scholarly journals Significant association between interleukin-10 gene polymorphisms and cervical cancer risk: a meta-analysis

Oncotarget ◽  
2018 ◽  
Vol 9 (15) ◽  
pp. 12365-12375 ◽  
Author(s):  
Chong Guo ◽  
Li Wen ◽  
Ju-Kun Song ◽  
Weng-Jing Zeng ◽  
Chao Dan ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cancer Risk ◽  
Gene Polymorphisms ◽  
Meta Analysis ◽  
Interleukin 10 ◽  
Cervical Cancer Risk

scholarly journals Association between HLA-DP Gene Polymorphisms and Cervical Cancer Risk: A Meta-Analysis

2018 ◽  
Vol 2018 ◽  
pp. 1-13 ◽  
Author(s):  
Lin Cheng ◽  
Yan Guo ◽  
Shipeng Zhan ◽  
Peiyuan Xia
Keyword(s):  
Cervical Cancer ◽  
Cancer Risk ◽  
Gene Polymorphisms ◽  
Meta Analysis ◽  
Human Leukocyte ◽  
Cervical Cancer Risk ◽  
Leukocyte Antigens ◽  
Knowledge Infrastructure ◽  
Increased Risk ◽  
The Relationship

Objective. We aimed to derive a more precise estimation of the associations between human leukocyte antigens DP (HLA-DP) gene polymorphisms and cervical cancer risk by meta-analysis. Methods. PubMed, EMBASE, ScienceDirect, Web of Science, Chinese National Knowledge Infrastructure (CNKI), and Wanfang databases were systematically searched to identify studies investigating the relationship between HLA-DP gene polymorphisms and cervical cancer. The associations between them were evaluated by pooled OR and 95% CI. Results. A total of 11 studies including 5008 cases and 9322 controls with 11 HLA-DP alleles were included in the current meta-analysis. Results. The results showed that HLA-DPB1⁎03:01 was significantly associated with an increased risk of cervical cancer (OR=1.252, 95%CI: 1.116-1.403, Pz=0.001), while HLA-DPB1⁎04:02 and HLA-DP rs3117027 G allele were significantly associated with a decreased risk of cervical cancer (OR=0.744, 95%CI: 0.652-0.848, Pz=0.001; OR=0.790, 95%CI: 0.745-0.837, Pz=0.001), and HLA-DP rs9277535 G allele was significantly associated with a decreased risk of cervical cancer in Asia (OR=0.802, 95%CI: 0.753-0.855, Pz=0.001). Subgroup analyses based on race system showed that HLA-DPB1⁎13:01 was significantly associated with an increased risk of cervical cancer in Asia (OR=1.834, 95%CI: 1.107-3.039, Pz=0.019). No significant association was established for the HLA-DP following alleles: DPB1⁎02:01, DPB1⁎02:02, DPB1⁎04:01, DPB1⁎05:01, rs4282438, and rs3077. Conclusion. HLA-DP gene polymorphisms (HLA-DPB1⁎03:01, DPB1⁎04:02, DPB1⁎13:01, rs9277535, and rs3117027) were significantly associated with cervical cancer.

Interleukin 1β and Interleukin 1 Receptor Antagonist Gene Polymorphisms and Cervical Cancer: A Meta-analysis

2014 ◽  
Vol 24 (6) ◽  
pp. 984-990 ◽  
Author(s):  
Shimu Wu ◽  
Guiping Hu ◽  
Jun Chen ◽  
Guangyun Xie
Keyword(s):  
Cervical Cancer ◽  
Cancer Risk ◽  
Receptor Antagonist ◽  
Publication Bias ◽  
Gene Polymorphisms ◽  
Meta Analysis ◽  
Interleukin 1 ◽  
Interleukin 1Β ◽  
Cervical Cancer Risk ◽  
Increased Risk

ObjectivesPrevious studies investigating the association between interleukin 1β (IL-1β) and its receptor antagonist (IL-1RN) polymorphism and cervical cancer risk have reported controversial results. Thus, we examined these associations by performing meta-analyses.Methods and MaterialsFourteen studies testing the association between IL-1β and/or IL-1RN gene polymorphisms and cervical cancer were examined: 5 studies of IL-1β–511C/T, 3 studies of IL-1β–31T/C, and 6 studies of IL-1RN. Overall and ethnicity-specific summary odds ratios (ORs) and corresponding 95% confidence intervals (CIs) for cervical cancer associated with these polymorphisms were estimated using fixed- and random-effects models. Heterogeneity and publication bias were evaluated.ResultsMeta-analysis of all 6 studies showed variant genotypes of IL-1RN to be associated with an elevated cervical cancer risk (RN2/RN2 vs RN1/RN1: OR, 2.64; 95% CI, 1.29–5.40; recessive: OR, 2.15; 95% CI, 1.06–4.38; dominant: OR, 1.60; 95% CI, 1.07–2.38). Combined analysis indicated that IL-1β–511C/T polymorphism was also associated with increased risk of cervical cancer (TT vs CC: OR, 1.56; 95% CI, 1.22–1.99; CT vs CC: OR, 1.61; 95% CI, 1.31–1.99; dominant: OR, 1.60; 95% CI, 1.31–1.95). No significant association of IL-1β–31T/C and cervical cancer risk was detected. There was no evidence of publication bias.ConclusionsThis meta-analysis suggested that the IL-1RN and IL-1β–511C/T polymorphisms may contribute to genetic susceptibility of cervical cancer. More studies are needed to further evaluate the role of the IL-1β–31T/C polymorphism in the etiology of cancer.

The HLA-DQB1 gene polymorphisms associated with cervical cancer risk: A meta-analysis

2015 ◽  
Vol 73 ◽  
pp. 58-64 ◽  
Author(s):  
Xiaojing Zhang ◽  
Zunfu Lv ◽  
Hua Yu ◽  
Fangfang Wang ◽  
Jianqing Zhu
Keyword(s):  
Cervical Cancer ◽  
Cancer Risk ◽  
Gene Polymorphisms ◽  
Meta Analysis ◽  
Cervical Cancer Risk ◽  
Dqb1 Gene

Interleukin 10 Polymorphisms and Cervical Cancer Risk: A Meta-Analysis

2013 ◽  
Vol 23 (1) ◽  
pp. 126-133 ◽  
Author(s):  
Jing Ni ◽  
Yang Ye ◽  
Fang Teng ◽  
Qiang Wu
Keyword(s):  
Cervical Cancer ◽  
Cancer Risk ◽  
Fixed Effects ◽  
Cancer Susceptibility ◽  
Meta Analysis ◽  
Interleukin 10 ◽  
Random Effects Models ◽  
Weinberg Equilibrium ◽  
Cervical Cancer Risk ◽  
Hardy Weinberg Equilibrium

BackgroundA debate exists about whether interleukin 10 (IL-10) polymorphisms (IL-10−1082G/A and IL-10−592C/A) confer additional risk for cervical cancer. To derive a more precise estimation of the relationship between IL-10 polymorphisms and cervical cancer risk, we conducted a meta-analysis of all available studies relating the −1082G/A and −592C/A polymorphisms of the IL-10 gene to the risk of developing cervical cancer.MethodsEight studies were eligible for IL-10 −1082G/A (1498 cases and 1608 controls), and 5 studies were eligible for IL-10 −592C/A (2396 cases and 1388 controls). Pooled odds ratios (ORs) were appropriately derived from fixed-effects or random-effects models. Subgroup analyses were performed by ethnicity and Hardy-Weinberg equilibrium in the controls.ResultsIn the overall analysis, no significant association between the IL-10−1082G/A polymorphism and the risk of cervical cancer was observed. In the subgroup analysis by ethnicity, IL-10 −1082A allele was associated with decreased cervical cancer susceptibility among whites (A vs G: OR, 0.39; 95% confidence interval [CI], 0.32–0.47). Studies with controls deviated from Hardy-Weinberg equilibrium showed an evident association in dominant model (GA/AA vs GG: OR, 1.73 [95% CI, 1.04–2.89]). On the other hand, with respect to −592C/A polymorphism, significantly elevated cervical cancer risk was found in the overall analysis (A vs C: OR, 1.16 [95% CI, 1.04–1.31]; AA vs CC: OR, 1.36 [95% CI, 1.00–1.84]; CA/AA vs CC: OR, 1.18 [95% CI, 1.01–1.39]; AA vs CC/CA: OR, 1.25 [95% CI, 1.01–1.55]). Stratified analysis indicated that significantly increased risks were also found among Asians in the allelic model (A vs C: OR, 1.23 [95% CI, 1.01–1.49]).ConclusionsInterleukin 10−1082 G/A polymorphism showed no effect on cervical cancer risk in the overall analysis. The genetic polymorphism in IL-10−592C/A is a risk factor for developing cervical cancer, especially for Asians.

Cytochrome P450 1A1 (CYP1A1) gene polymorphisms and cervical cancer risk: a meta-analysis

2012 ◽  
Vol 39 (6) ◽  
pp. 6647-6654 ◽  
Author(s):  
Theodoros N. Sergentanis ◽  
Konstantinos P. Economopoulos ◽  
Souzana Choussein ◽  
Nikos F. Vlahos
Keyword(s):  
Cervical Cancer ◽  
Cytochrome P450 ◽  
Cancer Risk ◽  
Gene Polymorphisms ◽  
Meta Analysis ◽  
Cytochrome P450 1A1 ◽  
Cervical Cancer Risk ◽  
Cyp1a1 Gene

scholarly journals Association Between the XRCC3 Thr241Met Polymorphism and Cervical Cancer Risk: a Meta-analysis

2013 ◽  
Vol 14 (11) ◽  
pp. 6703-6707 ◽  
Author(s):  
Ling-Yan Qin ◽  
Xu Chen ◽  
Ping Li ◽  
Zheng Yang ◽  
Wu-Ning Mo
Keyword(s):  
Cervical Cancer ◽  
Cancer Risk ◽  
Meta Analysis ◽  
Cervical Cancer Risk ◽  
Xrcc3 Thr241met

scholarly journals Association Between the IL-6 rs1800795 Polymorphism and the Risk of Cervical Cancer: A Meta-Analysis of 1210 Cases and 1525 Controls

2016 ◽  
Vol 16 (5) ◽  
pp. 662-667 ◽  
Author(s):  
Haiping Liu ◽  
Dan Lyu ◽  
Yan Zhang ◽  
Lianbing Sheng ◽  
Ning Tang
Keyword(s):  
Cervical Cancer ◽  
Cancer Risk ◽  
Interleukin 6 ◽  
Fixed Effects ◽  
Meta Analysis ◽  
Developed Countries ◽  
Nucleotide Polymorphisms ◽  
Fixed Effects Model ◽  
Cervical Cancer Risk ◽  
Knowledge Infrastructure

Cervical cancer is the second most common cancer and the third leading cause of cancer-related death among females in less developed countries. Studies have shown that the single-nucleotide polymorphisms of interleukin 6 might be associated with cervical cancer risk. A total of 710 articles from EMBASE, EBSCO, Web of science, PubMed, Springer link, and Chinese National Knowledge Infrastructure databases were reviewed in our study. A meta-analysis on the associations between interleukin 6 rs1800795 polymorphism and cervical cancer risk was carried out by comparison using 5 genetic models. In this systematic review, 5 studies were analyzed. The pooled population included 2735 participants (1210 cases and 1525 controls). The overall odds ratio (G vs C alleles) using fixed-effects model was 0.85 (95% confidence interval 0.75-0.97), P = .02. Our results show that the C genotype of interleukin 6 rs1800795 is associated with higher cervical cancer risk. Our results indicate that interleukin 6 rs1800795 polymorphism might be associated with susceptibility to cervical cancer.

Association between CD95L polymorphism and cervical cancer risk: evidence from a meta-analysis

Tumor Biology ◽  
2014 ◽  
Vol 35 (6) ◽  
pp. 5137-5142 ◽  
Author(s):  
Jing Zhu ◽  
Lei Lu ◽  
Xiang Cheng ◽  
Rongkai Xie ◽  
Zhengqiong Chen ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cancer Risk ◽  
Meta Analysis ◽  
Cervical Cancer Risk
Sign in / Sign up

Export Citation Format

Share Document