scholarly journals Vitamin C promotes decitabine or azacytidine induced DNA hydroxymethylation and subsequent reactivation of the epigenetically silenced tumour suppressor CDKN1A in colon cancer cells

Oncotarget ◽  
2018 ◽  
Vol 9 (67) ◽  
pp. 32822-32840 ◽  
Author(s):  
Christian Gerecke ◽  
Fabian Schumacher ◽  
Alexander Edlich ◽  
Alexandra Wetzel ◽  
Guy Yealland ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Vitamin C ◽  
Cancer Cells ◽  
Tumour Suppressor ◽  
Colon Cancer Cells ◽  
Dna Hydroxymethylation

scholarly journals Vitamin C in combination with inhibition of mutant IDH1 synergistically activates TET enzymes and epigenetically modulates gene silencing in colon cancer cells

Epigenetics ◽  
2019 ◽  
Vol 15 (3) ◽  
pp. 307-322
Author(s):  
Christian Gerecke ◽  
Fabian Schumacher ◽  
Alide Berndzen ◽  
Thomas Homann ◽  
Burkhard Kleuser
Keyword(s):  
Colon Cancer ◽  
Vitamin C ◽  
Gene Silencing ◽  
Cancer Cells ◽  
Colon Cancer Cells ◽  
Mutant Idh1 ◽  
Tet Enzymes

Combined treatment with vitamin C and sulindac synergistically induces p53- and ROS-dependent apoptosis in human colon cancer cells

2016 ◽  
Vol 258 ◽  
pp. 126-133 ◽  
Author(s):  
Eun-Yeung Gong ◽  
Yu Jin Shin ◽  
Ih-Yeon Hwang ◽  
Jeong Hee Kim ◽  
Seung-Mi Kim ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Vitamin C ◽  
Cancer Cells ◽  
Combined Treatment ◽  
Human Colon ◽  
Colon Cancer Cells ◽  
Human Colon Cancer ◽  
Human Colon Cancer Cells

scholarly journals Vitamin C increases the apoptosis via up-regulation p53 during cisplatin treatment in human colon cancer cells

BMB Reports ◽  
2011 ◽  
Vol 44 (3) ◽  
pp. 211-216 ◽  
Author(s):  
Sung-Ho An ◽  
Jung-Hoon Kang ◽  
Dong-Heui Kim ◽  
Myeong-Seon Lee
Keyword(s):  
Colon Cancer ◽  
Vitamin C ◽  
Cancer Cells ◽  
Human Colon ◽  
Colon Cancer Cells ◽  
Human Colon Cancer ◽  
Human Colon Cancer Cells

Alterations in tumour suppressor gene p53 correlate with inhibition of thrombospondin-1 gene expression in colon cancer cells

1998 ◽  
Vol 433 (5) ◽  
pp. 415-418 ◽  
Author(s):  
Tetsuji Tokunaga ◽  
M. Nakamura ◽  
Yoshiro Oshika ◽  
Takashi Tsuchida ◽  
Michitake Kazuno ◽  
...  
Keyword(s):  
Gene Expression ◽  
Colon Cancer ◽  
Cancer Cells ◽  
Suppressor Gene ◽  
Tumour Suppressor Gene ◽  
Tumour Suppressor ◽  
Colon Cancer Cells ◽  
Thrombospondin 1

Leptin is a growth factor for human colon cancer cells

2001 ◽  
Vol 120 (5) ◽  
pp. A493-A493
Author(s):  
J HARDWICK ◽  
G VANDENBRINK ◽  
S VANDEVENTER ◽  
M PEPPELENBOSCH
Keyword(s):  
Colon Cancer ◽  
Growth Factor ◽  
Cancer Cells ◽  
Human Colon ◽  
Colon Cancer Cells ◽  
Human Colon Cancer ◽  
Human Colon Cancer Cells

Silencing of a death associated protein kinase as a pro-survival factor in colon cancer cells

Endoscopy ◽  
2005 ◽  
Vol 37 (05) ◽  
Author(s):  
GA Doherty ◽  
SM Byrne ◽  
SC Austin ◽  
GM Scully ◽  
EW Kay ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Protein Kinase ◽  
Cancer Cells ◽  
Colon Cancer Cells ◽  
Survival Factor ◽  
Death Associated Protein Kinase

Cytotoxic Effect of the Combination of Gemcitabine and Atorvastatin Loaded in Microemulsion on the HCT116 Colon Cancer Cells

2017 ◽  
Vol 9 (2) ◽  
Author(s):  
Mayson H. Alkhatib ◽  
Dalal Al-Saedi ◽  
Wadiah S. Backer
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Anticancer Drugs ◽  
Therapeutic Potential ◽  
Morphological Changes ◽  
In Vitro Study ◽  
Colon Cancer Cells ◽  
Apoptosis Detection ◽  
Hct116 Cells

The combination of anticancer drugs in nanoparticles has great potential as a promising strategy to maximize efficacies by eradicating resistant, reduce the dosage of the drug and minimize toxicities on the normal cells. Gemcitabine (GEM), a nucleoside analogue, and atorvastatin (ATV), a cholesterol lowering agent, have shown anticancer effect with some limitations. The objective of this in vitro study was to evaluate the antitumor activity of the combination therapy of GEM and ATVencapsulated in a microemulsion (ME) formulation in the HCT116 colon cancer cells. The cytotoxicity and efficacy of the formulation were assessed by the 3- (4,5dimethylthiazole-2-yl)-2,5-diphyneltetrazolium bromide (MTT) assay. The mechanism of cell death was examined by observing the morphological changes of treated cells under light microscope, identifying apoptosis by using the ApopNexin apoptosis detection kit, and viewing the morphological changes in the chromatin structure stained with 4′,6-diamidino-2-phenylindole (DAPI) under the inverted fluorescence microscope. It has been found that reducing the concentration of GEM loaded on ME (GEM-ME) from 5μM to 1.67μM by combining it with 3.33μM of ATV in a ME formulation (GEM/2ATV-ME) has preserved the strong cytotoxicity of GEM-ME against HCT116 cells. The current study proved that formulating GEM with ATV in ME has improved the therapeutic potential of GEM and ATV as anticancer drugs.

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