scholarly journals Cooperation between BRCA1 and vitamin D is critical for histone acetylation of the p21waf1 promoter and for growth inhibition of breast cancer cells and cancer stem-like cells.

Oncotarget ◽  
2014 ◽  
Vol 5 (23) ◽  
pp. 11827-11846 ◽  
Author(s):  
Itay Pickholtz ◽  
Shira Saadyan ◽  
Gilmor I. Keshet ◽  
Victor S. Wang ◽  
Rachel Cohen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Vitamin D ◽  
Growth Inhibition ◽  
Histone Acetylation ◽  
Cancer Cells ◽  
Breast Cancer Cells

Melatonin and vitamin D3 synergistically down-regulate Akt and MDM2 leading to TGFβ-1-dependent growth inhibition of breast cancer cells

2010 ◽  
pp. no-no ◽  
Author(s):  
Sara Proietti ◽  
Alessandra Cucina ◽  
Fabrizio D’Anselmi ◽  
Simona Dinicola ◽  
Alessia Pasqualato ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Growth Inhibition ◽  
Cancer Cells ◽  
Vitamin D3 ◽  
Breast Cancer Cells ◽  
Dependent Growth

VITAMIN D DERIVATIVES IN COMBINATION WITH 9-cis RETINOIC ACID PROMOTE ACTIVE CELL DEATH IN BREAST CANCER CELLS

1995 ◽  
Vol 14 (3) ◽  
pp. 391-394 ◽  
Author(s):  
S Y James ◽  
A G Mackay ◽  
K W Colston
Keyword(s):  
Breast Cancer ◽  
Vitamin D ◽  
Retinoic Acid ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
P53 Protein ◽  
Protein A ◽  
Therapeutic Implications ◽  
Protein Levels ◽  
Mcf 7

ABSTRACT The effects of the novel vitamin D analogue, EB1089 alone, or in combination with the retinoid, 9-cis retinoic acid (9-cis RA) on indices of apoptosis in MCF-7 breast cancer cells have been examined. EB1089 was capable of reducing bcl-2 protein, a suppressor of apoptosis, and increasing p53 protein levels in MCF-7 cell cultures following 96h treatment. In the presence of 9-cis RA, EB1089 acted to further enhance the down-regulation and up-regulation of bcl-2 and p53 respectively. Furthermore, EB1089 induces DNA fragmentation in MCF-7 cells, a key feature of apoptosis, alone and in combination with 9-cis RA in situ. The observation that EB1089 and 9-cis RA act in a cooperative manner to enhance induction of apoptosis in these cells may have therapeutic implications.

Nuclear Vitamin D (VDR) and Estrogen (ER) Receptors in the Membrane of Muscle and Breast Cancer Cells

2003 ◽  
pp. 57-65
Author(s):  
Daniela Capiati ◽  
Graciela Santillán ◽  
Ana Rossi ◽  
Paula Monje ◽  
Ricardo Boland
Keyword(s):  
Breast Cancer ◽  
Vitamin D ◽  
Cancer Cells ◽  
Breast Cancer Cells
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