scholarly journals High salt induces P-glycoprotein mediated treatment resistance in breast cancer cells through store operated calcium influx

Oncotarget ◽  
2018 ◽  
Vol 9 (38) ◽  
pp. 25193-25205 ◽  
Author(s):  
Duaa Babaer ◽  
Suneetha Amara ◽  
Michael Ivy ◽  
Yan Zhao ◽  
Philip E. Lammers ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Calcium Influx ◽  
Treatment Resistance ◽  
High Salt ◽  
P Glycoprotein

scholarly journals Trametenolic Acid B Reverses Multidrug Resistance in Breast Cancer Cells Through Regulating the Expression Level of P-Glycoprotein

2013 ◽  
Vol 28 (7) ◽  
pp. 1037-1044 ◽  
Author(s):  
Qiaoyin Zhang ◽  
Junzhi Wang ◽  
Haibo He ◽  
Hongbing Liu ◽  
Ximing Yan ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Multidrug Resistance ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Expression Level ◽  
P Glycoprotein

scholarly journals Sodium channel γENaC mediates IL-17 synergized high salt induced inflammatory stress in breast cancer cells

2016 ◽  
Vol 302 ◽  
pp. 1-10 ◽  
Author(s):  
Suneetha Amara ◽  
Michael T. Ivy ◽  
Elbert L. Myles ◽  
Venkataswarup Tiriveedhi
Keyword(s):  
Breast Cancer ◽  
Sodium Channel ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
High Salt ◽  
Inflammatory Stress

scholarly journals Compressive Stress Enhances Invasive Phenotype of Breast Cancer Cells via Piezo1 Activation

2019 ◽  
Author(s):  
Mingzhi Luo ◽  
Kenneth KY Ho ◽  
Zhaowen Tong ◽  
Linhong Deng ◽  
Allen Liu
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Compressive Stress ◽  
Breast Cancer Cells ◽  
Cancer Metastasis ◽  
Calcium Influx ◽  
Breast Cancer Metastasis ◽  
Matrix Degradation ◽  
Apical Side ◽  
Actin Protrusions

Abstract Uncontrolled growth in solid tumor generates compressive stress that drives cancer cells into invasive phenotypes, but little is known about how such stress affects the invasion and matrix degradation of cancer cells and the underlying mechanisms. Here we show that compressive stress enhanced invasion and matrix degradation of breast cancer cells. We further identified Piezo1 as the putative mechanosensitive cellular component that transmits compressive stress to induce calcium influx, which in turn activate Src/ERK signaling. Interestingly, we observed actin protrusions with matrix degradation ability on the apical side of the cells. Furthermore, we demonstrate that Piezo1 channels were partially localized in caveolae, and reduction of caveolin-1 expression or disruption of caveolae with methyl-β-cyclodextrin led to not only reduced Piezo1 expression but also attenuation of the invasive phenotypes promoted by compressive stress. Taken together, our data indicate that mechanical compressive stress activates Piezo1 channels to mediate enhanced cancer cell invasion and matrix degradation that may be a critical mechanotransduction pathway during, and potentially a novel therapeutic target for, breast cancer metastasis.

scholarly journals Suppression of αvβ6 downregulates P-glycoprotein and sensitizes multidrug-resistant breast cancer cells to anticancer drugs

Neoplasma ◽  
2020 ◽  
Vol 67 (02) ◽  
pp. 379-388 ◽  
Author(s):  
Y.H. ZHANG ◽  
Z.F. GAO ◽  
G.H. DONG ◽  
X. LI ◽  
Y. WU ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Anticancer Drugs ◽  
Breast Cancer Cells ◽  
Multidrug Resistant ◽  
P Glycoprotein
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