scholarly journals Prognostic values of the mRNA expression of natural killer receptor ligands and their association with clinicopathological features in breast cancer patients

Oncotarget ◽  
2018 ◽  
Vol 9 (43) ◽  
pp. 27171-27196 ◽  
Author(s):  
Ali Abouelghar ◽  
Reem Hasnah ◽  
Ghina Taouk ◽  
Mohamad Saad ◽  
Manale Karam
Keyword(s):  
Breast Cancer ◽  
Mrna Expression ◽  
Natural Killer ◽  
Cancer Patients ◽  
Clinicopathological Features ◽  
Breast Cancer Patients ◽  
Receptor Ligands ◽  
Natural Killer Receptor

Clinical relevance of H-RAS, K-RAS, and N-RAS mRNA expression in primary breast cancer patients

2019 ◽  
Vol 179 (2) ◽  
pp. 403-414 ◽  
Author(s):  
Malgorzata Banys-Paluchowski ◽  
Karin Milde-Langosch ◽  
Tanja Fehm ◽  
Isabell Witzel ◽  
Leticia Oliveira-Ferrer ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Mrna Expression ◽  
Cancer Patients ◽  
Clinical Relevance ◽  
Primary Breast Cancer ◽  
Breast Cancer Patients

scholarly journals The Clinicopathological features and survival outcomes of patients with different metastatic sites in stage IV breast cancer

BMC Cancer ◽  
2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Ru Wang ◽  
Yayun Zhu ◽  
Xiaoxu Liu ◽  
Xiaoqin Liao ◽  
Jianjun He ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Brain Metastasis ◽  
Cancer Patients ◽  
Stage Iv ◽  
Clinicopathological Features ◽  
Breast Cancer Patients ◽  
Kaplan Meier ◽  
Stage Iv Breast Cancer ◽  
Multivariable Analyses ◽  
Metastatic Sites

Abstract Background The features and survival of stage IV breast cancer patients with different metastatic sites are poorly understood. This study aims to examine the clinicopathological features and survival of stage IV breast cancer patients according to different metastatic sites. Methods Using the Surveillance, Epidemiology, and End Results database, we restricted our study population to stage IV breast cancer patients diagnosed between 2010 to 2015. The clinicopathological features were examined by chi-square tests. Breast cancer-specific survival (BCSS) and overall survival (OS) were compared among patients with different metastatic sites by the Kaplan-Meier method with log-rank test. Univariable and multivariable analyses were also performed using the Cox proportional hazard model to identify statistically significant prognostic factors. Results A total of 18,322 patients were identified for survival analysis. Bone-only metastasis accounted for 39.80% of patients, followed by multiple metastasis (33.07%), lung metastasis (10.94%), liver metastasis (7.34%), other metastasis (7.34%), and brain metastasis (1.51%). The Kaplan-Meier plots showed that patients with bone metastasis had the best survival, while patients with brain metastasis had the worst survival in both BCSS and OS (p < 0.001, for both). Multivariable analyses showed that age, race, marital status, grade, tumor subtype, tumor size, surgery of primary cancer, and a history of radiotherapy or chemotherapy were independent prognostic factors. Conclusion Stage IV breast cancer patients have different clinicopathological characteristics and survival outcomes according to different metastatic sites. Patients with bone metastasis have the best prognosis, and brain metastasis is the most aggressive subgroup.

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