scholarly journals Interleukin gene polymorphisms in Chinese Han population with breast cancer, a case-control study

Oncotarget ◽  
2017 ◽  
Vol 9 (26) ◽  
pp. 17994-18001 ◽  
Author(s):  
Xiaoxiao Zuo ◽  
Miao Li ◽  
Ya Yang ◽  
Tiansong Liang ◽  
Hongyao Yang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gene Polymorphisms ◽  
Case Control Study ◽  
Case Control ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population ◽  
Control Study

Association of ADAMTS5 gene polymorphisms with osteoarthritis in Chinese Han population: a community-based case–control study

2012 ◽  
Vol 33 (11) ◽  
pp. 2893-2897 ◽  
Author(s):  
Jiaao Gu ◽  
Jiesheng Rong ◽  
Fulin Guan ◽  
Liying Jiang ◽  
Ting Zhang ◽  
...  
Keyword(s):  
Gene Polymorphisms ◽  
Case Control Study ◽  
Case Control ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Community Based ◽  
Han Population ◽  
Control Study

scholarly journals Associations between Interleukin Gene Polymorphisms and Risks of Developing Extremity Posttraumatic Osteomyelitis in Chinese Han Population

2020 ◽  
Vol 2020 ◽  
pp. 1-9 ◽  
Author(s):  
Nan Jiang ◽  
Su-yi Li ◽  
Yun-fei Ma ◽  
Yan-jun Hu ◽  
Qing-rong Lin ◽  
...  
Keyword(s):  
Gene Polymorphisms ◽  
Case Control Study ◽  
Case Control ◽  
Chinese Han Population ◽  
Healthy Controls ◽  
Chinese Han ◽  
Han Population ◽  
Posttraumatic Osteomyelitis ◽  
Genotyping Method ◽  
Control Study

This case-control study aimed to investigate potential associations between interleukin (IL) gene polymorphisms and the risks of developing extremity posttraumatic osteomyelitis (PTOM) in Chinese Han population. Altogether, 189 PTOM patients and 200 healthy controls were genotyped of IL-1α (rs17561, rs1800587), IL-1β (rs16944, rs1143627, rs1143634, rs2853550), IL-1RN (rs4251961, rs419598, rs315951), IL-4 (rs2243248, rs2243250), IL-6 (rs1800795, rs1800796, rs1800797), IL-8 (rs4073, rs2227306, rs2227307), IL-10 (rs3024491, rs3024496, rs1800871, rs1800872, rs1800896), IL-17A (rs2275913), and IL-17F (rs763780) using the SNaPshot genotyping method. Statistical differences were observed regarding the genotype distributions of rs16944 (P=0.049) and rs4251961 (P=0.007) between the patients and healthy controls. In addition, significant associations were found between rs16944 and the risk of PTOM development by dominant (OR=1.854, P=0.017), homozygous (OR=1.831, P=0.041), and heterozygous (OR=1.869, P=0.022) models, and of rs1143627 by dominant (OR=1.735, P=0.032) and homozygous (OR=1.839, P=0.040) models. Moreover, significant links were also identified between rs4251961 and the susceptibility to PTOM by dominant (OR=0.446, P=0.005) and heterozygous (OR=0.409, P=0.003) models, and of rs1800796 by dominant (OR=4.184, P=0.029), homozygous (OR=4.378, P=0.026), and heterozygous (OR=3.834, P=0.046) models. The present outcomes demonstrated that rs16944, rs1143627, and rs1800796 associate with increased risks, while rs4251961 links to a decreased risk of PTOM development in Chinese Han population.

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