scholarly journals CXCR4- and BCR-triggered integrin activation in B-cell chronic lymphocytic leukemia cells depends on JAK2-activated Bruton’s tyrosine kinase

Oncotarget ◽  
2018 ◽  
Vol 9 (80) ◽  
pp. 35123-35140 ◽  
Author(s):  
Alessio Montresor ◽  
Lara Toffali ◽  
Antonella Rigo ◽  
Isacco Ferrarini ◽  
Fabrizio Vinante ◽  
...  
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Tyrosine Kinase ◽  
B Cell ◽  
Lymphocytic Leukemia ◽  
Leukemia Cells ◽  
Bruton’S Tyrosine Kinase ◽  
Integrin Activation ◽  
Bruton's Tyrosine Kinase ◽  
Cell Chronic Lymphocytic Leukemia

scholarly journals JAK2 tyrosine kinase mediates integrin activation induced by CXCL12 in B-cell chronic lymphocytic leukemia

Oncotarget ◽  
2015 ◽  
Vol 6 (33) ◽  
pp. 34245-34257 ◽  
Author(s):  
Alessio Montresor ◽  
Lara Toffali ◽  
Michela Mirenda ◽  
Antonella Rigo ◽  
Fabrizio Vinante ◽  
...  
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Tyrosine Kinase ◽  
B Cell ◽  
Lymphocytic Leukemia ◽  
Integrin Activation ◽  
Cell Chronic Lymphocytic Leukemia

scholarly journals Disseminated Cryptococcal Disease in a Patient with Chronic Lymphocytic Leukemia on Ibrutinib

2016 ◽  
Vol 2016 ◽  
pp. 1-3 ◽  
Author(s):  
Koh Okamoto ◽  
Laurie A. Proia ◽  
Patricia L. Demarais
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Tyrosine Kinase ◽  
B Cell ◽  
Lymphocytic Leukemia ◽  
Biologic Agent ◽  
Cell Mediated Immunity ◽  
Bruton’S Tyrosine Kinase ◽  
Bruton's Tyrosine Kinase ◽  
First Case ◽  
Cryptococcal Disease

Cryptococcusis a unique environmental fungus that can cause disease most often in immunocompromised individuals with defective cell-mediated immunity. Chronic lymphocytic leukemia (CLL) is not known to be a risk factor for cryptococcal disease although cases have been described mainly in patients treated with agents that suppress cell-mediated immunity. Ibrutinib is a new biologic agent used for treatment of CLL, mantle cell lymphoma, and Waldenstrom’s macroglobulinemia. It acts by inhibiting Bruton’s tyrosine kinase, a kinase downstream of the B-cell receptor critical for B-cell survival and proliferation. Ibrutinib use has not been associated previously with cryptococcal disease. However, recent evidence suggested that treatments aimed at blocking the function of Bruton’s tyrosine kinase could pose a higher risk for cryptococcal infection in a mice model. Here, we report the first case of disseminated cryptococcal disease in a patient with CLL treated with ibrutinib. When evaluating possible infection in CLL patients receiving ibrutinib, cryptococcal disease, which could be life threatening if overlooked, could be considered.

A novel monoclonal antibody recognizing human thymocytes and B-cell chronic lymphocytic leukemia cells

1994 ◽  
Vol 39 (2) ◽  
pp. 137-146 ◽  
Author(s):  
P. Tassone ◽  
P. Bonelli ◽  
F. Tuccillo ◽  
H.M. Bond ◽  
M.C. Turco ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Chronic Lymphocytic Leukemia ◽  
B Cell ◽  
Lymphocytic Leukemia ◽  
Leukemia Cells ◽  
Cell Chronic Lymphocytic Leukemia

scholarly journals Enhanced CDC of B cell chronic lymphocytic leukemia cells mediated by rituximab combined with a novel anti-complement factor H antibody

PLoS ONE ◽  
2017 ◽  
Vol 12 (6) ◽  
pp. e0179841 ◽  
Author(s):  
Mark T. Winkler ◽  
Ryan T. Bushey ◽  
Elizabeth B. Gottlin ◽  
Michael J. Campa ◽  
Eross S. Guadalupe ◽  
...  
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
B Cell ◽  
Factor H ◽  
Lymphocytic Leukemia ◽  
Complement Factor H ◽  
Leukemia Cells ◽  
Complement Factor ◽  
Cell Chronic Lymphocytic Leukemia

scholarly journals Myelo-Monocytoid Immunophenotypes of B-Cell Chronic Lymphocytic Leukemia Cells.

1993 ◽  
Vol 32 (7) ◽  
pp. 533-539 ◽  
Author(s):  
Hiroyuki TSUDA ◽  
Shintaro MATSUMI ◽  
Hiromichi NISHIMURA ◽  
Fumio KAWANO ◽  
Tadahiro SHIDO ◽  
...  
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
B Cell ◽  
Lymphocytic Leukemia ◽  
Leukemia Cells ◽  
Cell Chronic Lymphocytic Leukemia

scholarly journals The CD49d/CD29 complex is physically and functionally associated with CD38 in B-cell chronic lymphocytic leukemia cells

Leukemia ◽  
2012 ◽  
Vol 26 (6) ◽  
pp. 1301-1312 ◽  
Author(s):  
A Zucchetto ◽  
T Vaisitti ◽  
D Benedetti ◽  
E Tissino ◽  
V Bertagnolo ◽  
...  
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
B Cell ◽  
Lymphocytic Leukemia ◽  
Leukemia Cells ◽  
Cell Chronic Lymphocytic Leukemia
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