scholarly journals Glyoxalase 1 gene is highly expressed in basal-like human breast cancers and contributes to survival of ALDH1-positive breast cancer stem cells

Oncotarget ◽  
2018 ◽  
Vol 9 (92) ◽  
pp. 36515-36529 ◽  
Author(s):  
Shoma Tamori ◽  
Yuka Nozaki ◽  
Hitomi Motomura ◽  
Hiromi Nakane ◽  
Reika Katayama ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Breast Cancer Stem Cells ◽  
Breast Cancers ◽  
Human Breast ◽  
Glyoxalase 1 ◽  
Positive Breast Cancer

scholarly journals TrkA Interacts with and Phosphorylates STAT3 to Enhance Gene Transcription and Promote Breast Cancer Stem Cells in Triple-Negative and HER2-Enriched Breast Cancers

Cancers ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 2340
Author(s):  
Angelina T. Regua ◽  
Noah R. Aguayo ◽  
Sara Abu Jalboush ◽  
Daniel L. Doheny ◽  
Sara G. Manore ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Gene Transcription ◽  
Target Genes ◽  
Triple Negative ◽  
Breast Cancer Stem Cells ◽  
Breast Cancers ◽  
Co Activation ◽  
Stat3 Phosphorylation

JAK2–STAT3 and TrkA signaling pathways have been separately implicated in aggressive breast cancers; however, whether they are co-activated or undergo functional interaction has not been thoroughly investigated. Herein we report, for the first time that STAT3 and TrkA are significantly co-overexpressed and co-activated in triple-negative breast cancer (TNBC) and HER2-enriched breast cancer, as shown by immunohistochemical staining and data mining. Through immunofluorescence staining–confocal microscopy and immunoprecipitation–Western blotting, we found that TrkA and STAT3 co-localize and physically interact in the cytoplasm, and the interaction is dependent on STAT3-Y705 phosphorylation. TrkA–STAT3 interaction leads to STAT3 phosphorylation at Y705 by TrkA in breast cancer cells and cell-free kinase assays, indicating that STAT3 is a novel substrate of TrkA. β-NGF-mediated TrkA activation induces TrkA–STAT3 interaction, STAT3 nuclear transport and transcriptional activity, and the expression of STAT3 target genes, SOX2 and MYC. The co-activation of both pathways promotes breast cancer stem cells. Finally, we found that TNBC and HER2-enriched breast cancer with JAK2–STAT3 and TrkA co-activation are positively associated with poor overall metastasis-free and organ-specific metastasis-free survival. Collectively, our study uncovered that TrkA is a novel activating kinase of STAT3, and their co-activation enhances gene transcription and promotes breast cancer stem cells in TNBC and HER2-enriched breast cancer.

scholarly journals MicroRNA Regulation of Human Breast Cancer Stem Cells

2015 ◽  
Vol 5 (1) ◽  
pp. 2 ◽  
Author(s):  
Yohei Shimono ◽  
Junko Mukohyama ◽  
Shun-ichi Nakamura ◽  
Hironobu Minami
Keyword(s):  
Breast Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Stem Cells ◽  
Human Breast ◽  
Microrna Regulation

scholarly journals Doxycycline targets aldehyde dehydrogenase‑positive breast cancer stem cells

2018 ◽  
Author(s):  
Chang‑Ching Lin ◽  
Miao‑Chia Lo ◽  
Rebecca Moody ◽  
Nicholas Stevers ◽  
Samantha Tinsley ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Aldehyde Dehydrogenase ◽  
Breast Cancer Stem Cells ◽  
Positive Breast Cancer

scholarly journals Anticancer Activities of the Methanolic Extract from Lemon Leaves in Human Breast Cancer Stem Cells

2015 ◽  
Vol 58 (3) ◽  
pp. 219-226 ◽  
Author(s):  
Jeong Yong Moon ◽  
Linh Thi Thao Nguyen ◽  
Ho Bong Hyun ◽  
Ahmed Osman ◽  
Minwhan Cho ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Human Breast Cancer ◽  
Methanolic Extract ◽  
Breast Cancer Stem Cells ◽  
Human Breast ◽  
Anticancer Activities

Abstract A54: STAT3 as a novel therapeutic target in human breast cancer stem cells

2009 ◽  
Author(s):  
Li Lin ◽  
Brian Hutzen ◽  
Zhengang Peng ◽  
Huey‐Jen Lin ◽  
Pui‐Kai Li ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Therapeutic Target ◽  
Human Breast Cancer ◽  
Breast Cancer Stem Cells ◽  
Human Breast ◽  
Novel Therapeutic

scholarly journals PPARγ maintains ERBB2-positive breast cancer stem cells

Oncogene ◽  
2013 ◽  
Vol 32 (49) ◽  
pp. 5512-5521 ◽  
Author(s):  
X Wang ◽  
Y Sun ◽  
J Wong ◽  
D S Conklin
Keyword(s):  
Breast Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Breast Cancer Stem Cells ◽  
Positive Breast Cancer
Sign in / Sign up

Export Citation Format

Share Document