scholarly journals Conception, synthesis, and characterization of a rofecoxib-combretastatin hybrid drug with potent cyclooxygenase-2 (COX-2) inhibiting and microtubule disrupting activities in colon cancer cell culture and xenograft models

Oncotarget ◽  
2018 ◽  
Vol 9 (40) ◽  
pp. 26109-26129 ◽  
Author(s):  
Surendra R. Punganuru ◽  
Hanumantha Rao Madala ◽  
Constantinos M. Mikelis ◽  
Anshuman Dixit ◽  
Viswanath Arutla ◽  
...  
Keyword(s):  
Cell Culture ◽  
Colon Cancer ◽  
Cancer Cell ◽  
Colon Cancer Cell ◽  
Cyclooxygenase 2 ◽  
Synthesis And Characterization ◽  
Xenograft Models ◽  
Cox 2

The −1195G allele increases the transcriptional activity of cyclooxygenase-2 gene (COX-2) in colon cancer cell lines

2013 ◽  
Vol 53 (S1) ◽  
pp. E92-E95 ◽  
Author(s):  
Carina Pereira ◽  
Hugo Sousa ◽  
Joana Silva ◽  
Carla Brandão ◽  
Claudio Elgueta-Karstegl ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Transcriptional Activity ◽  
Cancer Cell Lines ◽  
Colon Cancer Cell ◽  
Cyclooxygenase 2 ◽  
Colon Cancer Cell Lines ◽  
Cox 2

Characterization of Gastrin-Releasing Peptide and Its Receptor Aberrantly Expressed by Human Colon Cancer Cell Lines

2000 ◽  
Vol 58 (3) ◽  
pp. 601-607 ◽  
Author(s):  
Robert E. Carroll ◽  
Denis Ostrovskiy ◽  
Sean Lee ◽  
Alexey Danilkovich ◽  
Richard V. Benya
Keyword(s):  
Colon Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Human Colon ◽  
Colon Cancer Cell ◽  
Human Colon Cancer Cell ◽  
Human Colon Cancer ◽  
Gastrin Releasing Peptide ◽  
Colon Cancer Cell Lines

scholarly journals Somatostatin inhibits colon cancer cell growth through cyclooxygenase-2 downregulation

2008 ◽  
Vol 155 (2) ◽  
pp. 198-209 ◽  
Author(s):  
R Colucci ◽  
C Blandizzi ◽  
N Ghisu ◽  
T Florio ◽  
M Del Tacca
Keyword(s):  
Colon Cancer ◽  
Cell Growth ◽  
Cancer Cell ◽  
Colon Cancer Cell ◽  
Cyclooxygenase 2 ◽  
Cancer Cell Growth

scholarly journals THE INHIBITION OF POLYISOPRENOIDS FROM NYPA FRUTICANS LEAVES ON CYCLOOXYGENASE 2 EXPRESSION OF WIDR COLON CANCER CELLS

2018 ◽  
Vol 11 (8) ◽  
pp. 154 ◽  
Author(s):  
Dini Permata Sari ◽  
Mohammad Basyuni ◽  
Poppy Anjelisa Zaitun Hasibuan ◽  
Ridha Wati
Keyword(s):  
Colon Cancer ◽  
Anticancer Activity ◽  
Cancer Cells ◽  
Colon Cancer Cell ◽  
Cyclooxygenase 2 ◽  
Colon Cancer Cells ◽  
Chemopreventive Agents ◽  
Nypa Fruticans ◽  
Diphenyltetrazolium Bromide ◽  
Cox 2

Objective: The objective of the study was to investigate the inhibitory activity of polyisoprenoids from Nypa fruticans leaves on the expression of cyclooxygenase 2 (COX-2) against colon cancer cells.Methods: Anticancer activity performed was tested by dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide method on colon cancer cell WiDr. The expression of COX-2 was observed by the immunocytochemistry method.Result: Polyisoprenoids from N. fruticans leaves exhibit anticancer activity on WiDr cells through inhibition of COX-2 expression with IC50 180.186±7.16 μg/ml.Conclusions: This study showed that polyisoprenoids from N. fruticans leaves promise chemopreventive agents for colon cancer through COX-2 inhibition.

scholarly journals Celecoxib increases retinoid sensitivity in human colon cancer cell lines

2010 ◽  
Vol 15 (3) ◽  
Author(s):  
Jian-Pei Liu ◽  
Hong-Bo Wei ◽  
Zong-Heng Zheng ◽  
Wei-Ping Guo ◽  
Jia-Feng Fang
Keyword(s):  
Colon Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Human Colon ◽  
Colon Cancer Cell ◽  
Human Colon Cancer Cell ◽  
Human Colon Cancer ◽  
Colon Cancer Cell Lines ◽  
Cox 2 ◽  
Ht 29

AbstractRetinoid resistance has limited the clinical application of retinoids as differentiation-inducing and apoptosis-inducing drugs. This study was designed to investigate whether celecoxib, a selective COX-2 inhibitor, has effects on retinoid sensitivity in human colon cancer cell lines, and to determine the possible mechanism of said effects. Cell viability was measured using the MTT assay. Apoptosis was detected via Annexin-V/PI staining and the flow cytometry assay. PGE2 production was measured with the ELISA assay. The expression of RARβ was assayed via western blotting. The results showed that celecoxib enhanced the inhibitory effect of ATRA in both COX-2 high-expressing HT-29 and COX-2 low-expressing SW480 cell lines. Further study showed the ATRA and celecoxib combination induced greater apoptosis, but that the addition of PGE2 did not affect the enhanced growth-inhibitory and apoptosis-inducing effects of the combination. Moreover, NS398 (another selective COX-2 inhibitor) did not affect the inhibitory effects of ATRA in the two cell lines. Western blotting showed that the expression of RARβ in HT-29 cell lines was increased by celecoxib, but not by NS398, and that the addition of PGE2 did not affect the celecoxib-induced expression of the retinoic acid receptor beta. In conclusion, celecoxib increased the expression of RARβ and the level of cellular ATRA sensitivity through COX-2-independent mechanisms. This finding may provide a potential strategy for combination therapy.

Sign in / Sign up

Export Citation Format

Share Document