scholarly journals A novel fatty acid-binding protein 5-estrogen-related receptor α signaling pathway promotes cell growth and energy metabolism in prostate cancer cells

Oncotarget ◽  
2018 ◽  
Vol 9 (60) ◽  
pp. 31753-31770 ◽  
Author(s):  
Shogo Senga ◽  
Koichiro Kawaguchi ◽  
Narumi Kobayashi ◽  
Akira Ando ◽  
Hiroshi Fujii
Keyword(s):  
Prostate Cancer ◽  
Fatty Acid ◽  
Energy Metabolism ◽  
Cell Growth ◽  
Cancer Cells ◽  
Fatty Acid Binding Protein ◽  
Prostate Cancer Cells ◽  
Fatty Acid Binding ◽  
Acid Binding Protein ◽  
Estrogen Related Receptor

scholarly journals In Vitro Study of Breast Cancer Cells Exposed to Antisense of Liver Fatty Acid Binding Protein

2006 ◽  
Vol 20 (4) ◽  
Author(s):  
Stacy‐Ann Miller ◽  
Byron Waddy ◽  
Nabarun Chakraborty ◽  
Rasha Hammamieh ◽  
Marti Jett
Keyword(s):  
Breast Cancer ◽  
Fatty Acid ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Fatty Acid Binding Protein ◽  
In Vitro Study ◽  
Liver Fatty Acid ◽  
Fatty Acid Binding ◽  
Acid Binding Protein

scholarly journals Involvement of Fatty Acid Binding Protein 5 and PPARβ/δin Prostate Cancer Cell Growth

PPAR Research ◽  
2010 ◽  
Vol 2010 ◽  
pp. 1-9 ◽  
Author(s):  
Elwin Morgan ◽  
Padmamalini Kannan-Thulasiraman ◽  
Noa Noy
Keyword(s):  
Prostate Cancer ◽  
Fatty Acid ◽  
Cancer Cell ◽  
Fatty Acid Binding Protein ◽  
Target Genes ◽  
Prostate Cancer Cell ◽  
Binding Protein ◽  
Fatty Acid Binding ◽  
General Role ◽  
Acid Binding Protein

Fatty acid binding protein 5 (FABP5) delivers ligands from the cytosol directly to the nuclear receptor PPARβ/δand thus facilitates the ligation and enhances the transcriptional activity of the receptor. We show here that expression levels of both FABP5 and PPARβ/δare correlated with the tumorigenic potential of prostate cancer cell lines. We show further that FABP5 comprises a direct target gene for PPARβ/δand thus the binding protein and its cognate receptor are engaged in a positive feedback loop. The observations demonstrate that, similarly to effects observed in mammary carcinomas, activation of the FABP5/PPARβ/δpathway induces PPARβ/δtarget genes involved in cell survival and growth and enhances cell proliferation and anchorage-independent growth in prostate cancer cells. Furthermore, the data show that downregulation of either FABP5 or PPARβ/δinhibits the growth of the highly malignant prostate cancer PC3M cells. These studies suggest that the FABP5/PPARβ/δpathway may play a general role in facilitating tumor progression and that inhibition of the pathway may comprise a novel strategy in treatment of cancer.

scholarly journals Docetaxel/cabazitaxel and fatty acid binding protein 5 inhibitors produce synergistic inhibition of prostate cancer growth

The Prostate ◽  
2019 ◽  
Vol 80 (1) ◽  
pp. 88-98 ◽  
Author(s):  
Gregory Carbonetti ◽  
Cynthia Converso ◽  
Timothy Clement ◽  
Changwei Wang ◽  
Lloyd C Trotman ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Fatty Acid ◽  
Fatty Acid Binding Protein ◽  
Binding Protein ◽  
Cancer Growth ◽  
Fatty Acid Binding ◽  
Synergistic Inhibition ◽  
Acid Binding Protein
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