scholarly journals miR-665 targets c-MYC and HDAC8 to inhibit murine neuroblastoma cell growth

Oncotarget ◽  
2018 ◽  
Vol 9 (69) ◽  
pp. 33186-33201 ◽  
Author(s):  
Nagindra Prashad
Keyword(s):  
Cell Growth ◽  
Neuroblastoma Cell ◽  
Murine Neuroblastoma

2-Deoxyglucose treatment complements the cisplatin- or BH3-only mimetic-induced suppression of neuroblastoma cell growth

2013 ◽  
Vol 45 (5) ◽  
pp. 944-951 ◽  
Author(s):  
Jiin-Haur Chuang ◽  
Ming-Huei Chou ◽  
Ming-Hong Tai ◽  
Tsu-Kung Lin ◽  
Chia-Wei Liou ◽  
...  
Keyword(s):  
Cell Growth ◽  
Neuroblastoma Cell

scholarly journals Effects of serum and insulin-like growth factors on human neuroblastoma cell growth

1993 ◽  
Vol 48 (1-2) ◽  
pp. 217-224 ◽  
Author(s):  
Mihir A. Meghani ◽  
Donna M. Martin ◽  
J.Robinson Singleton ◽  
Eva L. Feldman
Keyword(s):  
Growth Factors ◽  
Cell Growth ◽  
Neuroblastoma Cell ◽  
Human Neuroblastoma Cell ◽  
Human Neuroblastoma ◽  
Insulin Like Growth Factors

The role of EGFR trafficking in neuroblastoma

2007 ◽  
Vol 25 (18_suppl) ◽  
pp. 20003-20003
Author(s):  
P. E. Zage ◽  
Q. Yan ◽  
L. Zeng ◽  
A. J. Bean
Keyword(s):  
Growth Factor ◽  
Cell Growth ◽  
Cell Lines ◽  
Neuroblastoma Cell ◽  
Growth Factor Receptor ◽  
Growth Factor Receptors ◽  
Human Neuroblastoma ◽  
Degradation Rates ◽  
Neuroblastoma Cell Lines

20003 Background: Signaling through growth factor receptors is important in neuroblastoma pathogenesis. Chromosome 1p36 is commonly deleted in neuroblastoma tumors and is associated with a poor prognosis. UBE4B, a gene in 1p36, has been reported mutated in high- risk neuroblastoma. We have found a direct interaction between UBE4B and hrs, a protein required for epidermal growth factor receptor (EGFR) trafficking, suggesting a link between EGFR trafficking and neuroblastoma pathogenesis. We have analyzed the role of UBE4B in the EGFR pathway in neuroblastoma cell lines. Methods: The expression of UBE4B, hrs and EGFR were analyzed by quantitative Western blot in a panel of 7 human neuroblastoma cell lines (SHEP, SKNAS, SKNSH, KCNR, SY5Y, LA155N, NGP). EGFR degradation rates were determined by examining the kinetics of cellular EGFR depletion following a pulse of ligand. Results: UBE4B levels were lowest in SKNAS and highest in NGP cells. Hrs levels were lowest in SKNSH cells and higher in other cell lines. EGFR levels were lowest in NGP and KCNR and highest in SKNAS cells. UBE4B levels were correlated with known 1p deletions. EGFR degradation rates were slowest in SKNAS cells and therefore correlated with cellular UBE4B levels. The low degradation rates were correlated with high cellular levels of EGFR. Conclusions: Expression levels of UBE4B are correlated in neuroblastoma cell lines with chromosome 1p deletions. Cell lines with lower levels of UBE4B degrade EGFR at a markedly slower rate, correlated with higher cellular EGFR levels. We hypothesize that UBE4B affects cell growth by interacting with hrs, directing EGFR for degradation. In its absence the ability of a cell to sort growth factor receptors for degradation is inhibited, resulting in growth factor receptor overabundance and uncontrolled cell growth. These results support the testing of EGFR inhibitors in a future phase I trial for children with neuroblastoma. No significant financial relationships to disclose.

Tetrahydrobiopterin Biosynthesis Enhanced by Lipopolysaccharide Stimulation in Murine Neuroblastoma Cell Line N1E-115

2002 ◽  
Vol 67 (6) ◽  
pp. 2540-2548 ◽  
Author(s):  
Akira Ota ◽  
Satoshi Yoshida ◽  
Takahide Nomura ◽  
Shigeru Matsui ◽  
Yasumichi Hagino ◽  
...  
Keyword(s):  
Cell Line ◽  
Neuroblastoma Cell ◽  
Neuroblastoma Cell Line ◽  
Murine Neuroblastoma
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