scholarly journals Dysregulation of YAP by the Hippo pathway is involved in intervertebral disc degeneration, cell contact inhibition, and cell senescence

Oncotarget ◽  
2017 ◽  
Vol 9 (2) ◽  
pp. 2175-2192 ◽  
Author(s):  
Cong Zhang ◽  
Feng Wang ◽  
Zhiyang Xie ◽  
Lu Chen ◽  
Arjun Sinkemani ◽  
...  
Keyword(s):  
Intervertebral Disc ◽  
Disc Degeneration ◽  
Intervertebral Disc Degeneration ◽  
Hippo Pathway ◽  
Cell Senescence ◽  
Contact Inhibition ◽  
Cell Contact ◽  
The Hippo Pathway

The hippo pathway orchestrates cytoskeletal organisation during intervertebral disc degeneration

2021 ◽  
Vol 123 (6) ◽  
pp. 151770
Author(s):  
Cong Zhang ◽  
Feng Wang ◽  
Zhiyang Xie ◽  
Lu Chen ◽  
Xiaotao Wu
Keyword(s):  
Intervertebral Disc ◽  
Disc Degeneration ◽  
Intervertebral Disc Degeneration ◽  
Hippo Pathway ◽  
The Hippo Pathway

scholarly journals Upregulated lnc‑HRK‑2:1 prompts nucleus pulposus cell senescence in intervertebral disc degeneration

2020 ◽  
Vol 22 (6) ◽  
pp. 5251-5261
Author(s):  
Dongbo Liang ◽  
Dinggang Hong ◽  
Fuyu Tang ◽  
Yuan Wang ◽  
Jianfeng Li ◽  
...  
Keyword(s):  
Intervertebral Disc ◽  
Nucleus Pulposus ◽  
Disc Degeneration ◽  
Intervertebral Disc Degeneration ◽  
Nucleus Pulposus Cell ◽  
Cell Senescence

scholarly journals Cell Senescence: A Nonnegligible Cell State under Survival Stress in Pathology of Intervertebral Disc Degeneration

2020 ◽  
Vol 2020 ◽  
pp. 1-12
Author(s):  
Yuang Zhang ◽  
Biao Yang ◽  
Jingkai Wang ◽  
Feng Cheng ◽  
Kesi Shi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cell Death ◽  
Intervertebral Disc ◽  
Disc Degeneration ◽  
Intervertebral Disc Degeneration ◽  
Cellular Level ◽  
Cell Senescence ◽  
Extrinsic Factors ◽  
Cell State ◽  
Potential Risk Factors

The intervertebral disc degeneration (IDD) with increasing aging mainly manifests as low back pain (LBP) accompanied with a loss of physical ability. These pathological processes can be preliminarily interpreted as a series of changes at cellular level. In addition to cell death, disc cells enter into the stagnation with dysfunction and deteriorate tissue microenvironment in degenerative discs, which is recognized as cell senescence. During aging, many intrinsic and extrinsic factors have been proved to have strong connections with these cellular senescence phenomena. Growing evidences of these connections require us to gather up critical cues from potential risk factors to pathogenesis and relative interventions for retarding cell senescence and attenuating degenerative changes. In this paper, we try to clarify another important cell state apart from cell death in IDD and discuss senescence-associated changes in cells and extracellular microenvironment. Then, we emphasize the role of oxidative stress and epigenomic perturbations in linking risk factors to cell senescence in the onset of IDD. Further, we summarize the current interventions targeting senescent cells that may exert the benefits of antidegeneration in IDD.

scholarly journals Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control

2007 ◽  
Vol 21 (21) ◽  
pp. 2747-2761 ◽  
Author(s):  
B. Zhao ◽  
X. Wei ◽  
W. Li ◽  
R. S. Udan ◽  
Q. Yang ◽  
...  
Keyword(s):  
Hippo Pathway ◽  
Growth Control ◽  
Tissue Growth ◽  
Contact Inhibition ◽  
Cell Contact ◽  
The Hippo Pathway

scholarly journals Disc cell senescence in intervertebral disc degeneration: Causes and molecular pathways

Cell Cycle ◽  
2016 ◽  
Vol 15 (13) ◽  
pp. 1674-1684 ◽  
Author(s):  
Chencheng Feng ◽  
Huan Liu ◽  
Minghui Yang ◽  
Yang Zhang ◽  
Bo Huang ◽  
...  
Keyword(s):  
Intervertebral Disc ◽  
Disc Degeneration ◽  
Intervertebral Disc Degeneration ◽  
Cell Senescence ◽  
Disc Cell ◽  
Molecular Pathways
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