scholarly journals Histology-dependent prognostic role of pERK and p53 protein levels in early-stage non-small cell lung cancer

Oncotarget ◽  
2018 ◽  
Vol 9 (28) ◽  
pp. 19945-19960 ◽  
Author(s):  
Álvaro Quintanal-Villalonga ◽  
Mariló Mediano ◽  
Irene Ferrer ◽  
Ricardo Meléndez ◽  
Andrés Carranza-Carranza ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Early Stage ◽  
P53 Protein ◽  
Small Cell ◽  
Small Cell Lung ◽  
Prognostic Role ◽  
Protein Levels

scholarly journals Prognostic role of FGFR1 amplification in early-stage non-small cell lung cancer

2014 ◽  
Vol 110 (12) ◽  
pp. 2914-2922 ◽  
Author(s):  
N Cihoric ◽  
S Savic ◽  
S Schneider ◽  
I Ackermann ◽  
M Bichsel-Naef ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Early Stage ◽  
Small Cell ◽  
Small Cell Lung ◽  
Prognostic Role

scholarly journals Prognostic Role of miR-205 in Early-Stage (T1N0) Non-Small Cell Lung Cancer

2014 ◽  
Vol 03 (02) ◽  
pp. 45-51 ◽  
Author(s):  
Laura Boldrini ◽  
Mirella Giordano ◽  
Adele Servadio ◽  
Greta Alì ◽  
Alice Cocco ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Early Stage ◽  
Small Cell ◽  
Small Cell Lung ◽  
Prognostic Role

scholarly journals Prognostic Role of Circulating miRNAs in Early-Stage Non-Small Cell Lung Cancer

2019 ◽  
Vol 8 (2) ◽  
pp. 131 ◽  
Author(s):  
Paola Ulivi ◽  
Elisabetta Petracci ◽  
Giorgia Marisi ◽  
Sara Baglivo ◽  
Rita Chiari ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Early Stage ◽  
Small Cell ◽  
Disease Stage ◽  
Small Cell Lung ◽  
Prognostic Role ◽  
Early Stage Nsclc

Non-small cell lung cancer (NSCLC) is the primary cause of cancer-related death worldwide, with a low 5-year survival rate even in fully resected early-stage disease. Novel biomarkers to identify patients at higher risk of relapse are needed. We studied the prognostic value of 84 circulating microRNAs (miRNAs) in 182 patients with resected early-stage NSCLC (99 adenocarcinoma (ADC), 83 squamous cell carcinoma (SCC)) from whom peripheral blood samples were collected pre-surgery. miRNA expression was analyzed in relation to disease-free survival (DFS) and overall survival (OS). In univariable analyses, five miRNAs (miR-26a-5p, miR-126-3p, miR-130b-3p, miR-205-5p, and miR-21-5p) were significantly associated with DFS in SCC, and four (miR-130b-3p, miR-26a-5p, miR-126-3p, and miR-205-5p) remained significantly associated with OS. In ADC, miR-222-3p, miR-22-3p, and mir-93-5p were significantly associated with DFS, miR-22-3p remaining significant for OS. Given the high-dimensionality of the dataset, multivariable models were obtained using a regularized Cox regression including all miRNAs and clinical covariates. After adjustment for disease stage, only miR-126-3p showed an independent prognostic role, with higher values associated with longer DFS in SCC patients. With regard to ADC and OS, no miRNA remained significant in multivariable analysis. Further investigation into the role of miR-126 as a prognostic marker in early-stage NSCLC is warranted.

scholarly journals Prognostic role of TPL2 in early-stage non-small cell lung cancer

2017 ◽  
Vol 15 (6) ◽  
pp. 3451-3458 ◽  
Author(s):  
Laura Boldrini ◽  
Mirella Giordano ◽  
Adele Servadio ◽  
Cristina Niccoli ◽  
Pietro Bertoglio ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Early Stage ◽  
Small Cell ◽  
Small Cell Lung ◽  
Prognostic Role

scholarly journals Prognostic role of circulating tumor cells in patients with EGFR -mutated or ALK -rearranged non-small cell lung cancer

2018 ◽  
Vol 9 (5) ◽  
pp. 640-645 ◽  
Author(s):  
Bing Tong ◽  
Yan Xu ◽  
Jing Zhao ◽  
Minjiang Chen ◽  
Wei Zhong ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung ◽  
Prognostic Role ◽  
Egfr Mutated

scholarly journals The Diagnostic Role of Sputum miRNA in Non-Small Cell Lung Cancer

2020 ◽  
Author(s):  
Zaoxiu Hu ◽  
Yonghe Zhao ◽  
Yanlong Yang ◽  
Zhenghai Shen ◽  
Yunchao Huang
Keyword(s):  
Lung Cancer ◽  
Diagnostic Accuracy ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Early Stage ◽  
Small Cell ◽  
Stage I ◽  
Small Cell Lung ◽  
Diagnostic Role

Abstract Objective: Recent studies indicated sputum miRNAs may provide a promising approach for non-small cell lung cancer (NSCLC) diagnosis. But some results were still inconsistent. So, we performed meta-analysis to evaluate the diagnostic role of sputum miRNAs for the detection of NSCLC.Methods: Eligible studies that estimated the diagnostic accuracy of sputum miRNAs in NSCLC were searched in Pubmed, Embase and Web of Science and Chinese National Knowledge Infrastructure (CNKI). Data from the eligible studies were collected and pooled; sensitivity, specificity, positive and negative likelihood ratios, diagnostic odds ratios, weighted symmetric summary ROC curve and the area under the curve (AUC) were calculated by bi-variate random effects model. The between-study heterogeneity was evaluated by Q test and I2 statistics.Results: 30 studies from 16 articles were included for analysis. The overall analysis yielded the sensitivity of 0.77 (95% CI: 0.73–0.81) and specificity of 0.87 (95% CI: 0.83–0.90), with an area under the SROC curve (AUC) of 0.89 (95% CI: 0.86–0.91). Subgroup analysis revealed the diagnostic accuracy in multiple miRNAs studies was higher than single miRNA (the sensitivity, specifcity and an AUC of multiple miRNAs were 0.76, 0.88 and 0.90; and for single miRNA, it was 0.74, 0.74, and 0.80). The diagnostic performance in early stage NSCLC was also very high (the sensitivity, specifcity and an AUC of stage I/II was 0.76, 0.88 and 0.91; and for stage I, it was 0.79, 0.85, and 0.87). We also found miR-210, miR-21, miR-31 and miR-126-3p might serve as potential biomarkers for lung cancer.Conclusion: Sputum miRNAs was useful noninvasive biomarkers for NSCLC diagnosis.

scholarly journals Prognostic Role of MicroRNA-21 in Non-small Cell Lung Cancer: a Meta-analysis

2012 ◽  
Vol 13 (5) ◽  
pp. 2329-2334 ◽  
Author(s):  
Xue-Lei Ma ◽  
Lei Liu ◽  
Xiao-Xiao Liu ◽  
Yun Li ◽  
Lei Deng ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Meta Analysis ◽  
Small Cell ◽  
Small Cell Lung ◽  
Prognostic Role
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