scholarly journals Promiximab-duocarmycin, a new CD56 antibody-drug conjugates, is highly efficacious in small cell lung cancer xenograft models

Oncotarget ◽  
2017 ◽  
Vol 9 (4) ◽  
pp. 5197-5207 ◽  
Author(s):  
Lin Yu ◽  
Ying Lu ◽  
Yuqin Yao ◽  
Yu Liu ◽  
Yuxi Wang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung ◽  
Antibody Drug Conjugates ◽  
Drug Conjugates ◽  
Xenograft Models ◽  
Antibody Drug

scholarly journals Tyrosine Kinase Inhibitors, Antibody-Drug Conjugates, and Proteolysis-Targeting Chimeras: The Pharmacology of Cutting-Edge Lung Cancer Therapies

2021 ◽  
pp. e286-e293
Author(s):  
Jennifer W. Carlisle ◽  
R. Donald Harvey
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Kinase Inhibitor ◽  
Small Cell ◽  
Small Cell Lung ◽  
New Agents ◽  
Antibody Drug Conjugates ◽  
Drug Conjugates ◽  
Antibody Drug

The number of therapeutic options available for patients with advanced non–small-cell lung cancer has been led by deeper understanding of molecular drivers, immune function, and fundamental biology. In this article, we describe the relevant clinical pharmacologic characteristics of three broad classes of existing and investigational treatments, with a focus on mechanisms of action, adverse event profiles, pharmacokinetic and pharmacodynamic properties, and known and predicted resistance pathways. Specifically, within the kinase inhibitor class, agents directed against the RET, MET, and KRAS pathways are reviewed. Additionally, the first antibody-drug conjugates that target HER2 and HER3 are in trials and will ideally be available for patients soon. Finally, proteolysis-targeting chimeras approach pathway inhibition through enzyme degradation rather than target inhibition and are a promising platform for new agents in non–small-cell lung cancer and across cancer types. Each of these classes requires knowledge of clinical pharmacologic principles in development and use to ensure patient care in clinics and trials is optimized and personalized, including dosing and scheduling strategies, potential drug interactions, use in special populations, and monitoring parameters. Ideally, oncologists will continue to have new agents available across the non–small-cell lung cancer treatment spectrum to offer to a patient group that, until relatively recently, had few options.

scholarly journals Evaluating 225Ac and 177Lu Radioimmunoconjugates against Antibody–Drug Conjugates for Small-Cell Lung Cancer

2020 ◽  
Vol 17 (11) ◽  
pp. 4270-4279
Author(s):  
Andrew L. Lakes ◽  
Dahlia D. An ◽  
Stacey S. Gauny ◽  
Camille Ansoborlo ◽  
Benjamin H. Liang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung ◽  
Antibody Drug Conjugates ◽  
Drug Conjugates ◽  
Antibody Drug

scholarly journals NRXN1 as a novel potential target of antibody-drug conjugates for small cell lung cancer

Oncotarget ◽  
2020 ◽  
Vol 11 (39) ◽  
pp. 3590-3600
Author(s):  
Takuma Yotsumoto ◽  
Keita Maemura ◽  
Kousuke Watanabe ◽  
Yosuke Amano ◽  
Yoko Matsumoto ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung ◽  
Antibody Drug Conjugates ◽  
Potential Target ◽  
Drug Conjugates ◽  
Antibody Drug

scholarly journals Lorvotuzumab mertansine, a CD56-targeting antibody-drug conjugate with potent antitumor activity against small cell lung cancer in human xenograft models

mAbs ◽  
2014 ◽  
Vol 6 (2) ◽  
pp. 556-566 ◽  
Author(s):  
Kathleen R Whiteman ◽  
Holly A Johnson ◽  
Michele F Mayo ◽  
Charlene A Audette ◽  
Christina N Carrigan ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Antitumor Activity ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung ◽  
Antibody Drug Conjugate ◽  
Xenograft Models ◽  
Antibody Drug ◽  
Human Xenograft Models

Abstract 914: Activity of SGN-B6A in patient-derived xenograft models of non-small cell lung cancer

2021 ◽  
Author(s):  
Robert P. Lyon ◽  
John J. Gosink ◽  
Christopher J. Hale ◽  
Jackie L. Stilwell ◽  
Sean Allred ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung ◽  
Patient Derived Xenograft ◽  
Xenograft Models
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