scholarly journals Genome-wide identification of long non-coding RNA and mRNA profiling using RNA sequencing in subjects with sensitive skin

Oncotarget ◽  
2017 ◽  
Vol 8 (70) ◽  
pp. 114894-114910 ◽  
Author(s):  
Li Yang ◽  
Lechun Lyu ◽  
Wenjuan Wu ◽  
Dongyun Lei ◽  
Ying Tu ◽  
...  
Keyword(s):  
Rna Sequencing ◽  
Sensitive Skin ◽  
Mrna Profiling ◽  
Non Coding Rna ◽  
Genome Wide ◽  
Long Non Coding Rna

scholarly journals Analyses of Long Non-Coding RNA and mRNA profiling using RNA sequencing during the pre-implantation phases in pig endometrium

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Yueying Wang ◽  
Songyi Xue ◽  
Xiaoran Liu ◽  
Huan Liu ◽  
Tao Hu ◽  
...  
Keyword(s):  
Rna Sequencing ◽  
Mrna Profiling ◽  
Non Coding Rna ◽  
Long Non Coding Rna

scholarly journals Pharmacogenomics of Lithium Response in Bipolar Disorder

2021 ◽  
Vol 14 (4) ◽  
pp. 287
Author(s):  
Courtney M. Vecera ◽  
Gabriel R. Fries ◽  
Lokesh R. Shahani ◽  
Jair C. Soares ◽  
Rodrigo Machado-Vieira
Keyword(s):  
Bipolar Disorder ◽  
Association Studies ◽  
Mood Stabilizer ◽  
Genome Wide Association Studies ◽  
Nucleotide Polymorphisms ◽  
Non Coding Rna ◽  
Genome Wide ◽  
Lithium Response ◽  
Genetic Loading ◽  
Long Non Coding Rna

Despite being the most widely studied mood stabilizer, researchers have not confirmed a mechanism for lithium’s therapeutic efficacy in Bipolar Disorder (BD). Pharmacogenomic applications may be clinically useful in the future for identifying lithium-responsive patients and facilitating personalized treatment. Six genome-wide association studies (GWAS) reviewed here present evidence of genetic variations related to lithium responsivity and side effect expression. Variants were found on genes regulating the glutamate system, including GAD-like gene 1 (GADL1) and GRIA2 gene, a mutually-regulated target of lithium. In addition, single nucleotide polymorphisms (SNPs) discovered on SESTD1 may account for lithium’s exceptional ability to permeate cell membranes and mediate autoimmune and renal effects. Studies also corroborated the importance of epigenetics and stress regulation on lithium response, finding variants on long, non-coding RNA genes and associations between response and genetic loading for psychiatric comorbidities. Overall, the precision medicine model of stratifying patients based on phenotype seems to derive genotypic support of a separate clinical subtype of lithium-responsive BD. Results have yet to be expounded upon and should therefore be interpreted with caution.

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