scholarly journals Assessment of the effect of sphingosine kinase inhibitors on apoptosis,unfolded protein response and autophagy of T-cell acute lymphoblastic leukemia cells; indications for novel therapeutics

Oncotarget ◽  
2014 ◽  
Vol 5 (17) ◽  
pp. 7886-7901 ◽  
Author(s):  
Cecilia Evangelisti ◽  
Camilla Evangelisti ◽  
Gabriella Teti ◽  
Francesca Chiarini ◽  
Mirella Falconi ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
T Cell ◽  
Unfolded Protein Response ◽  
Kinase Inhibitors ◽  
Lymphoblastic Leukemia ◽  
Sphingosine Kinase ◽  
Leukemia Cells ◽  
Unfolded Protein ◽  
Cell Acute Lymphoblastic Leukemia ◽  
Protein Response

scholarly journals Notch3 contributes to T-cell leukemia growth via regulation of the unfolded protein response

Oncogenesis ◽  
2020 ◽  
Vol 9 (10) ◽  
Author(s):  
Maria Valeria Giuli ◽  
Giulia Diluvio ◽  
Eugenia Giuliani ◽  
Giulia Franciosa ◽  
Laura Di Magno ◽  
...  
Keyword(s):  
T Cell ◽  
Er Stress ◽  
Unfolded Protein Response ◽  
Lymphoblastic Leukemia ◽  
Acute Leukemias ◽  
Unfolded Protein ◽  
Cell Acute Lymphoblastic Leukemia ◽  
The Unfolded Protein Response ◽  
Protein Response

Abstract Unfolded protein response (UPR) is a conserved adaptive response that tries to restore protein homeostasis after endoplasmic reticulum (ER) stress. Recent studies highlighted the role of UPR in acute leukemias and UPR targeting has been suggested as a therapeutic approach. Aberrant Notch signaling is a common feature of T-cell acute lymphoblastic leukemia (T-ALL), as downregulation of Notch activity negatively affects T-ALL cell survival, leading to the employment of Notch inhibitors in T-ALL therapy. Here we demonstrate that Notch3 is able to sustain UPR in T-ALL cells, as Notch3 silencing favored a Bip-dependent IRE1α inactivation under ER stress conditions, leading to increased apoptosis via upregulation of the ER stress cell death mediator CHOP. By using Juglone, a naturally occurring naphthoquinone acting as an anticancer agent, to decrease Notch3 expression and induce ER stress, we observed an increased ER stress-associated apoptosis. Altogether our results suggest that Notch3 inhibition may prevent leukemia cells from engaging a functional UPR needed to compensate the Juglone-mediated ER proteotoxic stress. Notably, in vivo administration of Juglone to human T-ALL xenotransplant models significantly reduced tumor growth, finally fostering the exploitation of Juglone-dependent Notch3 inhibition to perturb the ER stress/UPR signaling in Notch3-dependent T-ALL subsets.

scholarly journals CD 47 agonist peptide PKHB 1 induces immunogenic cell death in T‐cell acute lymphoblastic leukemia cells

2018 ◽  
Vol 110 (1) ◽  
pp. 256-268 ◽  
Author(s):  
Ashanti Concepción Uscanga‐Palomeque ◽  
Kenny Misael Calvillo‐Rodríguez ◽  
Luis Gómez‐Morales ◽  
Eva Lardé ◽  
Thomas Denèfle ◽  
...  
Keyword(s):  
Cell Death ◽  
Acute Lymphoblastic Leukemia ◽  
T Cell ◽  
Lymphoblastic Leukemia ◽  
Leukemia Cells ◽  
Immunogenic Cell Death ◽  
Agonist Peptide ◽  
Cell Acute Lymphoblastic Leukemia

scholarly journals PS924 A DRUG SCREEN TO STUDY THE EFFECT OF EPIGENETIC INHIBITORS ON T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA CELLS

HemaSphere ◽  
2019 ◽  
Vol 3 (S1) ◽  
pp. 416
Author(s):  
C. Prieto ◽  
M. Broux ◽  
S. Demeyer ◽  
L. Albertí-Servera ◽  
K. Jacobs ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
T Cell ◽  
Lymphoblastic Leukemia ◽  
Leukemia Cells ◽  
Drug Screen ◽  
Cell Acute Lymphoblastic Leukemia

Targeted delivery of vincristine to T-cell acute lymphoblastic leukemia cells using an aptamer-modified albumin conjugate

RSC Advances ◽  
2016 ◽  
Vol 6 (52) ◽  
pp. 46366-46371 ◽  
Author(s):  
Seyed Mohammad Taghdisi ◽  
Noor Mohammad Danesh ◽  
Mohammad Ramezani ◽  
Khalil Abnous
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
T Cell ◽  
Clinical Application ◽  
Targeted Delivery ◽  
Lymphoblastic Leukemia ◽  
Leukemia Cells ◽  
Poor Solubility ◽  
Cell Acute Lymphoblastic Leukemia

Clinical application of vincristine in treatment of cancer is restricted because of its poor solubility and neuropathy.

scholarly journals TAL1/SCL is downregulated upon histone deacetylase inhibition in T-cell acute lymphoblastic leukemia cells

Leukemia ◽  
2011 ◽  
Vol 25 (10) ◽  
pp. 1578-1586 ◽  
Author(s):  
B A Cardoso ◽  
S F de Almeida ◽  
A B A Laranjeira ◽  
M Carmo-Fonseca ◽  
J A Yunes ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
T Cell ◽  
Histone Deacetylase ◽  
Lymphoblastic Leukemia ◽  
Leukemia Cells ◽  
Histone Deacetylase Inhibition ◽  
Cell Acute Lymphoblastic Leukemia
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