Histone Deacetylase 8

scholarly journals TDO2 Promotes the EMT of Hepatocellular Carcinoma Through Kyn-AhR Pathway

2021 ◽  
Vol 10 ◽  
Author(s):  
Lei Li ◽  
Tao Wang ◽  
Shanbao Li ◽  
Zhengqian Chen ◽  
Junyi Wu ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Aryl Hydrocarbon Receptor ◽  
Cancer Metastasis ◽  
Epithelial To Mesenchymal Transition ◽  
Migration And Invasion ◽  
Mesenchymal Transition ◽  
Aryl Hydrocarbon ◽  
Hcc Cells

Tryptophan 2,3-dioxygenase (TDO2), an enzyme involved in tryptophan (Trp) metabolism has been linked with some malignant traits of various cancers. Kyn, the main product of Trp metabolism pathway catalyzed by TDO2 and indoleamine 2,3-dioxygenase (IDO) in tumor cells, was also demonstrated to activate aryl hydrocarbon receptor (AhR), which may regulate cancer growth and invasion in some malignancies. However, whether TDO2 participates in the metastasis and invasion of HCC has not been explored before. The underlying mechanism played by TDO2 in this process still requires further investigation. Here, we demonstrated that overexpression of TDO2 correlates with advanced stage or malignant traits in HCC patients. Knockdown or inhibition of TDO2 suppressed the migration and invasion of HCC cells in vitro and in vivo. Epithelial to mesenchymal transition (EMT) is an essential program happened in the initial phase of cancer metastasis. We found that in HCC cells, TDO2 promoted the EMT process evidenced by altered levels of biomarkers for EMT. Mechanically, TDO2 regulated the Kyn production in HCC cell via activated aryl hydrocarbon receptor (AhR). Together, these results indicate that TDO2 promotes the EMT of hepatocellular carcinoma through activating Kyn-AhR pathway, thereby participating in the metastasis and invasion of HCC.

Aryl hydrocarbon receptor promotes hepatocellular carcinoma tumorigenesis by targeting intestine-specific homeobox expression

2017 ◽  
Vol 56 (10) ◽  
pp. 2167-2177 ◽  
Author(s):  
Shih-Hsien Hsu ◽  
Li-Ting Wang ◽  
Chee-Yin Chai ◽  
Chi-Cheng Wu ◽  
Edward Hsi ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Aryl Hydrocarbon Receptor ◽  
Aryl Hydrocarbon

Aryl hydrocarbon receptor nuclear translocator is associated with tumor growth and progression of hepatocellular carcinoma

2011 ◽  
Vol 130 (8) ◽  
pp. 1745-1754 ◽  
Author(s):  
Ying Liang ◽  
Wei-Wei Li ◽  
Bi-Wei Yang ◽  
Zhong-Hua Tao ◽  
Hui-Chuan Sun ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Tumor Growth ◽  
Aryl Hydrocarbon Receptor ◽  
Aryl Hydrocarbon

The Up-Regulation of Histone Deacetylase 8 Promotes Proliferation and Inhibits Apoptosis in Hepatocellular Carcinoma

2013 ◽  
Vol 58 (12) ◽  
pp. 3545-3553 ◽  
Author(s):  
Jian Wu ◽  
Chengli Du ◽  
Zhen Lv ◽  
Chaofeng Ding ◽  
Jun Cheng ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Histone Deacetylase ◽  
Histone Deacetylase 8
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