scholarly journals Phthalate exposure promotes chemotherapeutic drug resistance in colon cancer cells

Oncotarget ◽  
2017 ◽  
Vol 9 (17) ◽  
pp. 13167-13180 ◽  
Author(s):  
Hsin-Pao Chen ◽  
Yung-Kuo Lee ◽  
Shih Yin Huang ◽  
Pei-Chun Shi ◽  
Ping-Chi Hsu ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Drug Resistance ◽  
Cancer Cells ◽  
Chemotherapeutic Drug ◽  
Colon Cancer Cells ◽  
Phthalate Exposure

scholarly journals Cancer upregulated gene 2, a novel oncogene, enhances migration and drug resistance of colon cancer cells via STAT1 activation

2013 ◽  
Vol 43 (4) ◽  
pp. 1111-1116 ◽  
Author(s):  
WARAPORN MALILAS ◽  
SANG SEOK KOH ◽  
SEOKHO KIM ◽  
RATAKORN SRISUTTEE ◽  
IL-RAE CHO ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Drug Resistance ◽  
Cancer Cells ◽  
Colon Cancer Cells

scholarly journals Transforming Growth Factor β Mediates Drug Resistance by Regulating the Expression of Pyruvate Dehydrogenase Kinase 4 in Colorectal Cancer

2016 ◽  
Vol 291 (33) ◽  
pp. 17405-17416 ◽  
Author(s):  
Yang Zhang ◽  
Yi Zhang ◽  
Liying Geng ◽  
Haowei Yi ◽  
Wei Huo ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Colon Cancer ◽  
Drug Resistance ◽  
Cancer Cells ◽  
Pyruvate Dehydrogenase ◽  
Pyruvate Dehydrogenase Kinase ◽  
Dependent Manner ◽  
Colon Cancer Cells ◽  
Pyruvate Dehydrogenase Kinase 4 ◽  
Mouse Xenograft Model

Drug resistance is one of the main causes of colon cancer recurrence. However, our understanding of the underlying mechanisms and availability of therapeutic options remains limited. Here we show that expression of pyruvate dehydrogenase kinase 4 (PDK4) is positively correlated with drug resistance of colon cancer cells and induced by 5-fluorouracil (5-FU) treatment in drug-resistant but not drug-sensitive cells. Knockdown of PDK4 expression sensitizes colon cancer cells to 5-FU or oxaliplatin-induced apoptosis in vitro and increases the effectiveness of 5-FU in the inhibition of tumor growth in a mouse xenograft model in vivo. In addition, we demonstrate for the first time that TGFβ mediates drug resistance by regulating PDK4 expression and that 5-FU induces PDK4 expression in a TGFβ signaling-dependent manner. Mechanistically, knockdown or inhibition of PDK4 significantly increases the inhibitory effect of 5-FU on expression of the anti-apoptotic factors Bcl-2 and survivin. Importantly, studies of patient samples indicate that expression of PDK4 and phosphorylation of Smad2, an indicator of TGFβ pathway activation, show a strong correlation and that both positively associate with chemoresistance in colorectal cancer. These findings indicate that the TGFβ/PDK4 signaling axis plays an important role in the response of colorectal cancer to chemotherapy. A major implication of our studies is that inhibition of PDK4 may have considerable therapeutic potential to overcome drug resistance in colorectal cancer patients, which warrants the development of PDK4-specific inhibitors.

Impedance-based drug-resistance characterization of colon cancer cells through real-time cell culture monitoring

Talanta ◽  
2021 ◽  
Vol 222 ◽  
pp. 121441
Author(s):  
Fuentes-Vélez Susana ◽  
Fagoonee Sharmila ◽  
Sanginario Alessandro ◽  
Gallo Valentina ◽  
Riganti Chiara ◽  
...  
Keyword(s):  
Cell Culture ◽  
Colon Cancer ◽  
Drug Resistance ◽  
Cancer Cells ◽  
Real Time ◽  
Colon Cancer Cells ◽  
Culture Monitoring

miRNA-29a reverses P-glycoprotein-mediated drug resistance and inhibits proliferation via up-regulation of PTEN in colon cancer cells

2020 ◽  
Vol 880 ◽  
pp. 173138 ◽  
Author(s):  
Xiaoxin Shi ◽  
Amir Valizadeh ◽  
Seyed Mostafa Mir ◽  
Zatollah Asemi ◽  
Ansar Karimian ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Drug Resistance ◽  
Cancer Cells ◽  
Colon Cancer Cells ◽  
P Glycoprotein

scholarly journals GLUT5 regulation by AKT1/3-miR-125b-5p downregulation induces migratory activity and drug resistance in TLR-modified colorectal cancer cells

2020 ◽  
Vol 41 (10) ◽  
pp. 1329-1340 ◽  
Author(s):  
Ga-Bin Park ◽  
Jee-Yeong Jeong ◽  
Daejin Kim
Keyword(s):  
Colon Cancer ◽  
Drug Resistance ◽  
Cancer Cells ◽  
Cell Metabolism ◽  
Enzyme Activation ◽  
Migration And Invasion ◽  
Drug Resistant ◽  
Cancer Resistance ◽  
Colon Cancer Cells ◽  
Migratory Activity

Abstract In cancer, resistance to chemotherapy is one of the main reasons for therapeutic failure. Cells that survive after treatment with anticancer drugs undergo various changes, including in cell metabolism. In this study, we investigated the effects of AKT-mediated miR-125b-5p alteration on metabolic changes and examined how these molecules enhance migration and induce drug resistance in colon cancer cells. AKT1 and AKT3 activation in drug-resistant colon cancer cells caused aberrant downregulation of miR-125b-5p, leading to GLUT5 expression. Targeted inhibition of AKT1 and AKT3 restored miR-125b-5p expression and prevented glycolysis- and lipogenesis-related enzyme activation. In addition, restoring the level of miR-125b-5p by transfection with the mimic sequence not only significantly blocked the production of lactate and intracellular fatty acids but also suppressed the migration and invasion of chemoresistant colon cancer cells. GLUT5 silencing with small interfering RNA attenuated mesenchymal marker expression and migratory activity in drug-resistant colon cancer cells. Additionally, treatment with 2,5-anhydro-d-mannitol resensitized chemoresistant cancer cells to oxaliplatin and 5-fluorouracil. In conclusion, our findings suggest that changes in miR-125b-5p and GLUT5 expression after chemotherapy can serve as a new marker to indicate metabolic change-induced migration and drug resistance development.

Role of AXL in invasion and drug resistance of breast and colon cancer cells

2016 ◽  
Vol 61 ◽  
pp. S79
Author(s):  
W.M. Abdel-Rahman ◽  
N.A. Al-khayyal ◽  
V.A. Nair ◽  
M.S. Ayad
Keyword(s):  
Colon Cancer ◽  
Drug Resistance ◽  
Cancer Cells ◽  
Colon Cancer Cells

scholarly journals A Switch from Canonical to Noncanonical Wnt Signaling Mediates Drug Resistance in Colon Cancer Cells

PLoS ONE ◽  
2011 ◽  
Vol 6 (11) ◽  
pp. e27308 ◽  
Author(s):  
Michael Bordonaro ◽  
Shruti Tewari ◽  
Catherine E. Cicco ◽  
Wafa Atamna ◽  
Darina L. Lazarova
Keyword(s):  
Colon Cancer ◽  
Drug Resistance ◽  
Wnt Signaling ◽  
Cancer Cells ◽  
Colon Cancer Cells

Livin gene plays a role in drug resistance of colon cancer cells

2010 ◽  
Vol 43 (7-8) ◽  
pp. 655-660 ◽  
Author(s):  
Xudong Wang ◽  
Jian Xu ◽  
Shaoqing Ju ◽  
Hongbing Ni ◽  
Jianhua Zhu ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Drug Resistance ◽  
Cancer Cells ◽  
Colon Cancer Cells

MicroRNA-137 chemosensitizes colon cancer cells to the chemotherapeutic drug oxaliplatin (OXA) by targeting YBX1

2017 ◽  
Vol 18 (1) ◽  
pp. 1-9 ◽  
Author(s):  
Yunsheng Guo ◽  
Yan Pang ◽  
Xia Gao ◽  
Min Zhao ◽  
Xin Zhang ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Chemotherapeutic Drug ◽  
Colon Cancer Cells
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