scholarly journals Long noncoding RNAs are associated with metabolic and cellular processes in the jejunum mucosa of pre-weaning calves in response to different diets

Oncotarget ◽  
2018 ◽  
Vol 9 (30) ◽  
pp. 21052-21069 ◽  
Author(s):  
Rosemarie Weikard ◽  
Frieder Hadlich ◽  
Harald M. Hammon ◽  
Doerte Frieten ◽  
Caroline Gerbert ◽  
...  
Keyword(s):  
Noncoding Rnas ◽  
Long Noncoding Rnas ◽  
Cellular Processes

scholarly journals The Role of lncRNA in the Development of Tumors, Including Breast Cancer

2021 ◽  
Vol 22 (16) ◽  
pp. 8427
Author(s):  
Beata Smolarz ◽  
Anna Zadrożna-Nowak ◽  
Hanna Romanowicz
Keyword(s):  
Breast Cancer ◽  
Breast Carcinoma ◽  
Present Article ◽  
Noncoding Rnas ◽  
Long Noncoding Rnas ◽  
Regulation Of Transcription ◽  
Ribonucleic Acids ◽  
Detailed Review ◽  
Cellular Processes

Long noncoding RNAs (lncRNAs) are the largest groups of ribonucleic acids, but, despite the increasing amount of literature data, the least understood. Given the involvement of lncRNA in basic cellular processes, especially in the regulation of transcription, the role of these noncoding molecules seems to be of great importance for the proper functioning of the organism. Studies have shown a relationship between disturbed lncRNA expression and the pathogenesis of many diseases, including cancer. The present article presents a detailed review of the latest reports and data regarding the importance of lncRNA in the development of cancers, including breast carcinoma.

scholarly journals Long Noncoding RNA Plays a Key Role in Metastasis and Prognosis of Hepatocellular Carcinoma

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Guangbing Li ◽  
Haohai Zhang ◽  
Xueshuai Wan ◽  
Xiaobo Yang ◽  
Chengpei Zhu ◽  
...  
Keyword(s):  
Gene Expression ◽  
Hepatocellular Carcinoma ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Regulation Of Gene Expression ◽  
Noncoding Rnas ◽  
Long Noncoding Rnas ◽  
Comprehensive Review ◽  
Cellular Processes

Long noncoding RNAs (lncRNAs) have been attracting immense research interests. However, only a handful of lncRNAs had been thoroughly characterized. They were involved in fundamental cellular processes including regulation of gene expression at epigenetics as well as tumorogenesis. In this paper, we give a systematic and comprehensive review of existing literature about lncRNA involvement in hepatocellular carcinoma. This review exhibited that lncRNAs played important roles in tumorigenesis and subsequent prognosis and metastasis of hepatocellular carcinoma and elucidated the role of some specific lncRNAs such as MALAT1 and HOTAIR in the pathophysiology of hepatocellular carcinoma and their potential of being therapeutic targets.

scholarly journals Long Noncoding RNAs as a Key Player in Hepatocellular Carcinoma

2017 ◽  
Vol 9 ◽  
pp. 1179299X1773730 ◽  
Author(s):  
Mrigaya Mehra ◽  
Ranjit Chauhan
Keyword(s):  
Hepatocellular Carcinoma ◽  
Molecular Mechanisms ◽  
Structural Integrity ◽  
Gene Expression Regulation ◽  
Noncoding Rnas ◽  
Clinical Applications ◽  
Long Noncoding Rnas ◽  
Protein Coding ◽  
Cellular Processes ◽  
The World

Hepatocellular carcinoma (HCC) is a major malignancy in the liver and has emerged as one of the main cancers in the world with a high mortality rate. However, the molecular mechanisms of HCC are still poorly understood. Long noncoding RNAs (lncRNAs) have recently come to the forefront as functional non–protein-coding RNAs that are involved in a variety of cellular processes ranging from maintaining the structural integrity of chromosomes to gene expression regulation in a spatiotemporal manner. Many recent studies have reported the involvement of lncRNAs in HCC which has led to a better understanding of the underlying molecular mechanisms operating in HCC. Long noncoding RNAs have been shown to regulate development and progression of HCC, and thus, lncRNAs have both diagnostic and therapeutic potentials. In this review, we present an overview of the lncRNAs involved in different stages of HCC and their potential in clinical applications which have been studied so far.

scholarly journals Identification and Characterization of Long Noncoding RNAs in Ovine Skeletal Muscle

Animals ◽  
2018 ◽  
Vol 8 (7) ◽  
pp. 127
Author(s):  
Qing Li ◽  
Ruizao Liu ◽  
Huijing Zhao ◽  
Ran Di ◽  
Zengkui Lu ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Gastrocnemius Muscle ◽  
Muscle Development ◽  
Noncoding Rnas ◽  
Long Noncoding Rnas ◽  
Differentially Expressed ◽  
Pairwise Comparisons ◽  
Cellular Processes ◽  
Identification And Characterization

Long noncoding RNAs (lncRNAs) are increasingly being recognized as key regulators in many cellular processes. However, few reports of them in livestock have been published. Here, we describe the identification and characterization of lncRNAs in ovine skeletal muscle. Eight libraries were constructed from the gastrocnemius muscle of fetal (days 85 and 120), newborn and adult Texel and Ujumqin sheep. The 2002 identified transcripts shared some characteristics, such as their number of exons, length and distribution. We also identified some coding genes near these lncRNA transcripts, which are particularly associated with transcriptional regulation- and development-related processes, suggesting that the lncRNAs are associated with muscle development. In addition, in pairwise comparisons between the libraries of the same stage in different breeds, a total of 967 transcripts were differentially expressed but just 15 differentially expressed lncRNAs were common to all stages. Among them, we found that TCONS_00013201 exhibited higher expression in Ujumqin samples, while TCONS_00006187 and TCONS_00083104 were higher in Texel samples. Moreover, TCONS_00044801, TCONS_00008482 and TCONS_00102859 were almost completely absent from Ujumqin samples. Our results suggest that differences in the expression of these lncRNAs may be associated with the muscular differences observed between Texel and Ujumqin sheep breeds.

scholarly journals Long noncoding RNAs in key cellular processes involved in aortic aneurysms

2020 ◽  
Vol 292 ◽  
pp. 112-118 ◽  
Author(s):  
Zhi-yuan Wu ◽  
Matthias Trenner ◽  
Reinier A. Boon ◽  
Joshua M. Spin ◽  
Lars Maegdefessel
Keyword(s):  
Noncoding Rnas ◽  
Aortic Aneurysms ◽  
Long Noncoding Rnas ◽  
Cellular Processes

Long noncoding RNAs: lincs between human health and disease

2017 ◽  
Vol 45 (3) ◽  
pp. 805-812 ◽  
Author(s):  
Zhi Hao Kwok ◽  
Yvonne Tay
Keyword(s):  
Cancer Biology ◽  
High Throughput Sequencing ◽  
Current Knowledge ◽  
Noncoding Rnas ◽  
Clinical Applications ◽  
Long Noncoding Rnas ◽  
Cellular Processes ◽  
Health And Disease ◽  
Underlying Mechanisms ◽  
Sequencing Platforms

Long noncoding RNAs (lncRNAs) represent one of the largest classes of transcripts and are highly diverse in terms of characteristics and functions. Advances in high-throughput sequencing platforms have enabled the rapid discovery and identification of lncRNAs as key regulatory molecules involved in various cellular processes and their dysregulation in various human diseases. Here, we summarize the current knowledge of the functions and underlying mechanisms of lncRNA activity with a particular focus on cancer biology. We also discuss the potential of lncRNAs as diagnostic and therapeutic targets for clinical applications.

scholarly journals Long Noncoding RNAs and Stress Response in the Nucleolus

Cells ◽  
2019 ◽  
Vol 8 (7) ◽  
pp. 668 ◽  
Author(s):  
Sergei A. Pirogov ◽  
Vladimir A. Gvozdev ◽  
Mikhail S. Klenov
Keyword(s):  
Stress Response ◽  
Ribosomal Rna ◽  
Noncoding Rnas ◽  
Long Noncoding Rnas ◽  
Environmental Stressors ◽  
Rrna Synthesis ◽  
Stress Adaptation ◽  
Physiological Conditions ◽  
Cellular Processes

Long noncoding RNAs (lncRNAs) perform diverse functions in the regulation of cellular processes. Here we consider a variety of lncRNAs found in the ribosome production center, the nucleolus, and focus on their role in the response to environmental stressors. Nucleolar lncRNAs ensure stress adaptation by cessation of resource-intensive ribosomal RNA (rRNA) synthesis and by inducing the massive sequestration of proteins within the nucleolus. Different cell states like quiescence and cancer are also controlled by specific lncRNAs in the nucleolus. Taken together, recent findings allow us to consider lncRNAs as multifunctional regulators of nucleolar activities, which are responsive to various physiological conditions.

scholarly journals Long Noncoding RNAs in Metabolic Syndrome Related Disorders

2016 ◽  
Vol 2016 ◽  
pp. 1-12 ◽  
Author(s):  
Magdalena Losko ◽  
Jerzy Kotlinowski ◽  
Jolanta Jura
Keyword(s):  
Metabolic Syndrome ◽  
Noncoding Rna ◽  
Noncoding Rnas ◽  
Long Noncoding Rnas ◽  
Small Nuclear Rna ◽  
Rna Sequences ◽  
Ribonucleic Acids ◽  
Transcript Stability ◽  
Cellular Processes ◽  
Nucleolar Rna

Ribonucleic acids (RNAs) are very complex and their all functions have yet to be fully clarified. Noncoding genes (noncoding RNA, sequences, and pseudogenes) comprise 67% of all genes and they are represented by housekeeping noncoding RNAs (transfer RNA (tRNA), ribosomal RNA (rRNA), small nuclear RNA (snRNA), and small nucleolar RNA (snoRNA)) that are engaged in basic cellular processes and by regulatory noncoding RNA (short and long noncoding RNA (ncRNA)) that are important for gene expression/transcript stability. In this review, we summarize data concerning the significance of long noncoding RNAs (lncRNAs) in metabolic syndrome related disorders, focusing on adipose tissue and pancreatic islands.

Dysregulated Expression of Long Noncoding RNAs in Endometriosis

2019 ◽  
Vol 29 (2) ◽  
pp. 113-121 ◽  
Author(s):  
Xue-ying Zhang ◽  
Lian-wen Zheng ◽  
Chun-jin Li ◽  
Ying Xu ◽  
Xu Zhou ◽  
...  
Keyword(s):  
Noncoding Rnas ◽  
Long Noncoding Rnas
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