scholarly journals Metastability, an emerging concept governing BOK-mediated apoptosis initiation

Oncotarget ◽  
2018 ◽  
Vol 9 (57) ◽  
pp. 30944-30945 ◽  
Author(s):  
Tudor Moldoveanu ◽  
Janet H. Zheng
Keyword(s):  
Apoptosis Initiation

scholarly journals Real Time Analysis of Tumor Necrosis Factor-related Apoptosis-inducing Ligand/Cycloheximide-induced Caspase Activities during Apoptosis Initiation

2008 ◽  
Vol 283 (31) ◽  
pp. 21676-21685 ◽  
Author(s):  
Christian T. Hellwig ◽  
Barbara F. Kohler ◽  
Anna-Kaisa Lehtivarjo ◽  
Heiko Dussmann ◽  
Michael J. Courtney ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Real Time ◽  
Tumor Necrosis ◽  
Time Analysis ◽  
Real Time Analysis ◽  
Apoptosis Initiation ◽  
Necrosis Factor

Induction of Endoplasmic Reticulum Stress by Sonoporation: Linkage to Mitochondria-Mediated Apoptosis Initiation

2013 ◽  
Vol 39 (12) ◽  
pp. 2382-2392 ◽  
Author(s):  
Wenjing Zhong ◽  
Xian Chen ◽  
Pingping Jiang ◽  
Jennifer M.F. Wan ◽  
Peng Qin ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Apoptosis Initiation

Apoptosis initiation of β-ionone in SGC-7901 gastric carcinoma cancer cells via a PI3K-AKT pathway

2012 ◽  
Vol 87 (3) ◽  
pp. 481-490 ◽  
Author(s):  
Qian Liu ◽  
Hong-Wei Dong ◽  
Wen-Guang Sun ◽  
Ming Liu ◽  
Juan C. Ibla ◽  
...  
Keyword(s):  
Gastric Carcinoma ◽  
Cancer Cells ◽  
Akt Pathway ◽  
Apoptosis Initiation

A comparative study of U937 cell size changes during apoptosis initiation by flow cytometry, light scattering, water assay and electronic sizing

APOPTOSIS ◽  
2017 ◽  
Vol 22 (10) ◽  
pp. 1287-1295 ◽  
Author(s):  
Valentina Yurinskaya ◽  
Nikolay Aksenov ◽  
Alexey Moshkov ◽  
Michael Model ◽  
Tatyana Goryachaya ◽  
...  
Keyword(s):  
Flow Cytometry ◽  
Light Scattering ◽  
Comparative Study ◽  
Cell Size ◽  
U937 Cell ◽  
Apoptosis Initiation

scholarly journals Translational Repression of MCL-1 Couples Stress-induced eIF2α Phosphorylation to Mitochondrial Apoptosis Initiation

2007 ◽  
Vol 282 (31) ◽  
pp. 22551-22562 ◽  
Author(s):  
Ralph M. Fritsch ◽  
Günter Schneider ◽  
Dieter Saur ◽  
Melanie Scheibel ◽  
Roland M. Schmid
Keyword(s):  
Translational Repression ◽  
Mitochondrial Apoptosis ◽  
Eif2α Phosphorylation ◽  
Apoptosis Initiation

scholarly journals Bcl-2–regulated apoptosis and cytochrome c release can occur independently of both caspase-2 and caspase-9

2004 ◽  
Vol 165 (6) ◽  
pp. 775-780 ◽  
Author(s):  
Vanessa S. Marsden ◽  
Paul G. Ekert ◽  
Mark Van Delft ◽  
David L. Vaux ◽  
Jerry M. Adams ◽  
...  
Keyword(s):  
Cytochrome C ◽  
Embryonic Brain ◽  
Caspase 9 ◽  
Cytochrome C Release ◽  
Hematopoietic Development ◽  
Adult Mice ◽  
Perinatal Lethality ◽  
Caspase 2 ◽  
Apoptosis Initiation ◽  
Redundant Role

Apoptosis in response to developmental cues and stress stimuli is mediated by caspases that are regulated by the Bcl-2 protein family. Although caspases 2 and 9 have each been proposed as the apical caspase in that pathway, neither is indispensable for the apoptosis of leukocytes or fibroblasts. To investigate whether these caspases share a redundant role in apoptosis initiation, we generated caspase-2−/−9−/− mice. Their overt phenotype, embryonic brain malformation and perinatal lethality mirrored that of caspase-9−/− mice but were not exacerbated. Analysis of adult mice reconstituted with caspase-2−/−9−/− hematopoietic cells revealed that the absence of both caspases did not influence hematopoietic development. Furthermore, lymphocytes and fibroblasts lacking both remained sensitive to diverse apoptotic stimuli. Dying caspase-2−/−9−/− lymphocytes displayed multiple hallmarks of caspase-dependent apoptosis, including the release of cytochrome c from mitochondria, and their demise was antagonized by several caspase inhibitors. These findings suggest that caspases other than caspases 2 and 9 can promote cytochrome c release and initiate Bcl-2–regulated apoptosis.

scholarly journals SIRT6 knockout cells resist apoptosis initiation but not progression: a computational method to evaluate the progression of apoptosis

APOPTOSIS ◽  
2017 ◽  
Vol 22 (11) ◽  
pp. 1336-1343 ◽  
Author(s):  
Sergii Domanskyi ◽  
Justin W. Nicholatos ◽  
Joshua E. Schilling ◽  
Vladimir Privman ◽  
Sergiy Libert
Keyword(s):  
Computational Method ◽  
Apoptosis Initiation
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