scholarly journals Targeting the extradomain A of fibronectin allows identification of vascular resistance to antiangiogenic therapy in experimental glioma

Oncotarget ◽  
2018 ◽  
Vol 9 (45) ◽  
pp. 27760-27772
Author(s):  
Güliz Acker ◽  
Sophie Käthe Piper ◽  
Anna Lena Datwyler ◽  
Thomas Broggini ◽  
Irina Kremenetskaia ◽  
...  
Keyword(s):  
Vascular Resistance ◽  
Antiangiogenic Therapy ◽  
Experimental Glioma

scholarly journals EphB4 mediates resistance to antiangiogenic therapy in experimental glioma

Angiogenesis ◽  
2018 ◽  
Vol 21 (4) ◽  
pp. 873-881 ◽  
Author(s):  
Christian Uhl ◽  
Moritz Markel ◽  
Thomas Broggini ◽  
Melina Nieminen ◽  
Irina Kremenetskaia ◽  
...  
Keyword(s):  
Antiangiogenic Therapy ◽  
Experimental Glioma

Injectable Anaesthetic Agents for Cats

1992 ◽  
Vol 05 (03) ◽  
pp. 128-130
Author(s):  
Dana Allen ◽  
Doris Dyson
Keyword(s):  
Cardiac Output ◽  
Vascular Resistance ◽  
Anaesthetic Agents ◽  
Acceptable Range

Xylazine/ketamine was shown to be the most cardio-depressive anaesthetic. The fall in cardiac output, in spite of increased vascular resistance, could not maintain BP within an acceptable range. Acepromazine/ketamine and premix/thiopental are comparable and less depressive than xylazine/ketamine.

Pulmonary Vascular Versus Right Ventricular Function Changes During Targeted Therapies of Pulmonary Hypertension – An Argument for Upfront Combination Therapy?

2012 ◽  
Vol 8 (3) ◽  
pp. 209
Author(s):  
Wouter Jacobs ◽  
Anton Vonk-Noordegraaf ◽  
◽  
Keyword(s):  
Combination Therapy ◽  
Right Ventricle ◽  
Right Ventricular ◽  
Pulmonary Vascular Resistance ◽  
Vascular Resistance ◽  
Meta Analysis ◽  
Right Heart Failure ◽  
Functional Class ◽  
Pulmonary Vasculature ◽  
The Right

Pulmonary arterial hypertension is a progressive disease of the pulmonary vasculature, ultimately leading to right heart failure and death. Current treatment is aimed at targeting three different pathways: the prostacyclin, endothelin and nitric oxide pathways. These therapies improve functional class, increase exercise capacity and improve haemodynamics. In addition, data from a meta-analysis provide compelling evidence of improved survival. Despite these treatments, the outcome is still grim and the cause of death is inevitable – right ventricular failure. One explanation for this paradox of haemodynamic benefit and still worse outcome is that the right ventricle does not benefit from a modest reduction in pulmonary vascular resistance. This article describes the physiological concepts that might underlie this paradox. Based on these concepts, we argue that not only a significant reduction in pulmonary vascular resistance, but also a significant reduction in pulmonary artery pressure is required to save the right ventricle. Haemodynamic data from clinical trials hold the promise that these haemodynamic requirements might be met if upfront combination therapy is used.

Ghrelin and Obesity-An Update

2017 ◽  
Vol 9 (1) ◽  
Author(s):  
Gandhi M. ◽  
Swaminathan S.
Keyword(s):  
Diabetes Mellitus ◽  
Cardiac Output ◽  
Energy Balance ◽  
Vascular Resistance ◽  
The Body ◽  
Ghrelin Receptor ◽  
Type2 Diabetes ◽  
Type2 Diabetes Mellitus ◽  
Natural Hormones

Ghrelin as human natural hormones is involved in fundamental regulatory process of eating and energy balance. It is a stomach derived hormone that acts as at the ghrelin receptor in multiple tissues throughout to the body. Its properties includes increasing appetite, decreasing systemic inflammation, decreasing vascular resistance ,increasing cardiac output, increasing glucose and IGF-1 levels, Hence it may play a significant role in Diabetes mellitus. Many studies have linked ghrelin to obesity and this paper is an attempt to bring out recent findings on the role of ghrelin in Diabetes Mellitus, particularly type2 Diabetes mellitus.

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