scholarly journals Tissue miRNA 483-3p expression predicts tumor recurrence after surgical resection in histologically advanced hepatocellular carcinomas

Oncotarget ◽  
2018 ◽  
Vol 9 (25) ◽  
pp. 17895-17905 ◽  
Author(s):  
Francesco Vasuri ◽  
Silvia Fittipaldi ◽  
Vanessa De Pace ◽  
Laura Gramantieri ◽  
Valentina Bertuzzo ◽  
...  
Keyword(s):  
Surgical Resection ◽  
Tumor Recurrence ◽  
Hepatocellular Carcinomas

scholarly journals Is the Rationale of Anatomical Liver Resection for Hepatocellular Carcinoma Universally Adoptable? A Hypothesis-Driven Review

Medicina ◽  
2021 ◽  
Vol 57 (2) ◽  
pp. 131
Author(s):  
Young-Jen Lin ◽  
Cheng-Maw Ho
Keyword(s):  
Hepatocellular Carcinoma ◽  
Tumor Microenvironment ◽  
Surgical Resection ◽  
Tumor Recurrence ◽  
Hepatic Metastases ◽  
Vascular Supply ◽  
Tumor Ablation ◽  
Supporting Evidence ◽  
En Bloc ◽  
Margin Width

Surgical resection is the first-line curative treatment modality for resectable hepatocellular carcinoma (HCC). Anatomical resection (AR), described as systematic removal of a liver segment confined by tumor-bearing portal tributaries, may improve survival by reducing the risk of tumor recurrence compared with non-AR. In this article, we propose the rationale for AR and its universal adoption by providing supporting evidence from the advanced understanding of a tumor microenvironment and accumulating clinical experiences of locoregional tumor ablation therapeutics. AR may be advantageous because it completely removes the en-bloc by interrupting tumor vascular supply and thus extirpates the spreading of tumor microthrombi, if they ever exist, within the supplying portal vein. However, HCC is a hypervascular tumor that can promote neoangiogenesis in the local tumor microenvironment, which in itself can break through the anatomical boundary within the liver and even retrieve nourishment from extrahepatic vessels, such as inferior phrenic or omental arteries. Additionally, increasing clinical evidence for locoregional tumor ablation therapies, such as radiofrequency ablation, predominantly performed as a non-anatomical approach, suggests comparable outcomes for surgical resection, particularly in small HCC and colorectal, hepatic metastases. Moreover, liver transplantation for HCC, which can be considered as AR of the whole liver followed by implantation of a new graft, is not universally free from post-transplant tumor recurrence. Overall, AR should not be considered the gold standard among all surgical resection methods. Surgical resection is fundamentally reliant on choosing the optimal margin width to achieve en-bloc tumor niche removal while balancing between oncological radicality and the preservation of postoperative liver function. The importance of this is to liberate surgical resilience in hepatocellular carcinoma. The overall success of HCC treatment is determined by the clearance of the theoretical niche. Developing biomolecular-guided navigation device/technologies may provide surgical guidance toward the total removal of microscopic tumor niche to achieve superior oncological outcomes.

scholarly journals Comprehensive Treatment of Mediastinal Neuroendocrine Tumor: A Case Report

2021 ◽  
Author(s):  
Qi Yu ◽  
Zhen Li ◽  
Xinwei Han
Keyword(s):  
Case Report ◽  
Neuroendocrine Tumor ◽  
Surgical Resection ◽  
Neuroendocrine Tumors ◽  
Tumor Recurrence ◽  
Transcatheter Arterial Chemoembolization ◽  
Comprehensive Treatment ◽  
Drug Eluting ◽  
Arterial Chemoembolization

Abstract Neuroendocrine tumors in the mediastinum are relatively rare. We report a patient with mediastinal neuroendocrine tumor that was successfully resected after descending stage by drug-eluting embolic transcatheter arterial chemoembolization had been performed. No tumor recurrence was found in the 1-year follow-up after surgical resection.

Usefulness of MMP-9/TIMP-1 in Predicting Tumor Recurrence in Patients Undergoing Curative Surgical Resection for Gastric Carcinoma

2007 ◽  
Vol 52 (3) ◽  
pp. 753-759 ◽  
Author(s):  
Yeon Seok Seo ◽  
Jong-Jae Park ◽  
Ji Hoon Kim ◽  
Jin Yong Kim ◽  
Jong Eun Yeon ◽  
...  
Keyword(s):  
Gastric Carcinoma ◽  
Surgical Resection ◽  
Tumor Recurrence

scholarly journals 3D MR Elastography of Hepatocellular Carcinomas as a Potential Biomarker for Predicting Tumor Recurrence

2018 ◽  
Vol 49 (3) ◽  
pp. 719-730 ◽  
Author(s):  
Jin Wang ◽  
Qungang Shan ◽  
Yong Liu ◽  
Hao Yang ◽  
Sichi Kuang ◽  
...  
Keyword(s):  
Tumor Recurrence ◽  
Mr Elastography ◽  
Hepatocellular Carcinomas ◽  
Potential Biomarker

EpCAM as a Predictive Marker of Tumor Recurrence and Survival in Patients Who Underwent Surgical Resection for Hepatocellular Carcinoma

2018 ◽  
Vol 38 (7) ◽  
pp. 4101-4109 ◽  
Author(s):  
CHOONG-KYUN NOH ◽  
HEE JEONG WANG ◽  
CHANG MIN KIM ◽  
JINPYO KIM ◽  
SO YOUNG YOON ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Surgical Resection ◽  
Tumor Recurrence ◽  
Predictive Marker

scholarly journals Surgical Resection and Pazopanib Treatment for Recurrent Cardiac Angiosarcoma

2019 ◽  
Vol 12 ◽  
pp. 2632010X1983126
Author(s):  
Yuki Nakamura ◽  
Koichi Toda ◽  
Shigeru Miyagawa ◽  
Yasushi Yoshikawa ◽  
Hiroki Hata ◽  
...  
Keyword(s):  
Surgical Resection ◽  
Poor Prognosis ◽  
Tumor Recurrence ◽  
Kinase Inhibitor ◽  
Patient Survival ◽  
Optimal Management ◽  
Improve Patient Survival ◽  
Cardiac Angiosarcoma ◽  
Sarcoma Treatment ◽  
Improve Patient

Cardiac sarcoma treatment is challenging for surgeons because of frequent tumor recurrence and poor prognosis. In addition, optimal management of recurrences is not well established. The multi-targeted tyrosine kinase inhibitor, pazopanib, was recently approved for soft-tissue sarcoma. Herein, we present a case involving recurrent cardiac angiosarcoma where the patient survived for 2 years with complete remission of disease after repeated surgical resection and treatment with oral pazopanib. Based on our experience, aggressive surgical resection combined with pazopanib may be a valid treatment for recurrent cardiac angiosarcoma to improve patient survival.

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