scholarly journals Locally advanced cervical cancer with bladder invasion: clinical outcomes and predictive factors for vesicovaginal fistulae

Oncotarget ◽  
2018 ◽  
Vol 9 (10) ◽  
pp. 9299-9310 ◽  
Author(s):  
Roger Sun ◽  
Ines Koubaa ◽  
Elaine Johanna Limkin ◽  
Isabelle Dumas ◽  
Enrica Bentivegna ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Clinical Outcomes ◽  
Predictive Factors ◽  
Locally Advanced ◽  
Advanced Cervical Cancer ◽  
Locally Advanced Cervical Cancer ◽  
Vesicovaginal Fistulae ◽  
Bladder Invasion

scholarly journals Carbon-ion radiotherapy for locally advanced cervical cancer with bladder invasion

2016 ◽  
Vol 57 (6) ◽  
pp. 684-690 ◽  
Author(s):  
Shintaro Shiba ◽  
Masaru Wakatsuki ◽  
Shingo Kato ◽  
Tatsuya Ohno ◽  
Noriyuki Okonogi ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Survival Rate ◽  
Local Control ◽  
Locally Advanced ◽  
Carbon Ion Radiotherapy ◽  
Therapeutic Effects ◽  
Advanced Cervical Cancer ◽  
Carbon Ion ◽  
Locally Advanced Cervical Cancer ◽  
Bladder Invasion

Abstract The purpose of this study was to evaluate the efficacy and toxicities of carbon-ion radiotherapy (C-ion RT) for locally advanced cervical cancer with bladder invasion by a subset analysis of pooled data from eight prospective clinical trials at the National Institute of Radiological Sciences. Between June 1995 and January 2014, 29 patients with locally advanced cervical cancer with bladder invasion were identified. The median age was 56 years old (range 31–79 years old). The median tumor size at diagnosis on magnetic resonance imaging was 6.7 cm (range 3.5–11.0 cm). Histologically, 20 patients had squamous cell carcinoma and 9 had adenocarcinoma. C-ion RT was performed as a dose-escalation study in the initial trials. All patients received prophylactic whole-pelvic or extended-field irradiation and local boost. The total dose to the cervical tumor was 52.8–74.4 Gy (relative biological effectiveness) in 20 or 24 fractions. Weekly cisplatin (40 mg/m2/week, five cycles) was concurrently given to four patients. The median follow-up of all patients was 28.6 months (range 8.8–238.6 months). Grade 2 or higher late complications in the bladder were observed in eight patients, with seven developing vesicovaginal fistula. Six patients had Grade 2 or higher complications in the rectosigmoid colon. The 3-year overall survival rate was 47%, the 3-year local control rate was 66%, and the 3-year disease-free survival rate was 28%. In this study, C-ion RT showed favorable local control with reasonable toxicities, but the results were still unsatisfactory. We have the expectation of improvement of therapeutic effects by using C-ion RT with concurrent chemotherapy.

Laparoscopy-Assisted Transvaginal Total Exenteration for Locally Advanced Cervical Cancer with Bladder Invasion after Radiotherapy

2004 ◽  
Vol 18 (9) ◽  
pp. 867-870 ◽  
Author(s):  
Meng-Yeh Lin ◽  
Eric W. Fan ◽  
Allen W. Chiu ◽  
Yu-Feng Tian ◽  
Ming-Ping Wu ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Locally Advanced ◽  
Advanced Cervical Cancer ◽  
Locally Advanced Cervical Cancer ◽  
Bladder Invasion
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